Ali Arkan Majhool, Hamidah Idris, Wan Mohd Nuzul Hakimi, Muhd Danish Daniel Abdullah
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Ali Arkan Majhool1, Hamidah Idris1*, Wan Mohd Nuzul Hakimi2, Muhd Danish Daniel Abdullah3
1Department of Biology, Faculty of Science and Mathematics, Sultan Idris Education Universiti, 35900 UPSI, Tanjung Malim, Perak, Malaysia.
2Department of Chemistry, Faculty of Science and Mathematics, Sultan Idris Education University, 35900 UPSI, Tanjung Malim, Perak, Malaysia.
3Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia.
Volume - 14,
Issue - 9,
Year - 2021
The existing study examined three actinomycetes isolated from Beach Ridges Interspersed with Swales (BRIS) soil where the morphological properties were examined and chemical compounds of their metabolite extracts were ana; ysed. Based on phylogenetic analysis of 16S rRNA gene sequences, the strains were identified as Streptomyces sp. AA13, Amycolatopsis sp. AA12 and Micromonosporasp. AA141. Antimicrobial activities of the extracts were tested against a panel of microorganisms that consist of Escherichia coli DSM 30083, Bacillus subtilis DSM 10, Pseudomonas fluorescens DSM 50090, Klebsiella pneumoniae DSM 30104, Micrococcus luteus DSM 20030, and Saccharomyces cerevisiae. Results revealed a wide range of antimicrobial activities produced by the isolates at different concentration of each extracts. The extracts were found to show stronger antimicrobial activities against gram-negative bacteria compared to gram-positive bacteria, while no activities were shown when tested against fungi. Thirty-nine compounds were detected both from Streptomycessp. AA13 and Amycolatopsissp. AA12, while thirty-eight compounds from Micromonosporasp. AA141 using GC-MS. This Study Demonstrate the ability of actinomycetes in producing variety type of compounds with antimicrobial activities that may be the potential candidates as drug leads.
Cite this article:
Ali Arkan Majhool, Hamidah Idris, Wan Mohd Nuzul Hakimi, Muhd Danish Daniel Abdullah. Chemical Compounds and Antimicrobial Activities of Actinomycetes Isolates from BRIS Soil. Research Journal of Pharmacy and Technology. 2021; 14(9):4783-8. doi: 10.52711/0974-360X.2021.00832
Ali Arkan Majhool, Hamidah Idris, Wan Mohd Nuzul Hakimi, Muhd Danish Daniel Abdullah. Chemical Compounds and Antimicrobial Activities of Actinomycetes Isolates from BRIS Soil. Research Journal of Pharmacy and Technology. 2021; 14(9):4783-8. doi: 10.52711/0974-360X.2021.00832 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-9-46
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