Author(s): Prawati Nuraini, Mega Moeharyono Puteri, EksaArinda Pramesty


DOI: 10.52711/0974-360X.2021.00875   

Address: Prawati Nuraini1*, Mega Moeharyono Puteri1, EksaArinda Pramesty2
1Assistance Professor of Pediatric Dentistry Department, Faculty of Dentistry, Universitas Airlangga, Surabaya, Indonesia.
2Student Faculty of Dentistry, Universitas Airlangga, Surabaya, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021

Dental caries is a disease caused by Streptococcus mutans. The use of chlorhexidine to inhibit bacterial colonization has side effects such as tooth staining and can kill the normal flora when used long term. Epigallocatechin gallate (EGCG) is a chemical compound in the form of polyphenols from green tea catechins which have antimicrobial potency to inhibit microorganism growth and biofilm formation. Type Laboratory Experimental Research In-vitro. The group that will be studied are the negative control group in the form of S.mutans + 5% sucrose, the treatment group in the form of S. mutans + 5% sucrose and EGCG concentration of 0.125mg/ml, 0.25mg/ml, 0.375mg/ml and a positive control group is S.mutans + 5% sucrose and 0.1% chlorhexidine. Data were analyzed using the Kolmogorov-Smirnov test to determine the normality of the data, Levene's test for homogeneity of data, One Way ANOVA Post Hoc Tukey HSD Multiple Comparison to determine differences between treatments. Results: There were significant differences between the treatment groups and the negative control at test results Post Hoc Tukey HSD and the significant differences in the concentration of EGCG 0.375mg/ml with the positive control given chlorhexidine 0.1% (p <0.05). Epigallocatechin gallate (EGCG) influence on the activity of S. mutans biofilm formation and EGCG concentration of 0.375mg/ml are more effective as an antibiofilm of S. mutans compared with chlorhexidine 0.1%.

Cite this article:
Prawati Nuraini, Mega Moeharyono Puteri, EksaArinda Pramesty. Anti-biofilm Activity of Epigallocatechin gallate (EGCG) against Streptococcus mutans bacteria. Research Journal of Pharmacy and Technology. 2021; 14(9):5019-3. doi: 10.52711/0974-360X.2021.00875

Prawati Nuraini, Mega Moeharyono Puteri, EksaArinda Pramesty. Anti-biofilm Activity of Epigallocatechin gallate (EGCG) against Streptococcus mutans bacteria. Research Journal of Pharmacy and Technology. 2021; 14(9):5019-3. doi: 10.52711/0974-360X.2021.00875   Available on:

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