Author(s):
Mohammed K.A.A, Wasfy A.A.F, Bazalou M. S
Email(s):
kareemhagag1010@gmail.com
DOI:
10.52711/0974-360X.2021.00748
Address:
Mohammed K.A.A1*, Wasfy A.A.F1, Bazalou M. S2
1Department of Chemistry, Faculty of Science, Benha University, Benha – Egypt.
2Animal Health Research Institute, Doky, Giza, Egypt.
*Corresponding Author
Published In:
Volume - 14,
Issue - 8,
Year - 2021
ABSTRACT:
This study was carried out to identify of the chemical constituent of ginger (Zingiber officinale Rosc), forty-eight compounds of ethanolic sonicated extract were identified by Gas Chromatography Triple Quad Time-Flight (GC-Q-TOF) analysis. Nineteen of these compounds existed studies on their biological activity, The main components were Zingiberone (4.12%) ,[10]-Shogaol(2.47%),Methyldiacetoxy-[6]gingerdiol(4.30%),[6]-Gingerdiol3,5 diacetate(7.77%), [6]-Gingerdiol (2E)-geranial acetal (2.76%), Campesterol (1.52%), Stigmasterol(1.71%),?-Sitosterol(4.46%),10S,11S-Himachala-3(12),4 diene(3.57%), Cubebol(2.01%), 3a,9ß-Dihydroxy-3,5a,8 trimethyltricyclo[6.3.1.0(1,5)]dodecane(2.24%),8-Amino-2,6 dimethoxylepidine(2.13%),17a-Ethynyl-17ß-hydroxy-5ß-estran-3-one(2.50%), Tributyl aconitate(2.34%), Ethyl 3,4-dimethoxy-N-(3-phthalimidopropionyl)-dl phenylalaninate (3.90%), Podocarpa-1,8,11,13-tetraen-3-one, 14-isopropyl-1,13-dimethoxy (12.51%), 2,4-Diamino-5,6-decamrthylenethieno[2,3-d]pyrimidine(3.65%) and trans-1-(p-(Methylthio)phenyl)-1-dodecen-3-one(6.68%). also minor compounds were present. From this result, it could be concluded that ginger (Zingiber officinale Rosc) contains various bioactive compounds which have various biological activities. Therefore, it is recommended as a plant of therapeutic importance.
Cite this article:
Mohammed K.A.A, Wasfy A.A.F, Bazalou M. S. Qualitative Analysis of Ethanolic extract of Ginger (Zingiber officinale Rosc) by Gas Chromatography Triple Quad Time-Flight (GC-Q-TOF) Technology. Research Journal of Pharmacy and Technology. 2021; 14(8):4307-3. doi: 10.52711/0974-360X.2021.00748
Cite(Electronic):
Mohammed K.A.A, Wasfy A.A.F, Bazalou M. S. Qualitative Analysis of Ethanolic extract of Ginger (Zingiber officinale Rosc) by Gas Chromatography Triple Quad Time-Flight (GC-Q-TOF) Technology. Research Journal of Pharmacy and Technology. 2021; 14(8):4307-3. doi: 10.52711/0974-360X.2021.00748 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-8-54
REFERENCES:
1 Helal MM, Osman MY, Ghobashy MO et al. Study of some biological activities of aqueous extract of ginger (Zingiber officinale). Egyptian Pharmaceutical Journal. 2014; 13(2): 144.
2 Semwal RB, Semwal DK, Combrinck S et al. Gingerols and shogaols: Important nutraceutical principles from ginger. Phytochemistry. 2015; 117: 554-68.
3 Sharma PK, Singh V and Ali M. Chemical composition and antimicrobial activity of fresh rhizome essential oil of zingiber officinale roscoe. Pharmacognosy Journal. 2016; 8(3).
4 Liu Y, Liu J and Zhang Y. Research progress on chemical constituents of zingiber officinale roscoe. BioMed Research International. 2019; 2019.
5 Nikolić M, Vasić S, Đurđević J et al. Antibacterial and anti-biofilm activity of ginger (Zingiber officinale (roscoe)) ethanolic extract. Kragujevac Journal of Science. 2014; (36): 129-36.
6 Pandey A and Tripathi S. Concept of standardization, extraction and pre phytochemical screening strategies for herbal drug. Journal of Pharmacognosy and Phytochemistry. 2014; 2(5).
7 Pop A-V, Tofana M, Socaci SA et al. Evaluation of antioxidant activity and phenolic content in different salvia officinalis l. Extracts. Bull UASVM Food Sci Technol. 2015; 72(2): 210-4.
8 Thongson C, Davidson P, Mahakarnchanakul W et al. Antimicrobial activity of ultrasound‐assisted solvent‐extracted spices. Letters in Applied Microbiology. 2004; 39(5): 401-06.
9 Yamuna P, Abirami P, Vijayashalini P et al. Gc-ms analysis of bioactive compounds in the entire plant parts of ethanolic extract of Gomphrena decumbens jacq. Journal of Medicinal Plants Studies. 2017; 5(3): 31-37.
10 Mostafa I, El-Aziz EA, Hafez S et al. Chemical constituents and biological activities of Galinsoga parvifl Ora cav.(asteraceae) from egypt. Zeitschrift für Naturforschung C. 2013; 68(7-8): 285-92.
11 Azad FR, Shafaghat A and Salimi F. Chemical constituents, antioxidant and antimicrobial activities of essential oil and hexane extract from Arnebia linearifolia dc. Seeds. Journal of Essential Oil Bearing Plants. 2014; 17(1): 87-94.
12 Ok S and Jeong W-S. Optimization of extraction conditions for the 6-shogaol-rich extract from ginger (Zingiber officinale roscoe). Preventive Nutrition and Food Science. 2012; 17(2): 166.
13 Panawan S, Watcharapong C, Sugunya M et al. Structures of phytosterols and triterpenoids with potential anti-cancer activity in bran of black non-glutinous rice nutrients. Nutrients. 2015; 7: 1672-87.
14 Sosa AA, Bagi SH and Hameed IH. Analysis of bioactive chemical compounds of euphorbia lathyrus using gas chromatography-mass spectrometry and fourier transform infrared spectroscopy. International Journal of Pharmacognosy and Phytochemical Research. 2016; 8(5): 109-26.
15 Ho C-L, Wang EI-C, Hsu K-P et al. Composition and antimicrobial activity of the leaf essential oil of Litsea kostermansii from Taiwan. Natural Product Communications. 2009; 4(8): 1934578X0900400822.
16 Chahal KK, Kaushal S and Sandhu AK. Chemical composition and biological properties of Chrysopogon zizanioides (L.) Roberty syn. Vetiveria zizanioides (L.) Nash-a review. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]. 2015; 6(4): 251-60.
17 Sarvesan R, Eganathan P, Saranya J et al. Chemical composition and antimicrobial activity of leaf essential oil of Syzygium grande (wight) walp. Journal of Essential Oil Bearing Plants. 2015; 18(3): 642-46.
18 Mischko W, Hirte M, Fuchs M et al. Identification of sesquiterpene synthases from the Basidiomycota coniophora puteana for the efficient and highly selective β-copaene and cubebol production in e. Coli. Microbial Cell Factories. 2018; 17(1): 164.
19 Ahmad B, Rehman MU, Amin I et al. A review on pharmacological properties of zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone). The Scientific World Journal. 2015; 2015.
20 Shelly A, Shikha M and Narayan SR. Chemical investigation of fatty acid, phenolic content in Arachis hypogaea, Anacardium occidentale, Prunus dulcis, Prunus armeniaca and comparison of their antibacterial activity with amoxicillin. 2015.
21 Kou X, Wang X, Ji R et al. Occurrence, biological activity and metabolism of 6-shogaol. Food & Function. 2018; 9(3): 1310-27.
22 Rahmani AH. Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities. International Journal of Physiology, Pathophysiology and Pharmacology. 2014; 6(2): 125.
23 Zhang X, Zhang S, Yang Y et al. Natural barrigenol–like triterpenoids: A comprehensive review of their contributions to medicinal chemistry. Phytochemistry. 2019; 161: 41-74.
24 Venkatesh R, Vidya R and Kalaivani K. Gas chromatography and mass spectrometry analysis of Solanum villosum (mill) (Solanaceae). International Journal of Pharmaceutical Sciences and Research. 2014; 5(12): 5283.
25 Jolad SD, Lantz RC, Chen GJ et al. Commercially processed dry ginger (Zingiber officinale): Composition and effects on lps-stimulated pge2 production. Phytochemistry. 2005; 66(13): 1614-35.
26 Leth T and Søndergaard H. Biological activity of vitamin e compounds and natural materials by the resorption-gestation test, and chemical determination of the vitamin e activity in foods and feeds. The Journal of Nutrition. 1977; 107(12): 2236-43.
27 Suttiarporn P, Chumpolsri W, Mahatheeranont S et al. Structures of phytosterols and triterpenoids with potential anti-cancer activity in bran of black non-glutinous rice. Nutrients. 2015; 7(3): 1672-87.
28 Tripathi N, Kumar S, Singh R et al.: OJC; 2013.
29 Tripathi N, Kumar S, Singh R et al. Isolation and identification of γ-sitosterol by gcms from the leaves of (decne). The Open Bioactive Compounds Journal. 2013; 4(1).