Author(s): Rasheed Ahemad Shaik, Syed Jaffer, Syeda Humera Fatima

Email(s): psrivastava@amity.edu

DOI: 10.52711/0974-360X.2021.00679   

Address: Dr. Rasheed Ahemad Shaik1, Dr. Syed Jaffer2, Syeda Humera Fatima3
1Associate Professor, Department of Pharmacology and Toxicology, King Abdul Aziz University Jeddah, Saudi Arabia.
2Assisstant Professor, Department of Pharmacy, Sultan-ul-uloom College of Pharmacy, Hyderabad-Telangana, India.
3Student, Sultan-ul-Uloom College of Pharmacy, Hyderabad-Telangana, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 7,     Year - 2021


ABSTRACT:
Background: Tuberculosis is the oldest common infectious disease affecting not only lungs but several organs in a human body. Its caused by the bacteria Mycobacterium tuberculosis. Tuberculosis exposure is through lungs. This disease has co-morbid conditions. The basic treatment according to WHO is with Isoniazid, Rifampicin, Pyrazinamide, Ethambutol, but these drugs may lead to adverse drug reactions and drug interactions. Objective: To determine the adverse effects and drug-drug interactions post administration of anti-tubercular drugs and to determine the influence of drugs on their co-morbid conditions of patients suffering from tuberculosis in Aster Prime Hospital. Methods: The patient’s prescriptions of total 110 were collected from the outpatient and in-patient Pulmonology department. These were noted in the data collection form and the comparative study was done by evaluating the number of male and female affected with Tuberculosis, common drug-drug interaction with respective drug, adverse drug reaction followed by the common co-morbid condition occurring with TB and the effect of drugs on co-morbidities Results: The prevalence of tuberculosis in 110 patients was found to be more in females by 12% than males. The co-morbid conditions found with tuberculosis were Hypertension, diabetes, pleural effusion, hepatitis, cavitary disease and respiratory failure. The least common comorbidities were chronic obstructive pulmonary disease (COPD), gastritis, and stroke and chronic kidney disease (CKD) and ulcerative colitis. The total adverse effect found in the 62 patients (56.36%) and the patients with no adverse drug reactions were 48 (43.63%) The percentage of total drug-drug interactions found in the patients were 44% (n=48) and the percentage of patients with no interactions were 56% (n=62). Conclusion: Health care workers play an important role and considered as a vital group for tuberculosis awareness activities to increase competence in TB management and compliance with national guidelines. Interventions address a combination of varying influences on behaviour, focusing on specific gaps identified to improve their impact.


Cite this article:
Rasheed Ahemad Shaik, Syed Jaffer, Syeda Humera Fatima. Study on Prevalence of Adverse Drug Reactions and Drug-Drug Interactions and Co-Morbid Conditions of Patients Suffering from Tuberculosis. Research Journal of Pharmacy and Technology. 2021; 14(7):3911-5. doi: 10.52711/0974-360X.2021.00679

Cite(Electronic):
Rasheed Ahemad Shaik, Syed Jaffer, Syeda Humera Fatima. Study on Prevalence of Adverse Drug Reactions and Drug-Drug Interactions and Co-Morbid Conditions of Patients Suffering from Tuberculosis. Research Journal of Pharmacy and Technology. 2021; 14(7):3911-5. doi: 10.52711/0974-360X.2021.00679   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-7-76


REFERENCES:
1.    Elizabeth Kiefer, Theresa Shao, OlveenCarasquillo, Pamela Nabeta, Carlos Seas, Knowledge and attitudes of tuberculosis management in San Juan de Lurigancho district of Lima, Peru, J Infect DevCtries 2009; 3(10):783-788
2.    Advocacy, communication and social mobilization for TB control, A guide to developing knowledge, attitude and practice surveys, World Health Organization, Journal of National Tuberculosis Control, 225/32490
3.    Frederick AD Kaona, Mary Tuba, SeterSiziya and LenganjiSikaona .An assessment of factors contributing to treatment adherence and knowledge of TB transmission among patients on TB treatment, BMC Public Health 2004, 10.1186/1471-2458
4.    FlorieBarnhoorn, Hans Adriaanse .In search of factors responsible for noncompliance among tuberculosis patients in Wardha District, India, April 2001, 21.2342.
5.    R. Liefooghe, N. Michiels, S. Habib, M.B. Moran, A. De Muynck,Perception and social consequences of tuberculosis: A focus group study of tuberculosis patients in Sialkot, Pakistan, Journal of National Estraat, Institute of Tropical Medicine, Belgium, August 2003, 10.1189/172-2566
6.    D.S. Hashim, W. Al Kubaisy and A. Al Dulayme. Knowledge, attitudes and practices survey among health care workers and tuberculosis patients in Iraq Factors Influencing Adherence to Tuberculosis Directly Observed Therapy: A Review of the Literature,La Revue de Santé de la Méditerraneeorientale, Vol. 9, No 4, 2003, 234.25/8743-12
7.    Socio-economic determinants of knowledge and attitudes about tuberculosis among the general population of Metro Manila, Philippines, TB Journal Philippines, September 2007, 12.542/871.
8.    C. A. Bell, G. Duncan, B. Saini, Knowledge, attitudes and practices of private sector providers of tuberculosis care: a scoping review, Monash University, Melbourne, Australia. Journal-INT J TUBERC LUNG DIS 15(8):1005–1017 , 8 June 2011 .
9.    Fredrick AD Koana, Mary Tuba, SterSiziya and LengajiSikaona.An assessment of factors contributing to treatment adherence and knowledge of TB transmission among patients on TB treatment, British Medical Council, December 2004, 54/1245.
10.    Vijayaprasad Gopichandran, Priyankur Roy, Ashwin Sitaram, Karthick, and KR John. Impact of a Simple Educational Intervention on the Knowledge and Awareness of Tuberculosis among High School children in Vellore, India, Indian National Journal, Sept 2001, 12.2324/2445.
11.    R K Swamybbdo advertising Pvt. Ltd, baseline KAP study under RNTCP project to central TB division, Ministry of Health & Family Welfare Government of India. March 4th 2003, 783/8731.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available