Author(s): Hany Akeel Al-Hussaniy, Zainab Noori Mohammed, Ali H. Alburghaif, Meena Akeel Naji

Email(s): hanyakeel2018@gmail.com

DOI: 10.52711/0974-360X.2022.00771   

Address: Hany Akeel Al-Hussaniy1*, Zainab Noori Mohammed2, Ali H. Alburghaif 3, Meena Akeel Naji4
1PhD Candidate at the Department of Pharmacology College of Medicine, Baghdad University, Iraq.
2Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Iraq.
3Department of Pharmacy, Ashur University Collage, Baghdad Iraq.
4Department of Family Medicine, Collage of Medicine, University of Baghdad, Iraq.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022


ABSTRACT:
Background; panax ginseng is one of the best ayurvedic plant used for treatment of several types of disease such as diabetes, improve the libido and hair-lose and as antioxidant also decrease the side effect and toxicity of several chemotherapy and toxic substances and several studies show that it may have an anticancer effect. Aim: to find out the effect of panax ginseng to decrease the cardiotoxicity the occur as a result of several chemotherapeutic medication such as doxorubicin and the effect of panax ginseng on cellular biomarker and cancer suppressor substance for evaluation of possible anticancer effect of panax ginseng. Methods: forty rate module has been enrolled in this study, divided into four groups ten rats for each groups, first group receive purified water, second groups receive Panax ginseng orally in 100mg/kg dose, third group receive panax ginseng with doxorubicin whereas the last groups receive high dose of panax ginseng only, blood sample also collected and organs such as heart is extracted, the serum level of several biomarker and cancer modulators has been evaluated. Results: Panax ginseng significantly reduce cardiotoxicity by its antioxidant mechanism, Panax ginseng reduced cardiac troponin (cTnI) However, its effect on reduction of BNP levels insignificantly compared to the doxorubicin group P=0.06. Panax ginseng reduced LPO and MDA and raised the antioxidant potential biomarker GSH significantly compared to the doxorubicin group P<0.05. Panax ginseng significantly reduced inflammatory (TNF-a) and apoptotic (caspase-3) biomarkers when compared to the doxorubicin group. Panax ginsing increase caspase level also and in addition, MDA, LPO, TNF-a, and caspase-3 levels were increased in doxorubicin group compared to the control group P<0.05. Conclusions: as a result of our research, Panax ginseng significantly show cardioprotective effect that it supresses the oxidative stress and other cardiotoxic parameters , However in high dose show to have anticancer by itself through caspase medullated apoptosis whereas the casepace 3 level significantly


Cite this article:
Hany Akeel Al-Hussaniy, Zainab Noori Mohammed, Ali H. Alburghaif , Meena Akeel Naji. Panax ginseng as Antioxidant and Anti-inflammatory to reduce the Cardiotoxicity of Doxorubicin on rat module. Research Journal of Pharmacy and Technology 2022; 15(10):4594-0. doi: 10.52711/0974-360X.2022.00771

Cite(Electronic):
Hany Akeel Al-Hussaniy, Zainab Noori Mohammed, Ali H. Alburghaif , Meena Akeel Naji. Panax ginseng as Antioxidant and Anti-inflammatory to reduce the Cardiotoxicity of Doxorubicin on rat module. Research Journal of Pharmacy and Technology 2022; 15(10):4594-0. doi: 10.52711/0974-360X.2022.00771   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-10-44


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