Author(s): Kamma Keerthi Sai

Email(s): kamma.keerthi@gmail.com

DOI: 10.52711/0974-360X.2022.00004   

Address: Kamma Keerthi Sai
Assistant Professor, Department of Pharmaceutics, Aditya College of Pharmacy, Aditya Nagar, ADB Road, Surampalem, East Godavari District, A.P - 533437, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 1,     Year - 2022


ABSTRACT:
The aim of this present research work is to formulate and evaluate mouth dissoving films using Memantine hydrochloride as a model drug which is used for facilitating rapid onset of action in Alzheimer’s patients who are mentally ill. The films were designed to dissolve upon contact with a wet surface, such as tongue, within a few seconds especially for these patients who are unable to swallow. In this present research work various trials were carried out using different grades of HPMC E3, E5 and E15 by solvent casting method. The prepared films were eva1uated for morphological properties, weight variation, drug content uniformity, thickness uniformity, folding endurance, surface pH, In-vitro disintegration time,In-vitro dissolution studies and stability studies of the satisfactory formulation. Films prepared using HPMC E5 and E15 showed better morphohogical properties when compred with grade E3. Best formulations F4 and F8 prepared using HPMC E5 and E15 respectively with polymer concentration 45% showed minimum disintegration time and maximum dissolution rate. A slight increase in drug dissolution rate with F8 was observed but there is no significant difference between these two formulations was identified. These findings suggest that the fast dissolving film containing Memantine is considered to be potentially useful for the treatment of Alzheimer’s where geriatric patients feel difficulty to swallow a dosage form.


Cite this article:
Kamma Keerthi Sai. Formulation Development and In vitro Evaluation of Memantine Hydrochloride Fast Dissolving Oral Films employing different grades of Hydroxy Propyl Methyl Cellulose. Research Journal of Pharmacy and Technology. 2022; 15(1):17-3. doi: 10.52711/0974-360X.2022.00004

Cite(Electronic):
Kamma Keerthi Sai. Formulation Development and In vitro Evaluation of Memantine Hydrochloride Fast Dissolving Oral Films employing different grades of Hydroxy Propyl Methyl Cellulose. Research Journal of Pharmacy and Technology. 2022; 15(1):17-3. doi: 10.52711/0974-360X.2022.00004   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-1-4


REFERENCES:
1.    Dixit R, Puthli S. Oral strip technology:Overview and future potential. J. Control Release. 2009; 139: 94-107.
2.    Committee for medicinal and products for human use, European medicines agency EMEA, Reflection paper; formulation of choice of the pediatric population. 2006.
3.    Desu PK, Nama BBS, Nagalakshmi A. International journal of pharmaceutical research and Bio-Science. IJPRBS, 2013; 2(3): 298-305.
4.    Patel RA, Prajapat SD, Fast dissolving films as a newer venture in fast dissolving dosage forms. International Journal Drug Development and Research. 2010; 2(2): 232-246.
5.    Bhowmik Debjit, Chiranjib B, Krishnakanth, Pankaj, Margret R Chandira, Fast Dissolving Tablet: An Overview. Journal of Chemical and Pharmaceutical Research. 2009; 1(1): 163-177.  
6.    Rajni Bala, Pravin pawra, Sushil Khanna, Sandeep Arora.Orally dissolving strips: A new approach to oral drug delivery system, International Journal of Pharmaceutical Investigation. 2013; 3(2): 67-76
7.    Vondrak B, Barnhart S. Dissolvable Films for Flexible Product Format in Drug Delivery, Pharmaceutical    technoogy Supplement. April 2008.
8.    www.ijppr.humanjournals.com Citation: Ms. Prakruti M.Amin et al. IJPPR. Human, 2015; 3(3): 183-203.
9.    www.drugs.com.
10.    Shimoda H, Taniguchi K et al. Preparation of a fast dissolving oral thin film containing dexamethasone A possibe appjication to antiemesis during cancer chemotherapy. Eur J Pharm Biopharm. 2009; 73(3): 361-36

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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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