Author(s): Shailendra Singh Narwariya, Suman Jain


DOI: 10.52711/0974-360X.2022.00739   

Address: Shailendra Singh Narwariya, Suman Jain
School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022

Fenoprofen, a potent nonsteroidal anti-inflammatory drug, is widely used for relief of pain in patients suffering from rheumatic diseases, migraine, sore throat and primary dysmenorrheal. However, this drug has many gastrointestinal side effects produced by its oral administration, such as gastric bleeding and peptic ulcer. These effects were responsible for non-compliance among patients, which ultimately results in treatment failure. The physicochemical properties of Fenoprofen, make it a suitable candidate for transdermal drug delivery, which can overcome the drawbacks of oral administration. In this sense, tablets have been proved to increase the cutaneous absorption of lipophilic drugs when compared to conventional drug delivery systems. The carrageenan test is highly sensitive to nonsteroidal anti-inflammatory drugs and has long been accepted as a useful model to determine the anti-inflammatory effects of natural products. In the present study the anti-inflammatory activity of Fenoprofen and superdisintegrant was investigated by experimental carrageenan animal model. In our study, the induction of carrageenan in the rat hind paw started off the vascular phase of inflammation which was characterized by temporary vasoconstriction and vasodilatation that generated an increase in the size of the edema for all groups.

Cite this article:
Shailendra Singh Narwariya, Suman Jain. Physicochemical In vivo Anti-Inflammatory effect of Tablet containing Fenoprofen. Research Journal of Pharmacy and Technology2022; 15(10):4413-5. doi: 10.52711/0974-360X.2022.00739

Shailendra Singh Narwariya, Suman Jain. Physicochemical In vivo Anti-Inflammatory effect of Tablet containing Fenoprofen. Research Journal of Pharmacy and Technology2022; 15(10):4413-5. doi: 10.52711/0974-360X.2022.00739   Available on:

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