Author(s): Sonam Shukla, Swarnakshi Upadhyay, Rajneesh Kumar Gupta

Email(s): sonamkitpmph21@gmail.com

DOI: Solid dispersion, Griseofulvin, Gel, Melting method, Franz diffusion cell, Solubility.   

Address: Sonam Shukla*, Swarnakshi Upadhyay, Rajneesh Kumar Gupta
Kanpur Institute of Technology, Kanpur, Uttar Pradesh, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022


ABSTRACT:
In the present investigation, griseofulvin loaded solid dispersion were formulated using mannitol and PVP K30 as the hydrophilic carriers. The best formulation was then loaded in to gel formulation prepared either from carbopol 934P or HPMC. Melting method was adopted to prepare the solid dispersions of griseofulvin. The drug content was found to be highest in the formulation SD6 (94.60±0.7%) and the lowest in formulation SD1 (91.56 ±0.251%). A minimum of 10 fold increase in solubility was witnessed after formulating griseofulvin as SD. The minimum solubility was exhibited by SD1 (0.57±0.04mg/mL) whereas SD6 exhibited the highest solubility (2.09±0.080 mg/mL). SD6 released 47.16±1.167% after 15 min and around 80% drug released at 30 min. Hence SD6 was used for further formulation as gel. The pH value of all gel formulations lies within the 5.29 to 6.81 and they were homogeneous and uniform. The viscosity of the formulations ranged from 491±31 cp to 668±57.5 cp. The maximum amount of drug was released from formulation SDG2 (72.37%) followed by SDG4 (64.91%) by the end of 6th hour of the study. The formulation containing 1.0% of carbopol 934 was the gelling agent was considered to be the best formulation of all the prepared gels.


Cite this article:
Sonam Shukla, Swarnakshi Upadhyay, Rajneesh Kumar Gupta. Formulation and Evaluation of Griseofulvin Solid Dispersion incorporated gel for topical application. Research Journal of Pharmacy and Technology2022; 15(10):4389-4. doi: Solid dispersion, Griseofulvin, Gel, Melting method, Franz diffusion cell, Solubility.

Cite(Electronic):
Sonam Shukla, Swarnakshi Upadhyay, Rajneesh Kumar Gupta. Formulation and Evaluation of Griseofulvin Solid Dispersion incorporated gel for topical application. Research Journal of Pharmacy and Technology2022; 15(10):4389-4. doi: Solid dispersion, Griseofulvin, Gel, Melting method, Franz diffusion cell, Solubility.   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-10-9


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