Author(s): Varsha Singh, Aleza Rizvi, Udaivir Singh Sara

Email(s): uvssaara@gmail.com

DOI: 10.52711/0974-360X.2021.00790   

Address: Varsha Singh1, Aleza Rizvi2, Udaivir Singh Sara1*
1Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Ghaila Road, Balrampur, Lucknow.
2Department of Pharmacognosy, Hygia Institute of Pharmacy, Ghaila Road, Balrampur, Lucknow.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
The present work focus to evaluate the physicochemical and preliminary phytochemical studies on the seeds of family Caricaceae. The plants resources which are used in pharmaceutical formulation standardization was carried out on the basis of organoleptic properties, physical characteristics, and physico-chemical properties. Different Physicochemical parameters ash values, extractive values, loss on drying, foreign matter, fluorescence analysis, and pH were evaluated. Macroscopical characteristics and Physicochemical parameters like total ash, acid insoluble ash and water soluble ash were found to be 83.7%, 71.7% and 61.5% w/w respectively. Hexane, ethyl acetate, ethanol and water soluble extractive values (hot)were 7.6%, 11.6%, 27.4%, 37.5%w/w respectively. The pH of 1% and 10% aqueous solution was found to be 3.57 and 3.78 respectively. Preliminary phytochemical screening showed the presence of Tannins, Proteins and amino acids, Glycosides, Phenolic compounds, Carbohydrates, Saponins, Alkaloids and Flavonoids. Thin layer chromatographic studies also had been done on ethanolic and hexane extracts. HPTLC fingerprinting is a valuable method for the quantitative determination of phytochemicals present in plant extract. These studies aim to investigating referential information for correct identification and standardization of this plant secondary metabolites.


Cite this article:
Varsha Singh, Aleza Rizvi, Udaivir Singh Sara. Standardization and Phytochemical screening of Carica papaya seeds. Research Journal of Pharmacy and Technology. 2021; 14(9):4540-6. doi: 10.52711/0974-360X.2021.00790

Cite(Electronic):
Varsha Singh, Aleza Rizvi, Udaivir Singh Sara. Standardization and Phytochemical screening of Carica papaya seeds. Research Journal of Pharmacy and Technology. 2021; 14(9):4540-6. doi: 10.52711/0974-360X.2021.00790   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-9-4


REFERENCES:
1.    Jagtap NS, Nalamwar VP, Khadabadi SS and Pratapwa AS. Phytochemical and Pharmacological Profile of Annona squamosa Linn: A Review. Research Journal of Pharmacognosy and Phytochemistry. 2009; 1(3): 139-142
2.    Hussain, A, Rizvi A, Wahab S, Zareen I, Ansari S and Hussain S. Antibacterial screening of the bark of Adenantherapavonina (L.). International Journal of Biomedical Research. 2011; 2(2): 110-121.
3.    Thorat Sheela S, Patil Poonam J. Phytochemical Analysis and Pharmacological Screening of Caralluma fimfriata wall. Whole Plant Extract. Res. J. Pharmacognosy and Phytochem. 2019; 11(4): 217-221.
4.    Wahab S, Hussain A, Ahmad P, and Rizvi, A. Current status of herbal drugs in the development of newer therapeutics agents. International Journal of Pharmaceutical and Chemical Sciences.2013; 2 (3): 1462-73.
5.    John AO, Okeniyi, Tinuade A, Oyeku A , Oyelami, Lateef, and A Adeyemi. Effectiveness of dried Carica papaya seeds against human intestinal parasitosis: Apilot. Study of Medicinal Food. 2007; 10(1): 194-196.
6.    Anusara NS, Zaharia SS, Taiba IA and MT Rahman. Effect of Green and Ripe Carica papaya Epicarp Extract on Wound Healing and During Pregnancy. Food and Chemical Toxicology.” Food and Chemical Toxicology. 2008; 46(7): 5.
7.    Gonsalves D, Balde A, Method to Control the Ripening of Papaya Fruit and Confer Disease Resistance to Papaya Plants, Google patents
8.    Jaiswal P, Jain B. Medicative Properties of Carica papaya – An Overview Review. International journal of pharmacy and pharmaceutical research. 2018; 13(1): 11-17
9.    Olagunju JA, Adeneye AA, and Fagbohunka BS. Nephroprotective activities of the aqeuous seed extract of Carica papaya Linn in carbon tetrachloride induced renal injured wistar rats: a dose-and time-dependent study. Biol and Med vol. (2009). (1): 11-19.
10.    Oyelowo OT, Raji Y, and Bolarinwa A.F. In-utero expos Phytochemical and Pharmacological Profile of Annona squamosa Linn: A Review to ripe Carica papaya seed resulted in postnatal outcomes from only first and second trimesters in rats. International Journal of Advanced Research. (2014) ; 2 (6): 254-266.
11.    Shubham  S.  Phytochemical Analysis of Papaya Leaf Extract: Screening Test.  EC Dental Science. 2019; 18.3: 485- 490
12.    Kaur M, Naveen CT, Sahrawat S, Kumar A, Stashenko EE. Ethnomedicinal uses, phytochemistry and pharmacology of Carica papaya plant: a compendious Review. Mini-Reviews in Organic Chemistry, 2019; 16 (5).
13.    Jhade D, Ahirwar D, Jain R, Sharma NK and Gupta S. A Pharmacological Review: Amaranthus spinosus. Research Journal of Pharmacognosy and Phytochemistry. 2009;1(3): 169-172.
14.    Wolf PL, Biochemical diagnosis of liver diseases. Indian Journal of Clinical Biochemistry. 1999; 14: 59–90
15.    Yogiraj V, Kumar GP , Singh CC, Goyal A, Vyas B. Carica papaya Linn: An Overview. IJHM. (2014); 2 (5): 01-08.
16.    Arvind G, Bhowmik, D, Duraivel S, and Harish G. Traditional and medicinal uses of Carica papaya. J Med Car Pap.2013; 1(1):2320-3862.
17.    Jyotsna KP, Kumar Y, Pandey P, and Masih H. Antibacterial Activity of Seed and Leaf Extract of Carica Papaya var. Pusa dwarf Linn. IOSR Journal of Pharmacy and Biological Sciences. 2014; 9(2): 29-37.
18.    Dwivedi, M.K., Sonter, S., Mishra, S. Antioxidant, antibacterial activity, and phytochemical characterization of Carica papaya flowers. Beni-Suef Univ J Basic Appl Sci 2020;9:23.
19.    Patel PM., Patel N., Goyal RK. Quality control of herbal products. The Indian Pharmacist. vol. (2006b); 5(45): 26- 30.
20.    Saravanan. J, Shariff W.R., .Joshi Narasimhachar. H, Varatharajan R., Joshi V.G., Karigar Asif A. Preliminary Pharmacognostical and Phytochemical Studies of Leaves of Hemigraphis colorata. Research Journal of Pharmacognosy and Phytochemistry. 2010; 2(1):, 15-17.
21.    Patil S, Zafar S, Bapat US, and Bhoir M. Standardization and Stability Study of Jawarish-e-Bisbasa, A Unani Formulation. Biological Forum An International Journal. 2011; 3(2): 14-17
22.    Evans WC, Treas and Evans. Pharmacognosy. 15 th edition, W.B. Saunders, Edinburgh London New York Philadelphia St Louis Sydney Toronto. 2002;520–542
23.    Dr. Kokate C K, Gokhale SB and Purohit, A P. Pharmacognosy. Nirali Prakashan.2008.
24.    Singh D, Rai AK, Maurya SP, Maurya A, Asthana A and Mauryaetal SM. Preliminary phytochemical screening of Carica papaya linn: seed. World Journal of Pharmacy and Pharmaceutical Sciences. 2018; 7: ( 10)1425-1439.
25.    Dr. Kokate CK, Gokhale SB, and Purohit AP. Pharmacognosy Nirali Prakashan. 2008; 49th ed: pp .14.23
26.    Mukherjee PK. Quality Control of Herbal Drugs, Business Horizon’s. Pharmaceutical Publishers New Delhi. 2002; pp. 138–141.
27.    Khandelwal KR. Practical Pharmacognosy Technique and experiments. Nirali Prakashan Delhi.2005; 19(1):pp.: 149-161.
28.    Harborne JB. Methods of extraction and isolation, Phytochemical Methods. Chapman & Hall, London.1998.pp. 60–66.
29.    Chase CR, and Pratt RJ (1949). Fluorescence of powdered vegetable drugs with particular reference to development of a system of identification. J. Am. Pharmacol. Assoc.1949. 38: 32–33.
30.    Harborne JB. Phytochemical Methods, Guide to Modern Techniques of Plant Analysis.3rd edition, Springer (India) Pvt. Ltd., New Delhi.1998;pp 5–12.
31.    Khandelwal KR. Practical Pharmacognosy, Technique and experiments, Nirali Prakashan Delhi, 2008.19(1)., 183.921.
32.    Stahl Egon. Thin layer chromatography, A Laboratory Handbook. Springer (India) Pvt, ltd.2000.
33.    Priyadarshi A, Ram BA. Review on pharmacognosy, phytochemistry and pharmacology activity of Carica papaya (LINN.) leaf. International Journal of Pharmaceutical Sciences and Research. 2018; 9(10):4071-4078
34.    Orhu PO and Momoh ARM. Antibacterial activity of different solvent extract of Carica papaya fruit parts on some gram positive and gram negative organisms, IJHPR.2013; 2(3):42-47.
35.    Nirosha N, and Mangalanayaki R. Antibacterial Activity of Leaves and Stem Extract of Carica papaya L., International Journal of Advances In Pharmacy, Biology And Chemistry. 2013;2(3): 2277 – 4688
36.    Aruljothi S, Uma C, Sivagurunathan P, Bhuvaneswari M. Investigation on Antibacterial Activity of Carica Papaya Leaf Extracts against Wound Infection-Causing Bacteria, International Journal of Research Studies in Biosciences.2014 2(11); 2349-0357
37.    Hariprasad PS, Ramakrishnan N.HPTLC fingerprint profile of Rumex vesicarius L. Asian J Pharm Clinical Research.2011; 4(2): 134-6.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available