Author(s): P. Aravanan, S Jayakumari


DOI: 10.52711/0974-360X.2021.00579   

Address: P. Aravanan1*, S Jayakumari2
1School of Pharmaceutical Sciences, Vel’s Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai.
2Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University, Chennai - 600117.
*Corresponding Author

Published In:   Volume - 14,      Issue - 6,     Year - 2021

Objective: To evaluate cytotoxic and antioxidant activity of the plant Bauhinia racemosa root by in-vitro cell line analysis. Methods: MCF-7 cell lines were used for the study to find the inhibitory concentration of the extract. DPPH and NO scavenging assays were performed to study the antioxidant nature of the extract. Results and Conclusion: In MCF-7 cell line cytotoxicity effect was observed in tested sample concentrations in 48 hours treatment, it also revealed that increased concentration of drug shown increased cytotoxicity over the MCF-7 cell lines. DPPH and NO scavenging Assay revealed a concentration dependent radical scavenging capacity of the tested sample concentrations of Bauhinia racemosa root spectrophotometrically.

Cite this article:
P. Aravanan, S Jayakumari. In-vitro Cytotoxic and Antioxidant Activity of Bauhinia racemosa Root. Research Journal of Pharmacy and Technology. 2021; 14(6):3333-6. doi: 10.52711/0974-360X.2021.00579

P. Aravanan, S Jayakumari. In-vitro Cytotoxic and Antioxidant Activity of Bauhinia racemosa Root. Research Journal of Pharmacy and Technology. 2021; 14(6):3333-6. doi: 10.52711/0974-360X.2021.00579   Available on:

1.    Kokate CK, Practical Pharmacognosy. 5th Ed, Vallabh Prakashan, Delhi.1991.
2.    Kulkarni SK. Hand book of Experimental Pharmacology, Vallabh Prakashan, Delhi. 1991.
3.    Asima Chatterjee, Satyesh Chandra Pakrashi, The Treatise of Indian Medicinal Plants. Vol.2, Publication and Information Directorate, CSIR, New Delhi, 1992.
4.    Manoranjan Sharma H, Radhapyari Devi A, and Manihan Sharma B, Vegetable drugs used by the Meitei community of Manipur, Indian Journal of Traditional Knowledge, 2005.
5.    Nadkarni KM, Indian Materia Medica, Bombay Popular Prakashan, 1982.
6.    H. Lata, G.K Ahuja. Role of free radicals in health and disease. Indian Journal of Physiology and Allied Sciences. 2003; 57:124.
7.    Sandip K Bandyopadhyay, et al., The role of antioxidant activity of Phyllanthus emblica fruits on prevention from Indomethacin induced gastric ulcer, Journal of Ethnopharmacology.2003; 70(2): 171-176.
8.    Sangilimuthu Alagar Yadav, et al., Antioxidant activity of Withania somnifera (L) Dunal by different solvent extraction methods, Journal of Pharma Research, 2011; 4(5): 1426-1428.
9.    Verma S, Siriha Kumar. Study of Convolvulus pluricaulis for antioxidant and anticonvulsant study, Central Nervous System Agents in Medicinal Chemistry. 2012; 12(1): 55-59.
10.    Noor Nazirahanir Abrahim, et al., Piper betel shows antioxidant activities inhibits MCF-7 cell proliferation and increases activities of Catalase and Superoxide dismutase, BMC Complementary and Alternative Medicine, 2012; 12:220.
11.    Harborne, J. B., Phytochemical Methods, third ed.,  A guide to modern techniques of plant analysis, Springer Pvt Ltd, New Delhi, India, 2007.
12.    Armatu et al, Evaluation of antioxidant and free radical scavenging potential of some Lamiaceae species growing in Romania, Romanian Biologiacal Letters. 2010; 15(3):5274, 5280.
13.    Medina JH, et al., Overview-flavonoids: A new family of benzodiazepine receptor ligands. Neurochemistry, 1997; 22 (4): 419-425.
14.    Yen GC, Duh PD. Scavenging effect of Methanolic extract of Peanut hulls on Free radical and Active Oxygen species. Jouranl of Agricultural and Food Chemistry1994; 42(3):629-32.
15.    Nilimma S. Rajurkar, S.M. Hande. Estimation of Phytochemical Content and Antioxidant Activity of Some Selected Traditional Indian Medicinal Plants. Indian Journal of Pharmaceutical Sciences. 2011; 73(2): 146-151.
16.    Stanley Mukanganyama. Evaluation of Nitrite Radical Scavenging Properties of Selected Zimbabwean plant Extracts and Their Phytoconstituents. Journal of Food Processing. 2014.
17.    Okoye T.C, et al., (2010). Evaluation of the Anticonvulsant and Muscle Relaxant Effects of the Methanol Root Bark Extracts of Annona senegalensis. Asian Pacific Journal of Tropical Medicine. 2010; 3(1): 25-28.
18.    Gribel G, et al., Pharmacological Studies on Synthetic Flavonoids: Comparison with Diazepam. Neuropharmacology. 1999; 38(7): 965-977.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available