Author(s): Vaibhav Changediya, Rupalben Jani, Pradip Kakde


DOI: 10.5958/0974-360X.2021.00179.7   

Address: Vaibhav Changediya*, Rupalben Jani, Pradip Kakde
Department of Pharmaceutics, Dr. Vedprakash Patil Pharmacy College, Aurangabad- 431002, Maharashtra, India.
Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara- 376104 Gujarat, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2021

The present work aimed to develop nanoemulsion of mefenamic acid for improving its efficacy, stability, and permeability for the treatment of rheumatoid arthritis. A nanoemulsion was prepared using aqueous titration method composed of capmul oil as the oil phase, tween 60 as surfactant and Polyethylene glycol 400 as cosurfactant and evaluated. The aqueous phase titration method was employed for constructing the existing zone of nanoemulsion in pseudoternary phase diagrams representing three axes of the aqueous phase, oil, and mixture of surfactant and cosurfactant. The prepared nanoemulsions were placed in tightly closed glass vials and stored at ambient temperature. These drug-loaded formulations were subjected to physical stability tests [centrifugation stress (5000 rpm, 30 min), heating cooling stress (0 and 45ºC, eight cycles) and freeze-thawing stress (-21 and 25 ºC, =48 h)], appearance, percent transmittance, refractive index, Electrical conductivity. In conclusion, nanoemulsion of mefenamic acid was developed to a satisfactory level in terms of physical stability tests, appearance, percent transmittance, refractive index, Electrical conductivity, lower surfactant concentration. The present study endorsed nanoemulsion of mefenamic acid to be a promising choice over conventional formulations for the treatment of rheumatoid arthritis.

Cite this article:
Vaibhav Changediya, Rupalben Jani, Pradip Kakde. Development and Evaluation of Mefenamic acid Nanoemulsion. Research J. Pharm. and Tech. 2021; 14(2):1003-1007. doi: 10.5958/0974-360X.2021.00179.7

Vaibhav Changediya, Rupalben Jani, Pradip Kakde. Development and Evaluation of Mefenamic acid Nanoemulsion. Research J. Pharm. and Tech. 2021; 14(2):1003-1007. doi: 10.5958/0974-360X.2021.00179.7   Available on:

1.    Oswal T, Naik S. Formulation and evaluation of mefenamic acid emulgel. IJPRD , 2014; 5(12): 91-100.
2.    Cesur S, Yaylaci C. Optimum kinetic parameters of mefenamic acid crystallization by PBM. JCPT,2012; 2: 81-95.
3.    Patel KC, Pramanik S. Formulation and characterization of mefenamic acid loaded polymeric nanoparticles. World J Pharm Sci, 2014; 3(6): 1391-1405.
4.    Sriamornsak P, Limmatvapirat S, Piriyaprasarth S, Mansukmanee P, Huang Z. A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution. Asian J Pharm Sci, 2015; 10: 121-127.
5.    Kamboj S, Saini V, Bala S, Sharma G. Formulation and characterization of drug loaded niosomal gel for anti-inflammatory activity. International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering, 2013; 7(2): 541-545.
6.    Kumar L, Verma R. In vitro evaluation of topical gel prepared using natural polymer. International Journal of Drug Delivery, 2010: 2: 58–63.
7.    Nirmala MJ, Mukherjee A, Chandrasekaran N. A nanoemulsion drug delivery system for an aqueous insoluble drug ultrasonication technique for ramipril preparation. Int J Chem Tech Res, 2014; 6(3): 2020-2022.
8.    Modi JD, Patel JK. Evaluate in vivo and in vitro model on naoemulsion based gel formulation of aceclofenac. IJPPR, 2011; 2(2): 230-234.
9.    Mishra RK, Soni GC, Mishra RP. Nanoemulsion: A review article. World J Pharm Sci, 2014; 3(9): 258-274.
10.    Amaravathi V, Kishore D, Firoz S, Mouli YC, Venkataramudu T. Formulation and evaluation of mefenamic acid tablets by using modified starch. AJPST, 2012; 2(2): 46-53.
11.    Bhagat KA, Bhura MRG, Shah SK. Formulation and evaluation of topical nanoemulgel of adapalene. World J Pharm Sci, 2015; 3(4): 1013-1024.
12.    Kota S, Khan AW, Ansari SH, Sharma RK, Ali J. Anti HIV nanoemulsion formulation: optimization and in vitro-in vivo evaluation. Int J Pharm, 2014; 462: 129-134.
13.    Dev A, Chodankar R, Shelke O. Emulgels: a novel topical drug delivery system. Pharmaceutical and Biological Evaluations, 2015; 2(4), pp. 64-75.
14.    Lala RR, Awari NG. Nanoemulsion based gel formulations of COX-2 inhibitors for enhanced efficacy in inflammatory conditions. Appl Nano sci, 2014; 4:143-151.
15.    Abd-Allah F, Dawaba HM, Mansour A, Ahmed AMS. Evaluation of the anti-inflammatory and analgesic effects of piroxicam-loaded microemulsion in topical formulation. Int J Pharm Pharm Sci, 2011; 3(2): 66-70.
16.    Rasheed A, Kumar ACK. Synthesis, hydrolysis and pharmacodynamic profiles of novel prodrugs of mefenamic acid. IJCPR, 2009; 1(1): 47-55.
17.    Thakur N, Garg G, Sharma PK, Kumar N. Nanoemulsions: A Review on Various Pharmaceutical Applications. GJP, 2012; 6(3): 222-225.
18.    Hussain A, Samad A, Singh SK, Haque MW, Faruk A, Ahmed FJ. Nanoemulsion gel – based topical delivery of antifungal drug: Invitro activity and in vivo. Drug Delivery, 2016; 23(2): 642-647.
19.    Psarras N, Rekka E, Kourounakis P. The involvement of Tolfenamic acid, Mefenamic acid and Nimesulide in free radical processes. Pharm Sci, 1995; 1: 483-486.
20.    Mangale MR, Pathak SS, Mene HR, More BA. Nanoemulsion: as pharmaceutical overview. Int J Pharm Sci Rev Res, 2015; 33(1): 244-252.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available