Author(s): Norisca Aliza Putriana, Taofik Rusdiana, Tina Rostinawati, Mohammad Rizki Akbar

Email(s): t.rusdiana@unpad.ac.id

DOI: 10.52711/0974-360X.2022.00815   

Address: Norisca Aliza Putriana1, Taofik Rusdiana1*, Tina Rostinawati2, Mohammad Rizki Akbar3
1Department of Pharmaceutical and Formulation Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jalan Raya Bandung-Sumedang KM 21, Jatinangor 45363, Indonesia. 2Department of Biology Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jalan Raya Bandung-Sumedang KM 21, Jatinangor 45363, Indonesia.
3Department of Cardiovascular, Faculty of Medicine, Universitas Padjadjaran, Jalan Raya Bandung-Sumedang KM 21, Jatinangor 45363, Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022


ABSTRACT:
Warfarin is a type of vitamin K antagonist anticoagulant used to thromboembolic prevention and its maintenance dose differs significantly among patients. Moreover, the factor influencing the dose calculation is known as genetic polymorphism, while the influence of vitamin K intake while the effect of vitamin K intake is still a matter of debate. This study aims to provide an overview of several studies on the effect of vitamin K intake on the stability of the PT-INR value and anticoagulation in warfarin therapy patients. A study was conducted on the effect of vitamin K intake on the PT-INR value stability and anticoagulation in warfarin therapy patients. One study showed that there was no significant correlation between vitamin K usual intake and the anticoagulant effect, while in another, it was found that the stability of this effect is achievable with adequate amounts of the vitamin intake. Furthermore, another study showed that the anticoagulant effect is more stable in patients with excessive vitamin K intake on long-term warfarin use. However, other study showed that INR values will stabilize if vitamin K intake is relatively low. The results from various studies were different, therefore, there is a debate regarding the influence of vitamin K intake on the PT-INR value and anticoagulation.


Cite this article:
Norisca Aliza Putriana, Taofik Rusdiana, Tina Rostinawati, Mohammad Rizki Akbar. Influence of Vitamin K intake on INR and Anticoagulation in outpatients taking Warfarin. Research Journal of Pharmacy and Technology 2022; 15(10):4851-6. doi: 10.52711/0974-360X.2022.00815

Cite(Electronic):
Norisca Aliza Putriana, Taofik Rusdiana, Tina Rostinawati, Mohammad Rizki Akbar. Influence of Vitamin K intake on INR and Anticoagulation in outpatients taking Warfarin. Research Journal of Pharmacy and Technology 2022; 15(10):4851-6. doi: 10.52711/0974-360X.2022.00815   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-10-88


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