Author(s): Anshika Choudhary, Md. Semimul Akhtar

Email(s): anshikachoudhary50@gmail.com , akhtar.mpharm@gmail.com

DOI: 10.52711/0974-360X.2022.00812   

Address: Anshika Choudhary*, Md. Semimul Akhtar
Shri Ram Murti Smarak College of Engineering and Technology, (Pharmacy), Bareilly 243202, Uttar Pradesh, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022


ABSTRACT:
A number of advancements have been made in the drug delivery system in order to achieve the goals of improved efficacy and cost-effectiveness in therapy. Controlling the rate of release of active drugs to a predetermined site in the human body has been one of the pharma industry's most challenging tasks. Microsponges are porous cross-linked, non-collapsible microspheres with a size range of 5-300µm that can entrap a variety of drugs and then be incorporated into a formulated product like gel, cream, powder, or liquid. Controlled release of drugs onto the epidermis with the confidence that the drug remains primarily localized and does not enter the systemic circulation in substantial amounts is a field of research that the microsponge delivery system is progressively exploring. In order to remove systemic exposure and minimize local cutaneous reaction to active drugs, microsponge technology has been introduced in topical drug products to facilitate the controlled release of the active drugs into the cell. Also, numerous studies have shown that microsponge systems are non-irritating, non-mutagenic, non-allergenic, and non-toxic. MDDS technology is being used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens, and prescription products and has recently been used in oral drugs as well as biopharmaceuticals (protein, peptides, and DNA based therapeutics) drug delivery. The purpose of this article is to provide information about microsponges such as the method of preparation, mechanism of drug release from microsponges, characterization, applications of microsponges, and information about microsponges updated research.


Cite this article:
Anshika Choudhary, Md. Semimul Akhtar. Microsponge Drug Delivery System: Emerging Technique in Novel Drug Delivery System and Recent Advances. Research Journal of Pharmacy and Technology 2022; 15(10):4835-0. doi: 10.52711/0974-360X.2022.00812

Cite(Electronic):
Anshika Choudhary, Md. Semimul Akhtar. Microsponge Drug Delivery System: Emerging Technique in Novel Drug Delivery System and Recent Advances. Research Journal of Pharmacy and Technology 2022; 15(10):4835-0. doi: 10.52711/0974-360X.2022.00812   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-10-85


REFERENCES:
1.    Shinkar D.M, Bhamare B.S, Saudagar R.B, Microsponges, Asian J. Res. Pharm. Sci. 2016;6(2):77-84. doi: 10.5958/2231-5659.2016.00011.4.
2.    Terse P, Mallya R, Formulation and Evaluation of Celecoxib loaded colon Targeted Microsponges, Asian J. Res. Pharm. Sci. 2020; 10(2):73-78. doi: 10.5958/2231-5659.2020.00014.4.
3.    Jangde R,Microsponges for colon targeted drug delivery system: An overview, Microsponges for colon targeted drug delivery system: An overview, Asian J. Pharm. Tech. 1(4): Oct. - Dec. 2011; Page 87-93.
4.    Pathak G.K, Chopra H, Sharma G.K, Formulation, development and evaluation of bioadhesive floating Microsponges of Domperidone, Research J. Pharm. and Tech. 2020; 13(1): 383-390. doi: 10.5958/0974-360X.2020.00076.1
5.    Shaha V, et al. Microsponge drug delivery: A review, International Journal of Research in Pharmaceutical Sciences, 2010 April; 1(2): 212-218.
6.    Bhatt P, et al. Oral Controlled Release Systems: Current Strategies and Challenges. In: Misra A, Shahiwala A, editors. Novel Drug Delivery Technologies: Innovative Strategies for Drug Repositioning. Singapore: Springer Singapore; 2019. p. 73-120. doi: 10.1007/978-981-13-3642-3_4.
7.    Mali A.D, Bathe R, An Updated Review on Formulation and Evaluation of Microsponge. Research J. Topical and Cosmetic Sci. 6(2): July-Dec. 2015 page 77-85. doi: 10.5958/2321-5844.2015.00011.4
8.    Umamaheswari R, Kothai S, Effectiveness of Copper nanoparticles loaded microsponges on Drug release study, Cytotoxicity and Wound healing activity, Research J. Pharm. and Tech 2020; 13(9):4357-4360. doi: 10.5958/0974-360X.2020.00770.2
9.    Aloorkar N, et al. Microsponges as innovative drug delivery systems. Int J Pharm Sci Nanotechnolgy, 2012 May, 5(1): 1597-1606.https://doi.org/10.37285/ijpsn.2012.5.1.2
10.    Verma P, Dhynai A and Juyal D: A brief review on microsponge use in chronopharmacology, The Pharmaceutical Innovation Journal 2018, 7(6): 538-543.
11.    Jyoti, Kumar S Innovative and novel strategy: Microsponge for topical drug delivery, Journal of Drug Delivery and Therapeutics 2018 Sept; 8(5): 28-34.doi: https://doi.org/10.22270/jddt.v8i5.1885
12.    Jagtap SC, Karale AA: Microsponge a novel topical drug delivery system, Journal of Drug Delivery Research 2014; 3(4).
13.    Tile MK and Pawar A: Microspong: A novel strategy for drug delivery, International Journal of Pure and Applied Bioscience 2015 Feb; 3(1): 224-235.
14.    Gupta NB, Sumbria R and Kumar K: Microsponges: topical preparations and its applications, World Journal of Pharmacy and Pharmaceutical Sciences 2017; 6(4): 629- 42. doi: 10.20959/WJPPS20174-8923.
15.    Kumari P, Mishra SK: A comprehensive review on novel microsponge drug delivery approach, Asian Journal of Pharmaceutical and Clinical Research 2016 May; 9(1).
16.    Makwana R, Patel H and Patel V: Microsponge for drug delivery system, International Journal of Pharmacy and Technology 2014; 5(4): 2839-51.
17.    Kapoor D, et al.A review on microsponge drug delivery system, Journal of Drug Delivery and Therapeutics, 2014 Sept; 4(5): 29-35.doi:https://doi.org/10.22270/jddt.v4i5.978
18.    Pathan HK, Saraf A, Dasani A. Microsponge drug delivery system as an innovation in cosmetic world: a review, Asian Journal of Pharmaceutical Education and Research, 2012; 1(2):67- 87.
19.    Joshi G, Kaur R, Kaur H, Microsponges: a novel drug delivery system, International Research Journal of Pharmaceutical and Biosciences, 2016 Jan; 3(1):01-11.
20.    Balamurugan K, Kshirsagar N, Govardhan P, Microsponges: as a drug delivery system, Pharma Innovation Journal, 2019; 8(1):139-143.
21.    Charde MS, et.al., Microsponge a novel new drug delivery system: a review, International Journal of Advances in Pharmaceutics, 2013 Dec; 2(6):63-70. doi: https://doi.org/10.7439/ijap.v2i6.1412
22.    Mishra SK, Kumari P, A comprehensive review on novel microsponge drug delivery approach, Asian Journal of Pharmaceutical and Clinical Research, 2016 Aug; 9(1):25-30.
23.    Gandhi KJ, Deshmane SV, Biyani KR, Polymers in pharmaceutical drug delivery system: a review, International Journal of Pharmaceutical Sciences Review and Research, 2012 May; 14(2):57-66.
24.    Osmani RA, et al., A new cornucopia in topical drug delivery: microsponge technology, Asian Journal of Pharmaceutical Science and Technology, 2014; 4(1):48-60.
25.    Ravi R, Senthilkumar SK, Parthiban S, Microsponges drug delivery system: a review, International Journal of Pharmacy Review and Research, 2013; 3(1):6-11.
26.    Patil SS, et al. Microsponge drug delivery system: an overview, European Journal of Pharmaceutical and Medical Research, 2016; 3(8):212-221.
27.    Nawal A, Mohammad S: Formulation and in-vitro evaluation of piroxicam microsponge as a tablet. International Journal of Pharmacy and Pharmaceutical Sciences, 2016 Feb; 8(2): 104-112.
28.    Shukla A, Garg A and Garg S: Application of microsponge technique in drug delivery system. Asian Journal of Biomaterial Research 2016; 2(4): 120-26.
29.    Mohit PB and Khanage SG: Recent advance in microsponge drug delivery system. Journal of Critical Review 2016 Jan; 3(1): 9-16.
30.    Thakur R, Kumar S, Gaba P, A review: novel method for microsponge drug delivery system, Journal of Pharmacy and Biological Sciences, 2020 Aug; 15(4):35-44.
31.    Upadhye SS,et al. A review on microsponge drug delivery system, International Journal of Pharmaceutical Research and Bioscience, 2016; 5(1):152-166.
32.    Ahire PV, Darekar AB, Saudagar RB, Review on microsponges as a novel drug delivery system, International Journal of Current Pharmaceutical Review and Research, 2017; 8(3):293-297.
33.    Mahajan AG,et al. Formulation and evaluation of microsponge drug delivery system using indomethacin, International Research Journal of Pharmacy, 2011 Oct; 2(10):64-69.
34.    Patel EK, Oswal RJ, Nanosponge and Microsponges: a novel drug delivery system, International Journal of Research in Pharmacy and chemistry, 2012; 2(2):237-244
35.    Shahzad Y, et al. Influence of polymer ratio and surfactants on controlled drug release from cellulosic microsponges, International Journal of Biological Macromolecules, 2018 Nov; 109:963-970. doi: 10.1016/j.ijbiomac.2017.11.089.
36.    Singhvi G, et al. Microsponge: an emerging drug delivery strategy, Drug Development and Research, 2018 Nov; 79:1-9.  https://doi.org/10.1002/ddr.21492.    
37.    Choudhary U.M, et al., Formulation and Development of Aceclofenac loaded Microsponges Topical Drug Delivery System using quality by Design Approach, Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(3):185-2. doi: 10.52711/0975-4377.2021.00033.
38.    Jadhav N, et al., Microsponge delivery system: an updated review, current status and future prospects, Journal of Scientific and Innovative Research, 2013 Jan; 2(6):1097-1110.
39.    D’souza J.I, More H.N, Study on Factors Influencing Drug Release from Fluconazole-Microsponges Prepared by Suspension Polymerization, Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 235-239.
40.    D’souza J.I, More H.N, Topical Anti-Inflammatory Gels of Fluocinolone Acetonide Entrapped in Eudragit Based Microsponge Delivery System. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 502-506.
41.    Sansare V, Microsponges: a novel drug delivery system. Paripex- Indian Journal of Research, 2019 Sept; 8(9):102-104.
42.    Kaity S, et al., Microsponges: a novel strategy for drug delivery system, Journal of Advanced Pharmaceutical Technology and Research, 2010 Sept; 1(3): 283-290.doi:10.4103/0110-5558.72416.
43.    Bhimavarapu R.,et al., Microsponges as a Novel Imperative for Drug Delivery System, Research J. Pharm. and Tech. 2013 Aug; 6(8).
44.    Garud ST, Tiwari K, Microsponges: a novel approach, Asian Journal of Pharmaceutical Science and Technology, 2018 Jan; 8(1):1-9.doi: https://doi.org/10.22270/jddt.v11i1.4492.
45.    Valluru R, et al., Microsponges- a comprehensive review: success and challenges, Indo American Journal of Pharmaceutical Research, 2019 Sept; 9(7):3056-3067.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available