Brahamdutt, Sonia Narwal, Aditay Kumar, Manjusha Chaudhary, Vikas Budhwar
email@example.com , firstname.lastname@example.org , email@example.com , firstname.lastname@example.org , email@example.com
Brahamdutt1, Sonia Narwal2, Aditay Kumar1, Manjusha Chaudhary3, Vikas Budhwar1*
1Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak (Haryana), India - 124001.
2Faculty of Pharmaceutical Sciences, PDM University, Bahadurgarh.
3University Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, India -136119.
Volume - 14,
Issue - 4,
Year - 2021
Background: Eutectics are basically multi-component crystalline solids closely related to solid solutions. However, the structural organization of eutectics has not been studied in as much detail as solid solutions, which are defined based on the arrangement of a major (solvent) and a minor (solute) component in the crystal lattice. Purpose: The goal of this study is basically improvement in aqueous solubility of poorly water soluble drug i.e curcumin via its eutectic formation by using salicylic acid as coformer. Material and Method: Here the eutectic mixture of curcumin and salicylic acid was prepared by solvent evaporation technique for improving the dissolution behaviour of curcumin. DSC and FT-IR spectroscopy were used as analytical techniques for characterization of eutectic mixture. Result: The DSC and FT-IR spectroscopy conformed the formation of eutectic mixture and In-Vitro dissolution studies revealed an improved dissolution behaviour for eutectic mixture (69.38 %) as compared to the pure curcumin (40.53%). Conclusion: The study conclude that binary systems improved the dissolution behaviour of poorly water soluble drugs without changing the physiochemical and pharmacological properties of concerned API.
Cite this article:
Brahamdutt, Sonia Narwal, Aditay Kumar, Manjusha Chaudhary, Vikas Budhwar. Formulation of Eutectic mixture of Curcumin with Salicylic Acid for improving its Dissolution Profile. Research Journal of Pharmacy and Technology. 2021; 14(4):1875-9. doi: 10.52711/0974-360X.2021.00331
Brahamdutt, Sonia Narwal, Aditay Kumar, Manjusha Chaudhary, Vikas Budhwar. Formulation of Eutectic mixture of Curcumin with Salicylic Acid for improving its Dissolution Profile. Research Journal of Pharmacy and Technology. 2021; 14(4):1875-9. doi: 10.52711/0974-360X.2021.00331 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-4-7
1. Paun JS, Raval MK, Tank HM, Sheth NR. Optimization of Solvents and Processing Conditions for Crystallization of Aceclofenac. Asian Journal of Research Pharmaceutical Sciences. 2013; 3 (3): 122-132.
2. Cherukuvada S, Nangia A. Eutectics as improved pharmaceutical materials: design, properties and characterization, Chemical Communications. 2014; 50: 906-923.
3. Thipparaboinaa R, Thumurib D, Chavana R, Naidub V, Shastri N. Fast dissolving drug-drug eutectics with improved compressibility and synergistic effect. European Journal of Pharmaceutical Sciences. 2017;104: 82–89.
4. Kapoor B, Kaur R, Kour S, Behl H, Kour S. Solid Dispersion: An Evolutionary Approach for Solubility Enhancement of Poorly Water Soluble Drugs, International Journal of Recent Advancement in Pharmaceutical Research. 2012; 2(2): 1-16.
5. Schultz DA. 2008. Crystal Engineering of Co-crystals of Curcumin. Sixth Annual Raymond N. Castle Student Research Conference. Department of Chemistry, University of South Florida, 2008.
6. Elbagerma M. A, Edwards H. G. M, Munshi T, Scowen I.J. Identification of a new co-crystal of salicylic acid and benzamide of pharmaceutical relevance, Analytical and Bioanalytical Chemistry, 2010;397:137–146. DOI 10.1007/s00216-009-3375-7
7. Handler N, Jaeger W, Puschacher H, Leisser K, Erker T. Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors. Chemical and Pharmaceutical Bulletin. 2007; 55: 64—71.
8. Sanphui P, Goud N.R, Khandavilli U.B.R, Nangia A. Fast dis-solving curcumin cocrystals, Crystal Growth and Design. 2011;11: 4135– 4145, doi:10.1021/cg200704s
9. Lahamage SR, Darekar AB, Saudagar RB. Pharmaceutical Co-Crystallization. Asian Journal of Research Pharmaceutical Sciences. 2016;6(1): 51-58.
10. Samreen A, Riyaz M, Asiya A, Rasheed N, Mohammad AS. An Overview of Various Subjects Included as Syllabus for B. Pharmacy Students by JNTUH for its Definitions, Significance, Objectives and Outcomes. Asian Journal of Research Pharmaceutical Sciences. 2017; 7(1): 38-48.
11. Bhoi GS, Pimpodkar NV. Spherical Crystallization: Novel Technique. Asian Journal of Pharmacy and Technology. 2014;4(3): 151-156.
12. Ahmed MA, Rhgigh AM, Shakeel F. Effect of Surfactants on the Crystal Properties and Dissolution Behavior of Aspirin. Asian Journal of Research in Chemistry. 2009;2(2): 202-206.
13. Nagaraju Rajana N, Pallavi V, Madhavan P, Mohan HR, Babu HM, Basavaiah K. Absolute Configuration of Boceprevir Chiral fragment-B by Chiral Chromatographic, Spectroscopic, Thermal and Crystallization Techniques. Asian Journal of Research in Chemistry. 2018;11(3): 671-680.
14. Chaudhari P, Uttekar P, Waria N, Ajab A. Study of Different Crystal Habits Formed by Recrystallization Process and Study Effect of Variables. Research Journal of Pharmacy and Technology. 2008;1(4): 381-385.
15. Patil SV, Sahoo SK. Spherical Crystallization: a Method to Improve Tabletability. Research Journal of Pharmacy and Technology. 2009;2 (2): 234-237.
16. Muddukrishna BS, Bhat K, Shenoy GG. Preparation and Solid State Characterization of Paclitaxel Cocrystals. Research Journal of Pharmacy and Technology. 2014;7(1): 64-69.
17. Thati J, Chinta S. A Review on Spherical Crystallization Mechanisms and Characterization. Research Journal of Pharmacy and Technology. 2018; 11(1): 412-417. doi: 10.5958/0974-360X.2018.00076.8