Author(s): Krishna Yadav, Deependra Singh, Manju Rawat Singh

Email(s): manjursu@gmail.com

DOI: 10.5958/0974-360X.2021.00172.4   

Address: Krishna Yadav, Deependra Singh, Manju Rawat Singh*
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, 492010, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2021


ABSTRACT:
Psoriasis is a highly complex autoimmune disease of skin with keratinocytes that differentiate abnormally. Because of the inaccessibility of the adequate delivery system, a very favored treatment approaches contemplating topical treatment with current delivery approach are unreliable in targeting disease symptoms. The current work involved the development and characterization of Triamcinolone acetonide loaded solid lipid nanoparticles (TAC-SLNs) and their invitro characterization. The findings revealed that SLNs would substantially increase TA drug permeation across the skin, limiting them to dermis epidermis and helping to achieve the full clinical value of medications. It was also able to sustain the release of drug from lipid carrier. The outcomes of this research concluded that SLNs may efficiently deliver corticosteroids for the efficient treatment of psoriasis.


Cite this article:
Krishna Yadav, Deependra Singh, Manju Rawat Singh. Development and Characterization of Corticosteroid loaded Lipid carrier system for Psoriasis. Research J. Pharm. and Tech. 2021; 14(2):966-970. doi: 10.5958/0974-360X.2021.00172.4

Cite(Electronic):
Krishna Yadav, Deependra Singh, Manju Rawat Singh. Development and Characterization of Corticosteroid loaded Lipid carrier system for Psoriasis. Research J. Pharm. and Tech. 2021; 14(2):966-970. doi: 10.5958/0974-360X.2021.00172.4   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-2-68


REFERENCES:
1.    Pradhan M, Singh D, Singh MR. Novel colloidal carriers for psoriasis: Current issues, mechanistic insight and novel delivery approaches. J Control Release. 2013;170(3):380-395. DOI: https://DOI.org/10.1016/J.jconrel.2013.05.020
2.    Yadav K, Singh D, Singh MR. Protein biomarker for psoriasis: A systematic review on their role in the path mechanism, diagnosis, potential targets and treatment of psoriasis. Int J Biol Micromole. 2018;118(Pt B):1796-1810. Doi: 10.1016/J.Ijbiomac.2018.07.021
3.    Pradhan M, Singh D, Singh MR. Development and evaluation of novel topical formulations containing psoralen for management of psoriasis. Planta Med. 2015;81(05): PP12. DOI:10.1055/s-0035-1545229
4.    Bochénska K, Smolińska E, Moskot M, Jakóbkiewicz-Banecka J, Gabig-Cimińska M. Models in the research process of psoriasis. Int J Mol Sci. 2017;18(12):1-17. DOI:10.3390/ijms18122514
5.    Sonawane R, Harde H, Katariya M, Agrawal S, Jain S. Solid lipid nanoparticles-loaded topical gel containing combination drugs: an approach to offset psoriasis. Expert Open Drug Deliv. 2014;11(12):1833-1847. doi:10.1517/17425247.2014.938634
6.    Jain A, Doppalapudi S, Dumb AJ, Khan W. Tacrolimus and curcumin co-loaded liposphere gel: Synergistic combination towards management of psoriasis. J Control Release. 2016; 243:132-145. DOI: 10.1016/J.Jconrel.2016.10.004
7.    Del Rosso JQ, cash K. Topical Corticosteroid Application and the Structural and Functional Integrity of the Epidermal Barrier. J Clin Aesthet Dermatol. 2013; 6(11):20-27.
8.    Nantel-Battista M, Richer V, Marcil I, Benohanian A. Treatment of nail psoriasis with intralesional triamcinolone acetonide using a needle-free jet injector: a prospective trial. J Cutan Med Surg. 2014;18(1):38-42. doi:10.2310/7750.2013.13078
9.    Issa MCA, Kassuga LEBP, Chevrand NS, Pires MTF. Topical delivery of triamcinolone via skin pretreated with ablative radiofrequency: a new method in hypertrophic scar treatment. Int J Dermatol. 2013; 52(3):367-370. doi:10.1111/J.1365-4632.2012. 05704.x
10.    Pradhan M, Singh D, Singh MR. Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders. Artif Cells, Nanomedicine Biotechnol. 2016;44(1):392-400. DOI:10.3109/21691401.2014.955105
11.    Pradhan M, Singh D, Singh MR. Fabrication, optimization and characterization of Triamcinolone acetonide loaded nanostructured lipid carriers for topical treatment of psoriasis: Application of Box Behnken design, in vitro and ex vivo studies. J Drug Devil Sci Technol. 2017; 41:325-333. DOI: https:// DOI.org/10.1016/j.jddst.2017.07.024
12.    Altamirano-Vallejo JC, Navarro-Partida J, Gonzalez-De la Rosa A, et al. Characterization and Pharmacokinetics of Triamcinolone Acetonide-Loaded Liposomes Topical Formulations for Vitreoretinal Drug Delivery. J Ocul Pharmacol Ther. 2018;34(5):416-425. DOI:10.1089/jop.2017.0099
13.    Shah, Muhammad Raza Imran M, Ullah S. Lipid-Based Nanocarriers for Drug Delivery and Diagnosis. Matthew Deans; 2017.
14.    Singh D, Pradhan M, Shrivastava S, Murthy SN, Singh MR. Chapter 11 - Skin autoimmune disorders: lipid biopolymers and colloidal delivery systems for topical delivery. In: Grumezescu AM, ed. Nanobiomaterials in Galenic Formulations and Cosmetics. William Andrew Publishing; 2016:257-296. DOI: https://DOI.org/10.1016/B978-0-323-42868-2.00011-5
15.    Yadav K, Chauhan NS, Saraf S, Singh D, Singh MR. Challenges and need of delivery carriers for bioactive and biological agents: an introduction. In: Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents. Elsevier; 2020:1-36. doi:10.1016/b978-0-12-819666-3.00001-8
16.    Singh MR, Pradhan K, Singh D. Lipid matrix systems with emphasis on lipid microspheres: potent carriers for transcutaneous delivery of Bioactive. Cur Drug Devil. 2012; 9(3):243-254.
17.    Nasr M, Mansour S, Mortada ND, El Shamy AA. Lipospheres as Carriers for Topical Delivery of Aceclofenac: Preparation, Characterization and in Vivo Evaluation. AAPS Pharm Sci Tech. 2008;9(1):154-162. DOI:10.1208/s12249-007-9028-2
18.    Salome Amarachi C, Attama A, Agubata CO, Ogbonna J, Onunkwo G. Recent advances in lipospheres drug delivery system. J Pharm Res. 2012; 5:1743-1748.
19.    Jain A, Pooladanda V, Bulbake U, et al. Liposphere mediated topical delivery of thymoquinone in the treatment of psoriasis. Nanomedicine. 2017; 13(7):2251-2262. doi:10.1016/ J.Nano. 2017.06.009
20.    Dudala TB, Yalavarthi PR, Vadlamudi HC, et al. A perspective overview on lipospheres as lipid carrier systems. Int J Pharm Investig. 2014;4(4):149-155. doi:10.4103/2230-973X.143112
21.    Khurana S, Bedi PMS, Jain NK. Preparation and evaluation of solid lipid nanoparticles based nanogel for dermal delivery of meloxicam. Chem Phys Lipids. 2013;175-176:65-72. doi:10.1016/ J. Chemphyslip.2013.07.010
22.    Gupta V, Trivedi P. Ex vivo localization and permeation of cisplatin from novel topical formulations through excised pig, goat, and mice skin and in vitro characterization for effective management of skin-cited malignancies. Artif cells, nanomedicine, Biotechnol. 2015;43(6):373-382. doi:10.3109/ 21691401.2014.893523
23.    Kelidari HR, Saeedi M, Akbari J, et al. Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles. Colloids Surfaces B Biointerfaces. 2015; 128:473-479. DOI: https://DOI.org/10.1016/J.Colsurfb.2015.02.046

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