Author(s): C. Jayakumar, V. Mansa Devi, D.M. Reddy Prasad, R. Sridar


DOI: 10.5958/0974-360X.2021.00138.4   

Address: C. Jayakumar1*, V. Mansa Devi1, D.M. Reddy Prasad2, R. Sridar3
1Department of Applied Science and Technology, A.C. Tech, Anna University, Chennai - 600025, India.
2Petroleum and Chemical Engineering Programme Area, Faculty of Engineering, Universiti Teknologi Brunei, BE1410 Darussalam, Brunei.
3Department of Chemical Engineering, Pondicherry Engineering College, Puducherry - 605014, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2021

In the present study, hydrotropic solubilization technique has been used to solubilize the poorly water soluble anti-diuretic drugs such as theophylline for its spectrophotometric analysis. Sodium salicylate and resorcinol solutions of strength 7.5 M and 5.5 M respectively, have been used as a hydrotropic agent. Compared to the solubility in distilled water, a twofold increase in the aqueous solubility of theophylline with respect to sodium salicylate (7.5 M) and 1.3 times enhancement in the solubility of theophylline with regard to resorcinol (5.5 M) have been observed. The interference of the hydrotropic agent in the analysis was found to be nil. Also, the hydrotrope is economical and free from pollution. The proposed method is new, simple, correct and reproducible. Statistical data proved the accuracy, reproducibility, and precision of the proposed method.

Cite this article:
C. Jayakumar, V. Mansa Devi, D.M. Reddy Prasad, R. Sridar. New Quantitative Technique for estimation of solubility of Theophylline using Hydrotropic Solubilizing Agents. Research J. Pharm. and Tech. 2021; 14(2):793-796. doi: 10.5958/0974-360X.2021.00138.4

C. Jayakumar, V. Mansa Devi, D.M. Reddy Prasad, R. Sridar. New Quantitative Technique for estimation of solubility of Theophylline using Hydrotropic Solubilizing Agents. Research J. Pharm. and Tech. 2021; 14(2):793-796. doi: 10.5958/0974-360X.2021.00138.4   Available on:

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