Author(s):
Bhuwanendra Singh, Jitendra Gupta, Rohit Mohan, Reena Gupta, Kanchan Pal
Email(s):
bhuwanendrasingh14@gmail.com
DOI:
10.52711/0974-360X.2021.00510 
Address:
Bhuwanendra Singh1*, Jitendra Gupta2, Rohit Mohan3, Reena Gupta2, Kanchan Pal4
1Department of Pharmacognosy, NKBR College of Pharmacy and Research Centre,
Meerut, Uttar Pradesh, India- 245206.
2Institute of Pharmaceutical Research, GLA University, Mathura-281406, Uttar Pradesh, India-281406.
3Department of Pharmacology, Goel Institute of Pharmacy and Sciences, Lucknow, U.P, India-226028.
4Department of Biochemistry, Jhunjhun Wala, P.C College, Ayodhya, Faizabad- India-224001.
*Corresponding Author
Published In:
Volume - 14,
Issue - 5,
Year - 2021
ABSTRACT:
The current review article is based on the facts to reveal the biological potentials of the genus ledum, and specie palustre. Although in the article all the species are well described with their distribution in all over the world and their pharmacological activities are also discussed. Rhododendron tomantosum is also known as Marsh Tea or northern Labrador tea, which is an evergreen shrub having the height of about 40 cm and the plant has about ten species in all over the world. Article has very informative aspect regarding Hypouricemic Significance of Ledum palustre (L. palustre), its chemical compounds extracted and analyzed by different spectroscopic and chromatographic techniques to report the active principles from the oil of the Rhododendron tomantosum fresh leaves. The main active compounds were found are given as (41.0–43.4%) ledol (23.3–26.7%) and ascaridole (15.1–4.5%). L. palustre has a very significant role in the gout and arthritis occurs due the presence of high amount of uric acid in the blood plasma. Various dosage forms are mentioned in the review article to explore the potentials of the drug. Hence according to literature if L. palustre is significantly capable to reduce the high level of the uric acid if give in the potency if 30 c (diluted 30 times)) and 1 M ((1000 dilutions) to the patients, and may be a good alternative to the allopurinol. So, this drug is frequently used in the homeopathic system of medicine to get the hypouricemic significance in the human beings.
Cite this article:
Bhuwanendra Singh, Jitendra Gupta, Rohit Mohan, Reena Gupta, Kanchan Pal. Hypouricemic Significance of Ledum Palustre (Marsh Tea): A Review. Research Journal of Pharmacy and Technology. 2021; 14(5):2907-2. doi: 10.52711/0974-360X.2021.00510
Cite(Electronic):
Bhuwanendra Singh, Jitendra Gupta, Rohit Mohan, Reena Gupta, Kanchan Pal. Hypouricemic Significance of Ledum Palustre (Marsh Tea): A Review. Research Journal of Pharmacy and Technology. 2021; 14(5):2907-2. doi: 10.52711/0974-360X.2021.00510 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-5-94
REFERENCES:
1. Munjal Y. API Textbook of Medicine. The Association of Physicians. 9th ed: New Delhi India. 2012.
2. Shaffique S, Ahmed S, Rehman T, Mumtaz W, Anwar H, and Husain G. Anti-hyperuricemic potential of Rhododendron tomentosum Harmaja syn Ledum palustre L 30c and 1M in potassium oxonate induced rat model. Indian Journal of Traditional Knowledge. 2018; 17 (1): 724-731.
3. URL: https://en.wikipedia.org/wiki/Labrador_tea (Accessed on April 28, 2020)
4. Ren G, Chang W, Miao T, Wang C. Investigation and Utilization of Ledum palustre L Resources in the North Temperate Zone. IOP Conf. Series: Earth and Environmental Science 371. 2019; 032053.
5. Zhang L, Wang, Xu M, Hu1 X. Chemical Composition and Antibacterial Activity of the essential Oil from Chinese Wild Ledum palustre L on Vibrio Parahaemolyticus, International Journal of Food and Nutritional Science. 2017; 4 (1): 8- 12.
6. Kim D, Nam B. Extracts and essential oil of Ledum palustre L and their antioxidant and antimicrobial activities Journal of Food ScienceNutrition. 2006; 11(2): 100-104.
7. Evstratova RI, Kabanov VS, Krylova IL. and Prokosheva L.I. Content of Essential Oil and of Ledol in Leaves of Marsh Rosemary (Ledum palustre L.) during Different Phases of Vegetation. Pharmaceutical Chemistry Journal. 1978; 12: 1468-1473.
8. Kron KA, Judd WS. Phylogenetic relationships within the Rhodoreae (Ericaceae) with specific comments on the placement of Ledum. Syst Bot. 1990; 15: 57–68.
9. Harmaja H. Taxonomic notes on Rhododendron subsection Ledum (Ledum, Ericaceae), with a key to its species. Ann Bot Fenn. 1991; 28: 171–173.
10. Dampc A, Luczkiewicz M. Rhododendron tomentosum (Ledum palustre). A review of traditional use based on current research. J. Sci. Fitoterapia. 2013; 83: 130-143.
11. Gretsusnikova T, Jarvan K, Orav A, Koel M. Comparative analysis of the composition of the essential oil from the shoots, leaves and stems the wild Ledum palustre L. from Estonia. Procedia Chem. 2010; 2:168–173.
12. Dampc A and Luczkiewicz M. Labrador tea – the aromatic beverage and spice: a review of origin, processing and safety. J Sci Food Agric. 2014.
13. Collin G. Aromas from Quebec. IV. Chemical composition of the essential oil of Ledum groenlandicum: A review. American Journal of Essential Oils and Natural Products. 2015; 2 (3): 06-11.
14. Li S, Brault A, Villavicencio SM and Haddad PS. Rhododendron groenlandicum (Labrador tea), an antidiabetic plant from the traditional pharmacopoeia of the Canadian Eastern James Bay Cree, improves renal integrity in the diet induced obese mouse model. Pharmaceutical Biology. 2016.
15. Baananou S, Bagdonaite E, Marongiu B, Piras A, Porcedda S, Falconieri D and Boughatta NA. Supercritical CO2 extract and essential oil of aerial part of Ledum palustre L. Chemical composition and anti-inflammatory activity. Natural Product Research. 2014; 1-7.
16. Butkiene R, Sakociute V, Latvėnaite D, Mockute D. Composition of young and age shoot essential oils of the wild Ledum palustre L. Chemija. 2008; 19: 19–24.
17. Klokova MV, Khan VA, Dubovenko ZhV, Pentegova VA, Berezovskaya TP, Serykh EA. Terpenoids of the essential oil of Ledum palustre. Chem Nat Compd.1983; 19: 278–81.
18. Wang CP, Wang Y, Wang X, Zhang X, Ye JF, Hu LS and kong LD. mulberroside a possesses protein uricosuric and nephroprotetive effects in hyperuricemic mice. Plant Med. 2011; 77 (8): 786-794.
19. Harris M, Siegel L and Alloway J. Gout and hyperuricemia, am family physician.1999; 59: 925-934.
20. Ahmad M, Faraazi A and Aamir MN. The effect of Ocimum sanctum and Ledum palustre on serum uric acid level in patients suffering from gouty arthritis and hyperuricaemia. Bull Chem Soc. 2103; 27 (3): 469-473.
21. Nandy P, Bandyopadhyay P, Chakraborty M, Dey A, Bera D, Paul B, Kar S, Gayen A, Basu R and Das S. Homeopathic Nanomedicines and Their Effect on the Environment. Handbook of Environmental Materials Management. 2018; 1-23.
22. Cara R, A Research report submitted to the faculty of health sciences, in partial fulfillment of requirements for the degree of Master of technology homeopathy.Technikon Witwatersrand, Johannesburg. 2003.
23. Rose B, Gout, homeopathy. 1999; 49 (3): 50-51.
24. Jouanny J. the essentials of homeopathic Materia medica, S. A, France, Boiron. 1984; 67, 69, 85, 105.
25. Gibson D, studies of homeopathic remedies, Great Britain: university press oxford. 1987; 51, 54, 101, 102, 148,149, 150, 309.
26. Parveen S, A retrospective study of homoeopathic treatment in patients with heel pain with or without Calcaneal Spur Indian Journal of Research in Homoeopathy. 2107; 11 (1): 64-73.
27. Sato Y. 1990. Studies on chemical protectors against radiation. XXXI. Protection effects of Aloe arborescens on skin injury induced by x-irradiation. Yakugaku Zasshi. 110: 876– 884.