Author(s):
Asha A, MLV Prabhuji, Rashmi P, Roja Y, Shaeesta Khaleelahmed Bhavikatti
Email(s):
ashabyahatti1992@gmail.com , prabhujimlv@gmail.com , rashparams2005@yahoo.co.in , drshaeesta@gmail.com , rojaroyal246@gmail.com
DOI:
10.52711/0974-360X.2022.00732 
Address:
Asha A1, MLV Prabhuji2, Rashmi P3, Roja Y4, Shaeesta Khaleelahmed Bhavikatti5
1Post Graduate Student, Department of Periodontology, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru - 562157 Karnataka, India.
2Head of The Department, Department of Periodontology, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru - 562157 Karnataka, India.
3Reader, Department of Periodontology, Krishnadevaraya College of Dental Sciences and Hospital,
Bengaluru - 562157 Karnataka, India.
4Post Graduate Student, Department of Periodontology, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru - 562157 Karnataka, India.
5Department of Periodontics, PhD Research Scholar, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Malaysia.
*Corresponding Author
Published In:
Volume - 15,
Issue - 10,
Year - 2022
ABSTRACT:
Introduction: Oxygen is a prerequisite for successful wound healing due to the increased demand for reparative processes such as cell proliferation, bacterial defense, angiogenesis and collagen synthesis. Even though the role of oxygen in wound healing is not fully ascertained many experimental investigations and clinical observations have shown wound healing to be impaired under hypoxia. Since the periodontal pocket harbours anaerobic microorganisms a high concentrated oxygen formulation could prove to be a lethal elimination tool. Objective: The main objective of this study was to evaluate efficacy of high concentrated oxygen oral gel on the reduction of periodontal pocket. Materials and methods: A female patient of age 28 years without any systemic complication or allergic reaction reporting to Outpatient department of Krishnadevaraya College of Dental Sciences was examined. After ascertaining the presence of periodontal pocket (= 5mm) without infrabony defects, she was enlisted for the study. Following scaling and root planing and oral hygiene reinforcement, daily application of (Blue®M) TM oral gel for 7 days into the pocket was carried out, re-evaluation of the pocket depth was done after 30 days. Conclusion: High concentrated oxygen (Blue®M)TM oral gel could be locally delivering drug in reduction of periodontal pocket.
Cite this article:
Asha A, MLV Prabhuji, Rashmi P, Roja Y, Shaeesta Khaleelahmed Bhavikatti. Pocket reduction with High Concentrated oxygen oral gel: A Preliminary Case Report. Research Journal of Pharmacy and Technology2022; 15(10):4367-1. doi: 10.52711/0974-360X.2022.00732
Cite(Electronic):
Asha A, MLV Prabhuji, Rashmi P, Roja Y, Shaeesta Khaleelahmed Bhavikatti. Pocket reduction with High Concentrated oxygen oral gel: A Preliminary Case Report. Research Journal of Pharmacy and Technology2022; 15(10):4367-1. doi: 10.52711/0974-360X.2022.00732 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-10-5
REFERENCES:
1. Dosseva-Panova VT, Popova CL, Panov VE. Subgingival microbial profile and production of proinflammatory cytokines in chronic periodontitis. Folia Med (Plovdiv). 2014, 56 (3):152-60. DOI: 10.2478/folmed-2014-0022
2. Ravishankar PL, Kumar YP, Anila EN, Chakraborty P, Malakar M, Mahalakshmi R. Effect of local application of curcumin and ornidazole gel in chronic periodontitis patients. Int J Pharm Investig. 2017, 7(4):188-192. DOI: 10.1902/jop.2000.71.1.125
3. Carmello JC, de Annunzio SR, Fontana CR. Composition, Structure, and Formation of Biofilms Constituted by Periodontopathogenic Microorganisms. In Bacterial Biofilms 2020 Oct 7. IntechOpen. DOI: 10.5772/intechopen.90019
4. Kalsi R, Vandana KL, Prakash S. Effect of local drug delivery in chronic periodontitis patients: A meta-analysis. J Indian Soc Periodontol. 2011, 15(4):304-9. doi: 10.4103/0972-124X.92559. doi: 10.4103/0972-124X.92559
5. Perinetti G, Paolantonio M, Cordella C, D'ercole S, Serra E, Piccolomini R. Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients. Journal of clinical periodontology. 2004, 31(4):282-5 https://doi.org/10.1111/j.1600-051x.2004.00481.x
6. Knoll-Köhler E. Metronidazole dental gel as an alternative to scaling and root planing in the treatment of localized adult periodontitis. Is its efficacy proved? Eur J Oral Sci. 1999, 107(6):415-21 DOI: 10.1046/j.0909-8836.1999.eos107601.x
7. Vinholis AH, Figueiredo LC, Marcantonio Júnior E, Marcantonio RA, Salvador SL, Goissis G. Subgingival utilization of a 1% chlorhexidine collagen gel for the treatment of periodontal pockets. A clinical and microbiological study. Braz Dent J. 2001;12(3):209-13.
8. Goodson JM, Haffajee A, Socransky SS. Periodontal therapy by local delivery of tetracycline. Journal of Clinical Periodontology. 1979, 6(2):83-92. https://doi.org/10.1111/j.1600-051X.1979.tb02186.x
9. Goodson JM, Hogan PE, Dunham SL. Clinical responses following periodontal treatment by local drug delivery. Journal of periodontology. 1985 Nov;56 :81-7. https://doi.org/10.1902/jop.1985.56.11s.81
10. Greenstein G, Tonetti M. The role of controlled drug delivery for periodontitis. The Research, Science and Therapy Committee of the American Academy of Periodontology. Journal of periodontology. 2000, 71(1):125-40. DOI: 10.1902/jop.2000.71.1.125
11. Amitha ramesh, Agumbe priyanka prakash, Biju thomas - Local drug delivery in periodontal diseases - Nitte university journal of health science (march 2016). DOI: 10.1055/s-0040-1708622
12. Ankur singh rajpoot, Anuj singh parihar - Local drug delivery in periodontics - International journal of research in health and allied science (july - august 2017).
13. Dharshan Mundinamane, Sucheta A, Karthik venkataraghavan, Akanksha Garg- Newer trends in local drug delivery for periodontal problems- a preview- aug(2011)
14. Slots J, Rams TE. Local delivery of antimicrobial agents in the periodontal pocket (2000) https://doi.org/10.1111/j.1600-0757.1996.tb00072.x
15. Knighton, D.R., Hunt, T.K., Scheuenstuhl, H., Halliday, B.J., Werb, Z. and Banda, M.J. (1983) Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages. Science, 221, 1283-1285. DOI: 10.1126/science.6612342
16. Waddington RJ, Moseley R,Embery G. Periodontal Disease Mechanisms: Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases. Oral diseases;2000, 6(3):138-51. https://doi.org/10.1111/j.1601-0825.2000.tb00325.x
17. Piruat JI, López-Barneo J. Oxygen tension regulates mitochondrial DNA-encoded complex I gene expression. Journal of Biological Chemistry. 2005;280: 42676–42684. https://doi.org/10.1074/jbc.M507044200
18. Deliberador TM, Weiss SG, Rychuv F, Cordeiro G, Ten Cate MC, Leonardi L, Brancher JA, Scariot R. Comparative analysis in vitro of the application of blue® m oral gel versus chlorhexidine on Porphyromonas gingivalis: A pilot study. Advances in Microbiology.2020, 10(04):194 DOI: 10.4236/aim.2020.104015
19. Semba H, Takeda N, Isagawa T, et al. HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun. 2016;7: 11635. DOIhttps://doi.org/10.1038/ncomms11635
20. Semenza GL. Oxygen sensing, hypoxiainducible factors, and disease pathophysiology. Annu Rev Pathol. 2014; 9:47–71.: 10.1146/annurev-pathol-012513-104720
21. Gölz L, Memmert S, Rath-Deschner B, et al. LPS from P. gingivalis and hypoxia increases oxidative stress in periodontal ligament fibroblasts and contributes to periodontitis. Mediators of Inflammation. 2014; 2014:1–13. https://doi.org/10.1155/2014/986264
22. Rodriguez PG, Felix FN, Woodley DT, et al. The role of oxygen in wound healing: A review of the literature. Dermatologic Surgery. 2008;34:1159–1169 https://doi.org/10.1111/j.1524-4725.2008.34254.x
23. Kalliainen LK, Gordillo GM, Schlanger R, et al. Topical oxygen as an adjunct to wound healing: A clinical case series. Pathophysiology. 2003;9:81–87. https://doi.org/10.1016/S0928-4680(02)00079-2
24. Oxygen therapy for treating acute necrotizing periodontal disease in smokers. J Periodontol. 2006;77:31–38. https://doi.org/10.1902/jop.2006.77.1.31
25. Mattei BM, Imanishi SA, de Oliveira Ramos G, de Campos PS, Weiss SG, Deliberador TM. Mouthwash with Active Oxygen (blue® m) Reduces Postoperative Inflammation and Pain. Case Reports in Dentistry. 2021, https://doi.org/10.1155/2021/5535807
26. Vaishali Priyadarshini, Priya Lochana Gajendran, Suresh Venugopalan, Thiyaneswaran Nesappan, Abinav Rajendra Prabhu. Comparing The Efficacy Of Two Oral Therapeutic Gels On Soft Tissue Healing Following Dental Implant Placement – Pilot Study. IJPR, 9[3] 2017
27. Niveda R, Kaarthikeyan G. Effect of Oxygen Releasing Oral Gel Compared to Chlorhexidine Gel in the Treatment of Periodontitis. Journal of Pharmaceutical Research International. 2020, 26:75-82. DOI: 10.9734/JPRI/2020/v32i1930711