Author(s): Manish Devgun, Nandini, Lalit Singh, Saurabh Sharma

Email(s): manishdevgun@gmail.com

DOI: 10.52711/0974-360X.2022.00775   

Address: Manish Devgun1*, Nandini2, Lalit Singh3, Saurabh Sharma4
1Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana – 136119.
2Rajshree Medical Research Institute, Bareilly, Uttar Pradesh – 243501.
3Department of Pharmacy, Invertis University, Bareilly, Uttar Pradesh – 243123.
4Vivek College of Technical Education, Bijnor, Uttar Pradesh – 246701.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022


ABSTRACT:
PHF14 (PHD finger protein 14) is associated with Plant Homeodomain (PHD) Finger Protein family. This chromatin-binding protein interacts with histones. PHF14 overexpression has gained attention due to compelling evidence of its involvement in cell proliferation of various cell lines. PHF14 plays a critical function in the induction of pulmonary fibrosis, and actively participate in cell mitosis which makes it a probable target in the treatment of lung fibrosis and can also be utilized as a biomarker in evaluation and management of non small cell lung cancer. A model of PHF14 protein was prepared by homology modelling and was verified by Ramachandran plot. This model of PHF14 protein was acknowledged by Protein Model Data Base (PMDB) and has been assigned PMDB ID: PM0084114. The DrugBank database was used to obtain ligands, to dock against PHF14 by applying PatchDock technique. The structure of the selected ligand (DB08438) was then modified by means of ACD/ChemSketch 8.0 to secure 22 new in silico ligands, which were subjected to the docking procedure. The docking results identify ligand 31 to possess a high binding affinity with the target protein. The in silico docking results suggests that ligands 31, 12, 13, 14, 15, 16, 18, 19, 20, 21, 22, 23, 26, 29, 30, 31, 32, and 33 have a high preference for binding with PHF14 and these compounds should be thoroughly probed so as to develop potential chemical entities for the suppression of malignant transformation and tumorigenicity of non small cell lung cancer.


Cite this article:
Manish Devgun, Nandini, Lalit Singh, Saurabh Sharma. Structure Prediction and In-silico Designing of Drugs against Plant Homeodomain Finger Protein 14 for Suppression of Malignant Transformation and Tumorigenicity of Non Small Cell Lung Cancer. Research Journal of Pharmacy and Technology 2022; 15(10):4621-6. doi: 10.52711/0974-360X.2022.00775

Cite(Electronic):
Manish Devgun, Nandini, Lalit Singh, Saurabh Sharma. Structure Prediction and In-silico Designing of Drugs against Plant Homeodomain Finger Protein 14 for Suppression of Malignant Transformation and Tumorigenicity of Non Small Cell Lung Cancer. Research Journal of Pharmacy and Technology 2022; 15(10):4621-6. doi: 10.52711/0974-360X.2022.00775   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-10-48


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