Author(s): Satvir Singh, Divya. D. Bhandari, Monika Gupta, Jagdeep Singh

Email(s): divya.pharma@cumail.in

DOI: 10.52711/0974-360X.2022.00738   

Address: Satvir Singh1, Divya. D. Bhandari1, Monika Gupta2, Jagdeep Singh3
1University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali, Punjab, India.
2Department of Pharmaceutical Chemistry, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India.
3Indian Institute of Technology, Ropar, Punjab, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022


ABSTRACT:
A total of 18 derivatives S(1-18) of naphthoic acid linked Imidazo[2,1-b][1,3,4]thiadiazole were synthesized and tested for their anticancer potential at human cancer cell line A – 549. The interaction of the proposed derivatives with the colchicine binding domains of the receptor was also performed using Maestro 10.5 program (Schrodinger Inc. USA). Molecular docking study was performed for synthesized compounds displaying a significant inhibitory activity in order to validate their binding mode to active site. All the 18 inhibitors were docked into the active site of the receptor in two poses. The G-scores and binding energy for compound S4, S10, S12, S13 and S16 were observed to be comparable to the standard Colchicine. The compound S1, S5, S10, S12 and S16 exhibited prominent inhibition of cancer cell line.


Cite this article:
Satvir Singh, Divya. D. Bhandari, Monika Gupta, Jagdeep Singh. Design, Synthesis and Anticancer potential evaluation of Novel Naphthoic Acid linked Imidazo[2,1-b][1,3,4]thiadiazoles. Research Journal of Pharmacy and Technology2022; 15(10):4405-2 doi: 10.52711/0974-360X.2022.00738

Cite(Electronic):
Satvir Singh, Divya. D. Bhandari, Monika Gupta, Jagdeep Singh. Design, Synthesis and Anticancer potential evaluation of Novel Naphthoic Acid linked Imidazo[2,1-b][1,3,4]thiadiazoles. Research Journal of Pharmacy and Technology2022; 15(10):4405-2 doi: 10.52711/0974-360X.2022.00738   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-10-11


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