ABSTRACT:
Background: Holoptelea integrifolia has been used for a long time in traditional medicine to cure inflammatory pain. The goal of the current research was to consider the anti-inflammatory activity and phytochemicals study of both the extracts of the stem bark of Holoptelea integrifolia. Methods: Anti-inflammatory potential was figure out in Carrageenan and Histamine models at 200 mg/kg doses. Apart from this, we have evaluated parameters like paw edema body weight, locomotor activity, hematological, biochemical assessment, etc. Results: Qualitative chemical test investigation of both the extracts of H. integrifolia stem bark acknowledge the presence of proteins, amino acids, alkaloids, glycosides, tannins, and flavenoids. The 200 mg/kg, p.o dose of the extract showed remarked (P < 0.05) dose-dependent inhibition of edema formation. Both the ethanolic extract (200 mg/ kg, b. w) and aqueous extract (200 mg/ kg, b. w) of H. integrifolia stem bark showed remarked anti-inflammatory properties in comparison to reference drug Ibuprofen. In the Carrageenan model, the ethanolic extract has good anti-inflammatory activity than the aqueous extract. So, the ethanolic extract of stem bark of H. integrifolia is used to combat inflammation alone or with other conventional anti-inflammatory agents to treat different inflammatory disorders. Conclusion: Taken together, these results support the traditional use of Holoptelea integrifolia as a potent anti-inflammatory agent that may be proposed for the treatment of inflammatory pain.