Author(s): Febriyenti, Almahdy A, Riska Ropika Hasibuan

Email(s): febriyenti74@yahoo.com , febriyenti@phar.unand.ac.id

DOI: 10.52711/0974-360X.2021.00573   

Address: Febriyenti*, Almahdy A, Riska Ropika Hasibuan
Faculty of Pharmacy, Universitas Andalas, Padang, West Sumatera, Indonesia 25163.
*Corresponding Author

Published In:   Volume - 14,      Issue - 6,     Year - 2021


ABSTRACT:
Eel (Monopterus albus) is a freshwater fish that is rich with protein, amino acids, and fatty acids, which are useful as nutrients for accelerated wound healing. The gel is a semisolid dosage form that produces a membrane on the surface of the wound that serves as a wound dressing. Other dosage forms namely membrane has a function to cover the wound and also contain nutrients that play an important rule in accelerating wound healing. The Eel was extracted by a water solvent in an autoclave at 121°C for 15 minutes. Eel extract was formulated in a gel and membrane dosage form. Then there are test the effectiveness of the Eel extract gel and membrane on incision wound healing using commercial preparations (gel dosage form) as positive control and without medication as the negative control. The efficacy of Eel extracts from each dosage form could be seen from rat skin that has slashed in the back section taken on days 3, 6, 9, and 12. Eel extract formulated in the membranes form provides the highest value of the tensile strength test. Gel and membrane of Eel extract have effectiveness toward the healing of incision wound in rat compared with the positive control.


Cite this article:
Febriyenti, Almahdy A, Riska Ropika Hasibuan. Efficacy of Eel (Monopterus albus) Extract Gel and Membrane on Incision Wound Healing. Research Journal of Pharmacy and Technology. 2021; 14(6):3295-8. doi: 10.52711/0974-360X.2021.00573

Cite(Electronic):
Febriyenti, Almahdy A, Riska Ropika Hasibuan. Efficacy of Eel (Monopterus albus) Extract Gel and Membrane on Incision Wound Healing. Research Journal of Pharmacy and Technology. 2021; 14(6):3295-8. doi: 10.52711/0974-360X.2021.00573   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-6-63


REFERENCES:
1.    Boateng J.S, Matthews K.H, Stevens H.N.E, Eccleston G.M. Wound healing dressings and drug delivery systems: A review. J Pharm Sci. 2008; 97(8): 2892-923.
2.    Cockbill S. Wounds-The Healing Process. Hospital Pharmacist. 2002; 9: 255-60.
3.    Cockbill S.M.E. Dressings in Wound Management. In: Swarbrick J, editor. Encyclopedia of Pharmaceutical Technology. Third edition New York: Informa Healthcare; 2007. p. 1023 - 37.
4.    Romo T, Pearson JM, Yalamanchili H, Zoumalan RA. Wound Healing, Skin2008 July 22, 2010]: Available from http://emedicine.medscape.com/article/884594-overview.
5.    Molnar JA. Overview of Nutrition and Wound Healing. In: Molnar JA, editor. Nutrition and Wound Healing. Boca Raton: CRC Press; 2007. p. 1 - 14.
6.    Diegelmann RF, Evans MC. Wound healing: an overview of acute, fibrotic, and delayed healing. Frontiers in Bioscience. 2004;9: 283-9.
7.    NHSH Senior Management Team. 2013. Nhs Highland Wound Management Guidelines and Formulary. NHS HIGHLAND.
8.    Marques SR, Peixoto CA, Messias JB, Albuquerque ARd, Junior VAdS. The effects of topical application of sunflower-seed oil on open wound healing in lambs. Acta Cir Bras. 2004;19(3): 191-203.
9.    Williams JZ, Barbul A. Nutrition and wound healing. Surg Clin N Am. 2003; 83: 571-96.
10.    Vijayabhaskar K, Sravanprasad M, Goli.  Venkateshwarlu, Devi PS, Kumar KH, Sunil. J. Wound Healing Activity of Bauhinia purpurea in Albino Wistar Rats. Asian J Res Pharm Sci. 2011; 1(2): 47-9.
11.    Sharma RK, G.P. R, Nathiya D, Sharma AK. Assessment of wound healing activity of roots of Bauhinia variegata Linn. by excision and incision model in Albino Rats. Asian J Res Pharm Sci. 2015;5(3): 145-52.
12.    Kumar D, Prasad D, Dua J, Bhatnagar S. Evaluation of Wound Healing Activity of Ethanolic Extract of Aerva tomentosa Forsk. Research J Pharmacognosy and Phytochemistry. 2009; 1(3): 188-90.
13.    Bagad YM, Bhurat MR, Tatiya AU, Surana SJ, Barhate SD. Evaluation of antioxidant and wound healing activity of the leaves of Bridelia airyshawii spreng. Research J Pharm and Tech. 2013; 6(4): 351-5.
14.    Karwani G, Singhvi IJ, S.K. Gupta, Agarwal A. Wound Healing Activity of Hydroalcoholic Extract of Acacia catechu. Research J Pharm and Tech. 2011;4(6): 905-6.
15.    Paswan SK, Srivastava S, Rao CV. Incision Wound healing, Anti-inflammatory and Analgesic activity of Amaranthus spinosus in Wistar rats. Research J Pharm and Tech. 2020; 13(5): 2439-44.
16.    Laila L, Febriyenti F, Salhimi SM, Baie S. Wound healing effect of Haruan (Channa striatus) spray. International Wound Journal. 2011; 8(5): 484-91.
17.    Febriyenti, Almahdy A, Mulyani D. Amino acids and fatty acids profiles of Eel (Monopterus albus) water extracts. Rasayan Journal of Chemistry. 2019; 12(3):in press.
18.    Razak ZKA, Basri M, Dzulkefly K, C.N.A. Extraction and Characterization of Fish Oil from Monopterus Albus. Malaysian Journal of Analytical Sciences. 2001; 7(1): 217 - 20.
19.    Carter SS. Dispensing Pharmaceutical Student. 12th ed. 1975, London: Pittman Medical.
20.    Lieberman, H.A., 1989. Pharmaceutical Dosage Forms – Disperse System. Marcel Dekker Inc.
21.    USP, The United States Pharmacopeia XXX - The National Formulary XXV. 2007, United States Pharmacopeial Convention, Inc.: Rockville.
22.    Swarbrick J, and Boylan JC, Encyclopedia of Pharmaceutical Technology. 1992, Marcel Dekker, Inc.: New York.
23.    Czaja W, Krystynowicz A, Bielecki S, Brown JRM. Microbial cellulose--the natural power to heal wounds. Biomaterials. 2006; 27(2): 145-51.
24.    Stashak TS, Farstvedt E, Othic A. Update on wound dressings: Indications and best use. Clinical Techniques in Equine Practice. 2004; 3(2): 148-63.
25.    Santos KSCR, Coelho JFJ, Ferreira P, Pinto I, Lorenzetti SG, Ferreira EI, et al. Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan. Int J Pharm. 2006; 310(1-2): 37-45.
26.    Febriyenti, Almahdy A, Dwi Mulyani, Formulation of Eel (Monopterus albus) extract gels for accelerated the wound healing, Scientia Jurnal Farmasi dan Kesehatan. 2020; 10(2): in press
27.    Febriyenti, Rahmi Nofita, Khalidazia, Formulation of Eel (Monopterus albus) extract membrane for wound dressing using plasticizer, Jurnal Sains Farmasi dan Klinis. 2020; 7(1): 1-4
28.    Deacon RMJ. Housing, husbandry and handling of rodents for behavioral experiments. Nat Protoc. 2006;1(2):936-46.
29.    Yregard L, Lowhagen PH, Cassuto J, Nilsson U, Lindblom L, Rantfors J, et al. A new technique for the analysis of endogenous mediators released following thermal injury. Burns. 2001; 27: 9-16.
30.    Olfert ED, Cross BM, McWilliam AA, editors. Guide to the care and use of experimental animals 2nd ed. Ottawa: Canadian Council on Animal Care; 1993.
31.    Prasad V, Dorle AK. Evaluation of ghee based formulation for wound healing activity. J Ethnopharmacol. 2006; 107(1): 38-47.
32.    Reddy JS, Rao PR, Reddy MS. Wound healing effects of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica in rats. J Ethnopharmacol. 2002; 79(2): 249-51.
33.    Singh M, Govindarajan R, Nath V, Rawat AKS, Mehrotra S. Antimicrobial, wound healing and antioxidant activity of Plagiochasma appendiculatum Lehm. et Lind. J Ethnopharmacol. 2006; 107(1): 67-72.
34.    Akkol EK, Koca U, Pesin I, Yilmazer D, Toker G, Yesilada E. Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models. Journal of Ethnopharmacology. 2009; 124(1): 137-41.
35.    Jauregui KMG, Cabrera JCC, Ceniceros EPS, Hernandez JLM, Ilyina A. A new formulated stable Papin-pectin aerosol spray for skin wound healing. Biotechnology and Bioprocess Engineering. 2009;14: 450 - 6.
36.    Gomez-Beloz A, Rucinski JC, Balick MJ, Tipton C. Double incision wound healing bioassay using Hamelia patens from El Salvador. J Ethnopharmacol. 2003; 88(2-3): 169-73.
37.    Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol. 1999; 65(1): 1-11.
38.    Febriyenti, Henny Lucida, Almahdy A, Istianah Alfikriyah, Muhammad Hanif, Wound Healing Effect of Honey Gel and Film, Journal of Pharmacy and Bioallied Sciences. 2019, 11(2): 176-180
39.    MacKay D, Miller AL. Nutritional Support for Wound Healing. Alternative Medicine Review. 2003; 8(4): 359-77.
40.    Baie SH, Sheikh KA. The wound healing properties of Channa striatus-cetrimide cream -- tensile strength measurement. J Ethnopharmacol. 2000; 71(1-2): 93-100.
41.    Ghori SS, Gouse M, Panda N, Khaled S, Basheeruddin S, Baig MD, et al. Wound Healing Activity of Poly Herbal formulation. Res J Pharm Dosage Form and Tech. 2015; 7(2): 125-8.
42.    Rachmasari A, Kartini RA, Alviani G, Solihah I. Healing effect of Spray gel collagen extract from Channa striata bone on burn in rats. Res J Pharma Dosage Forms and Tech. 2019; 11(4): 275-9.
43.    Daphne TL, Prince V. A Study to assess the Effectiveness of Aloe Vera Gel Dressing on Wound Status among Patients with Diabetes Mellitus in Government Hospital, Dindigul. Int. J. of Advances in Nur. Management. 2019; 7(2): 159-62.
44.    Saudagar RB, Gangurde. PA. Formulation, Development and Evaluation of Film-Forming Gel for Prolonged Dermal Delivery of Miconaole Nitrate. Research J Topical and Cosmetic Sci 2017; 8(1): 19-29.

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