Author(s):
Kunal Bhattacharya, Atanu Bhattacharjee, Nongmaithem Randhoni Chanu, Biplab Kumar Dey, Chanam Melody Devi
Email(s):
kunal22101994@gmail.com
DOI:
10.5958/0974-360X.2021.00114.1 
Address:
Kunal Bhattacharya1,3*, Atanu Bhattacharjee2,3, Nongmaithem Randhoni Chanu3, Biplab Kumar Dey3, Chanam Melody Devi1,3
1NETES Institute of Pharmaceutical Science, Mirza, Kamrup, Assam-781125.
2Royal School of Pharmacy, Royal Global University, Guwahati, Assam-781035.
3Faculty of Pharmaceutical Science, Assam down Town University, Guwahati, Assam – 781026.
*Corresponding Author
Published In:
Volume - 14,
Issue - 2,
Year - 2021
ABSTRACT:
Helminthiasis, also known as worm infection is macro parasitic disease of humans and other animals in which a part of the body is infected with parasitic worms, known as Helminths. There has been an enormous interest in the development of alternative medicines against Helminthiasis, specifically screening for phytochemicals with Antihelminthic activity. The present study aims to provide Phytochemical screening and antihelminthic activity results of leaves extract of Artocarpus altilis using dichloromethane-methanol as extraction solvent. So far no work has been carried out using combinations of solvents for leaves of Artocarpus altilis for carrying out anthelmintic activity. In-vitro anthelmintic activity carried out against Indian adult earthworm Pheretima posthuma using dichloromethane: methanol leaves extract of Artocarpus altilis showed promising activity when compared to standard albendazole.
Cite this article:
Kunal Bhattacharya, Atanu Bhattacharjee, Nongmaithem Randhoni Chanu, Biplab Kumar Dey, Chanam Melody Devi. Phytochemical screening and Anthelmintic activity of Artocarpus altilis extract. Research J. Pharm. and Tech. 2021; 14(2):640-644. doi: 10.5958/0974-360X.2021.00114.1
Cite(Electronic):
Kunal Bhattacharya, Atanu Bhattacharjee, Nongmaithem Randhoni Chanu, Biplab Kumar Dey, Chanam Melody Devi. Phytochemical screening and Anthelmintic activity of Artocarpus altilis extract. Research J. Pharm. and Tech. 2021; 14(2):640-644. doi: 10.5958/0974-360X.2021.00114.1 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-2-10
REFERENCES:
1. Ramila M, Manoharan A. Characteristics of pharmacognostical significance of Erythrina variegate var. and Ficusracemosa Linn. Bark. J Chem Pharm Res. 2011; 3(6): 707-14.
2. Muraleedharannair JM, Johnson MA, Mony M, Zachariah MP, Solomon J. Phytochemical studies on Azollapinnata R. Br., Marsileaminuta L. And Salviniamolesta Mitch. Asian Pac J Trop Biomed. 2011; 2: S26-29.
3. Shiddamallayya N, Azara Y, Gopakumar K. Hundred common forest medicinal plants of Karnataka in primary healthcare. Indian J TradKnowl. 2010; 9 (1): 90-95.
4. Carolyn Glatz.An Introduction to herbalism. Healthy Life journal 2011 .
5. https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=184181#null.
6. Jagtap. UB, Bapat VA. Artocarpus: A review of its traditional uses, phytochemistry and pharmacology. J Ethanopharmacol. 2010;12(9);143-44.
7. Somashekhar M, Naira Nayeem, Basavraj Sonnad. A Review on Family Moraceae (Mulberry) With a Focus on Artocarpus Species. WJPPS. 2013; 2(5): 2614-2621.
8. Pradhan C, Mohanty M, Rout A. Phytochemical screening and comparative bioefficacy assessment of Artocarpus altilis leaf extracts for antimicrobial activity. Front. Life Sc., 2013b; 6(3–4): 71–76.
9. Nguyen MT, Nyugen NT, Nyugen,dau HT, Nyugen HX, Dang PH, Le TM, Nyugen Phan TH et al. Dihydrochalcones from Artocarpusaltilis and their antiausteric activity. Planta Med. 2014; 1:1-104.
10. O. A. Adaramoye,O. O. Akanni .Protective effects of Artocarpusaltilis (Moraceae) on cadmium-induced changes in sperm characteristics and testicular oxidative damage in rats. Andrologia 2016;48(2):152-163.
11. Prashant T, Bimlesh K, Mandeep K, Gurpreet K, Harleen K. Phytochemical screening and extraction: A review. Int Pharm Sci. 2011; 1(1): 98-106.
12. Harbone JB. Phytochemical methods: a guide to modern techniques of plant analysis, 3rd edition Thompson Publishing IT. 1998: 5-21.
13. Nissanti Goindasami. et al. / Asian Journal of Research in Biological and Pharmaceutical Sciences. 6(1), 2018, 10-15.
14. Dadang Irfan Husori1, Sumardi, Heron Tarigan, Selviani Gemasih, Sri Rahayu Ningsih. In vitro Anthelmintic Activity of Acanthus ilicifolius Leaves Extracts on Ascaridia galli and Pheretima posthum. Journal of Applied Pharmaceutical Science. 2018, 8(02), 164-167.
15. Dipak N. Raut1, Subodh C. Pal, Subhash C. Mandal. Anthelmintic Potential of Dendrophthoe falcata Etting.(L.F.) Leaf. International Journal of Pharma Research and Development. 2009; 6, 0974 – 9446.
16. Das SS., Monalisha D, Ghosh AK. Determination of Anthelmintic Activity of the Leaf and Bark Extract of Tamarindus Indica Linn. Indian J Pharm Sci. 2011; 73(1): 104-107.
17. K. Himamalini, A. Rajani, Ratana Sundari, Anthelmentic Activity of Methanolic Leaf Extract of Sophora interupta. International Research Journal of Pharmacy. 2013; 4(8): 2230-8407.
18. Abdul Aziz, Golam Sarwar Raju, Abhijit Das, Jamiuddin Ahmed, Md. Mizanur Rahman Moghal. Evaluation of In vitro Anthelmintic Activity, Total Phenolic Content and Cytotoxic Activity of Crinum latifolium L. (Family: Amaryllidaceae). Advanced Pharmaceutical Bulletin, 2014, 4(1): 15-19.
19. Anuj Kumar Agrahari, Ashutosh Meher, Amiya Ranjan Padhan, Srimanta Dash. Assessment of anthelmintic activity of Jussiaea hyssopifolia G. Don. Asian Journal of Plant Science and Research, 2011; 1 (4):87-91
20. Neha Shekhawat and Rekha Vijayvergia. Anthelmintic Activity of Extracts of Some Medicinal Plants. International Journal of Computational Science and Mathematics. 2011; 3(2): 183-187
21. K. Gnaneswari, Y. Padma, R. R. Venkata Raju and K. N. Jayaveera. In vitro anthelmintic activity of Leonotis nepetiifolia (L.) R.Br., a potential medicinal plant. Journal of Chemical and Pharmaceutical Research. 2013; 5(2):345-348
22. S. T. V. Raghavamma And N. Rama Rao. In Vitro Evaluation of Anthelmintic Activity of Nauclea orientalis Leaves. Indian Journal of Pharmaceutical Sciences. 2010; 520-523
23. Aziz A, Sarwar Raju G, Das A, Ahmed J, Moghal MMR. Evalu¬ation of In vitro Anthelmintic Activity, Total Phenolic Content and Cytotox¬ic Activity of Crinum latifolium L. (Family: Amaryllidaceae). Adv Pharm Bull, 2014; 4(1):15-9.
24. Mute VM. Anthelmintic effect of Tamarind indica linn leaves juice exract on Pheretima posthuma. International Journal of Pharmaceutical and Research Development. 2009;7:1-6.
25. Sharma US, Sharma UK, Singh A, Sutar N, Singh PJ. In vitro an¬thelmintic activity of Murraya koenigii Linn. Leaves extracts. International Journal of Pharma and Bio Sciences, 2010; 1(3):1-4.
26. Roy H. Preliminary phytochemical investigation and anthel-mintic activity of Acanthospermumhispidum DC. Journal of Pharmaceuti¬cal Science and Technology, 2010; 2(5):217-21
27. Niezen JH, Waghorn GC, Charleston WA. Growth and gastrointestinal nematode parasitism in lambs grazing either Lucerne (Medicago sativa) or (Hedysarum coronarium), which contains condensed tannins. J Agri Sci. 1995;125:281–9.
28. Shrestha B, Basnett H, Babu VD, Patel SS. Anthelmintic and Antimicrobial activity of the chloroform extract of Pergularia Daemia Forsk Leaves. Adv Pharmacol Toxicol. 2009;10:13–6.
29. Athanasiadou S, Kyriazakis I, Jackson F, Coop RL. Direct anthelmintic effects of condensed tannins towards different gastrointestinal nematodes of sheep: in vitro and in vivo studies. Vet Parasitol. 2001;99:205–19.