Author(s): Ajay Choudhary, Rajesh Sharma, Ashok Kumar, Kuldeep Kinja, Ravi Berwal, Swapnil Sharma

Email(s): ashujinagal12@gmail.com

DOI: 10.52711/0974-360X.2021.00672   

Address: Ajay Choudhary2, Rajesh Sharma2, Ashok Kumar1*, Kuldeep Kinja3, Ravi Berwal4, Swapnil Sharma1
1Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan - 304022, India.
2Department of Neurosurgery, Atal Bihari Vajpayi Institute of Medical Sciences, Dr. R.M.L. Hospital, New Delhi - 110001, India.
3Cliniminds Institute of Health Sciences, Noida, U.P - 201301, India.
4Guru Jambheshwar University and Science Technology, Hisar - 125001, Haryana, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
Objective: To study the prevalence of 25-hydroxyvitamin D deficiency pattern during three year (2017-2020) and severity correlation among individuals with acute traumatic brain injury (TBI). Methodology: Subjects with acute TBI admitted from June 1st, 2017 through June 30th, 2020 were recruited. 280 out of 445 met inclusion criteria. The demographic injury related details, assessment of 25 OH vitamin D and Glasgow Comma (GCS) score were done at the time of admission. Results: The year wise enrolled subjects were young with mean age of 28.39±0.86 years with males (73.3%) and female (23.7%), in first year, 27.77±5.35 years with males (81.67%) and female (18.33%), in second year and 23.04±7.10 years with males (88.57%) and female (11.42%), in third years. Mean value of 25(OH) vitamin D in subjects during three years were 23.78±11.79ng/mL, 21.65±12.53 ng/mL and 25.18±18.58ng/mL. The vitamin D deficiency levels in this study were tabulated as: deficient (level <20 ng/mL), insufficient (level 20–29.9ng/mL), and sufficient (level =30ng/mL). Which were found during three years as: In First year, Deficient (64.44%), Sufficient (11.11%), insufficient (24.44%), in second years, Deficient (88.33%), Sufficient (2.66%), insufficient (10.00%) and in third year Deficient (88.57%), Sufficient (1.42%), insufficient (10.00%). In which sufficient level were found to be decreased statistically significant with years with P value= 0.0001. The severity assessment through GCS score were found to be statistically increased with deficient levels with P values=0.0447, but found no significance, when comparison were done between years wise GCS score and levels of vitamin D. Conclusion: The study found decreased prevalence of vitamin D deficiency levels with increased severity. Therefore it should be routinely screened and treated as indicated.


Cite this article:
Ajay Choudhary, Rajesh Sharma, Ashok Kumar, Kuldeep Kinja, Ravi Berwal, Swapnil Sharma. Prevalence of 25-Hydroxyvitamin D Deficiency and its severity correlation with Acute Traumatic brain Injury in Indian Patients: A Perspective Observation Study. Research Journal of Pharmacy and Technology. 2021; 14(7):3874-8. doi: 10.52711/0974-360X.2021.00672

Cite(Electronic):
Ajay Choudhary, Rajesh Sharma, Ashok Kumar, Kuldeep Kinja, Ravi Berwal, Swapnil Sharma. Prevalence of 25-Hydroxyvitamin D Deficiency and its severity correlation with Acute Traumatic brain Injury in Indian Patients: A Perspective Observation Study. Research Journal of Pharmacy and Technology. 2021; 14(7):3874-8. doi: 10.52711/0974-360X.2021.00672   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-7-69


REFERENCES:
1.    Utiger R D. The need for more Vitamin D. N. Engl. J. Med. 1998; 338: 828–829.
2.    Aparna P, Muthathal S, Nongkynrih B, Gupta SK. Vitamin D deficiency in India. J Family Med Prim Care. 2018; 7(2): 324‐330.
3.    Sharma S, Kumar A, Choudhary A, Sharma S, Khurana L, Sharma N, et al. Neuroprotective role of oral vitamin D supplementation on consciousness and inflammatory biomarkers in determining severity outcome in acute traumatic brain injury patients: A Double-Blind Randomized Clinical Trial. Clin. Drug. Investig. 2020; 40: 327–334.
4.    Jamall A, Feeney C, Zaw, Linn J, Malik A, Niemi E K, et al. Prevalence and correlates of vitamin D deficiency in adults after traumatic brain injury. Clin. Endocrinol. 2016; 85(4): 636-644.
5.    Toman E, Bishop J, Davies D, Su Z, Criseno S, Mason A, et al. Vitamin D deficiency in traumatic brain injury and its relationship with severity of injury and quality of Life: a prospective, observational Study. J. Neurotrauma. 2017; 1(7): 1448-1456.
6.    Atif F, Sayeed I, Ishrat T, Stein DG. Progesterone with Vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone. Mol Med. 2009; 15: 328-36.
7.    Kadoura S, Alhalabi M, Nattouf A H. Effect of calcium and vitamin D supplements as an adjuvant therapy to metformin on lipid profile in vitamin D deficient/insufficient polycystic ovary syndrome patients: A Randomized, Placebo-Controlled Clinical Trial. Research J. Pharm. and Tech. 2019; 12(5):2 327-2332.
8.    Shah P, Kulkarni S, Sureka SND, Dutta S, Vipat AS, et al. Prevalence Study of vitamin D deficiency and to evaluate the efficacy of vitamin D3 granules 60,000 IU supplementation in vitamin D deficient apparently healthy adults. Indian J Clin Pract. 2013 May; 23(12): 827-832.
9.    Subashree R., Arjunkumar R. Vitamin D Deficiency in Periodontal Health. Research J. Pharm. and Tech. 7(2): Feb. 2014; Page 248-252.
10.    Van der Schaft, J., Koek, H., Dijkstra, E., Verhaar, H., Van der Schouw, Y., & Emmelot-Vonk, M. The association between vitamin D and cognition: a systematic review. Ageing Res. Rev.2013; 12 (4), 1013-1023.
11.    Burje S, Rungta S, Shukla A. Detection and Classification of MRI Brain Images for Head/Brain Injury Using Soft Computing Techniques. Research J. Pharm. and Tech. 2017; 10(3): 715-720.
12.    Povlishock, J. T., and Katz, D. I. Update of neuropathology and neurological recovery after traumatic brain injury. J Head Trauma Rehab.2005; 20(1): 76-94.
13.    Shinchuk, L. M., Morse, L., Huancahuari, N., Arum, S., Chen, T. C., & Holick, M. F. Vitamin D deficiency and osteoporosis in rehabilitation inpatients. Arch. Phys. Med. Rehabil.2006; 87(7): 904-908.
14.    Oretha Istiqomah Sunarto, Abdul Hafid Bajamal, Abdurachman. Outcome of Brain Injury Patients After Decompressive Craniectomy in Tertiary Referral Hospital in East Java Indonesia. Research J. Pharm. and Tech. 2019; 12(12): 6057-6061.
15.    Gururaj G, Kolluri S.V.R, Chandramouli B.A, Subbakrishna D.K, Kraus JF. Traumatic Brain Injury. National Institute of Mental Health & Neuro Sciences, Publication no. 61, Bangalore - 560029, India. 2005.
16.    Udekwu P, Schiro SK, Vaslef, Baker C, Oller D. Glasgow coma scale score, mortality and functional outcome in head injured patients. J. Trauma. 2004; 56 (5):1084-1089.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available