ABSTRACT:
M. tinctoria plant has many therapeutic uses in traditional Indian medicine. M. tinctoria has Antibacterial, Antifungal, Hepatoprotective, Antioxidant, Wound Healing, Dye Yielding and Larvicidal properties. The study is employ to the anti- ulcerogenic potential of M. tinctoria extract. The plant extraction was done with 50% ethanol and 50% water (hydro-alcoholic). OECD guidelines were used for acute- toxicity (14 days) and Sub-acute toxicity (28 days). The study was carried by ligation (pylorus) and drug-induced ulcer models in Wistar rats. The anti-ulcer activity of M. tinctoria was compared with the standard drugs to perceive the anti-ulcerogenic potential. The Pharmacognostic analysis was performed according to the Indian pharmacopoeia. A preliminary Phytochemical test of the aerial part of M.tinctoria was performed which showed the presence of carbohydrates, amino acid, glycosides, flavonoids, alkaloids in the hydro-alcoholic extract. Acute-oral toxicity (14 days) and Sub-acute oral toxicity (28 days) were performed and doesn’t show any effect on body weight as well as organ weight and was non-toxic. M. tinctoria extract (MTE) effectively prevents the gastric mucosa from the threat of ulcers caused by pylorus ligation and aspirin-induced ulcers. MTE demonstrated a substantial reduction in the ulcer index developed by all 2 experimental models comparable to the standard drug Omeprazole. Current evidence shows that aerial parts of MTE have substantial antiulcer action.