Author(s): Irma Erika Herawati, Jutti Levita, Ronny Lesmana, Anas Subarnas

Email(s): irmaerikaherawati@unfari.ac.id

DOI: 10.52711/0974-360X.2022.00067   

Address: Irma Erika Herawati1,2*, Jutti Levita1, Ronny Lesmana3,4, Anas Subarnas1
1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, West Java, Indonesia 45363.
2Department of Pharmacy, Universitas Al Ghifari, West Java, Indonesia 40293.
3Physiology Molecular Laboratory, Central Laboratory, Universitas Padjadjaran, West Java, Indonesia 45363.
4Department of Medical Basic Sciences, Faculty of Medicine, Universitas Padjadjaran, West Java, Indonesia 45363.
*Corresponding Author

Published In:   Volume - 15,      Issue - 1,     Year - 2022


ABSTRACT:
Ribosome-inactivating proteins (RIPs) are toxins that are capable to permanently inhibit the synthesis of protein. RIP type II is a heterodimeric protein consisting of an A subunit linked to a lectin-like B chain by a disulfide bridge. Ricin contained in the seeds of Ricinus communis L. is a type II RIP which possesses cytotoxicity activity. However, due to the non-selectivity of the B-lectin chain, ricin needs delivering-vehicles to enhance its cytotoxicity. This article is devoted to reviewing the anticancer activity of ricin in castor bean seeds (a plant type II RIPs) and its various types of cytotoxicity enhancers.


Cite this article:
Irma Erika Herawati, Jutti Levita, Ronny Lesmana, Anas Subarnas. Ricin in Castor Bean (Ricinus communis L.) Seeds: A Review on its Anticancer Activity and The Role of Cytotoxicity Enhancers. Research Journal of Pharmacy and Technology. 2022; 15(1):405-8. doi: 10.52711/0974-360X.2022.00067

Cite(Electronic):
Irma Erika Herawati, Jutti Levita, Ronny Lesmana, Anas Subarnas. Ricin in Castor Bean (Ricinus communis L.) Seeds: A Review on its Anticancer Activity and The Role of Cytotoxicity Enhancers. Research Journal of Pharmacy and Technology. 2022; 15(1):405-8. doi: 10.52711/0974-360X.2022.00067   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-1-67


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