Author(s):
SM Abdul Aziz Barbhuiya, Ajay Kakati, Muslek Uddin Mazumder, Md Rejwan Ahmed Choudhury, Mosrur Ahmed Laskar
Email(s):
smazizbarbhuiya53@gmail.com
DOI:
10.52711/0974-360X.2022.00851 
Address:
SM Abdul Aziz Barbhuiya1*, Ajay Kakati2, Muslek Uddin Mazumder1, Md Rejwan Ahmed Choudhury3, Mosrur Ahmed Laskar1
1University of Science and Technology, Ri-Bhoi, Meghalaya – 793101.
1NETES Institute of Pharmaceutical Science, Mirza, 781125, Assam, India.
2College of Veterinary Sciences, AAU, Khanapara, Guwahati, India.
3Assam Downtown University, Panikhati, Guwahati, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 11,
Year - 2022
ABSTRACT:
Aim: The current research was planned to explore the diverse pharmacognostic standards of unexplored traditionally used medicinal plants from Northeast India (Alpinia galanga, Chenopodium album, Mikania micrantha, Allium hookeri, & Eryngium foetidium). Materials and Methods: Leaves samples were collected, authenticated, elaborative studies by macroscopic, microscopic, and physicochemical characterization (As per WHO-recommended methods of standardization), and methanolic extracts were prepared. The anti-oxidant and anti-inflammatory action of the leaves extracts were also resolute by the DPPH assay with butylated hydroxyl anisole as benchmark and inhibition of protein denaturation method taking diclofenac sodium as a standard drug respectively. Results: The pharmacognostic and physicochemical parameters enable to evaluate purity and avoid adulteration of the crude drugs. Methanolic extract of Eryngium foetidium(MMEF) showed better antioxidant activity and methanolic extract of Alpinia galangal(MMAG) showed profound anti-inflammatory activity amongst all extracts. Conclusion: This study showed preliminary pharmacognostic standards for traditionally used medicinal plants and therapeutic information which would be good tools for future experimental biological activity study, together with the need for drug discovery and development.
Cite this article:
SM Abdul Aziz Barbhuiya, Ajay Kakati, Muslek Uddin Mazumder, Md Rejwan Ahmed Choudhury, Mosrur Ahmed Laskar. The pharmacognostic profiling of traditionally used medicinal plants of Northeast India and evaluation of their in-vitro anti-oxidant and anti- inflammatory potential. Research Journal of Pharmacy and Technology. 2022; 15(11):5062-7. doi: 10.52711/0974-360X.2022.00851
Cite(Electronic):
SM Abdul Aziz Barbhuiya, Ajay Kakati, Muslek Uddin Mazumder, Md Rejwan Ahmed Choudhury, Mosrur Ahmed Laskar. The pharmacognostic profiling of traditionally used medicinal plants of Northeast India and evaluation of their in-vitro anti-oxidant and anti- inflammatory potential. Research Journal of Pharmacy and Technology. 2022; 15(11):5062-7. doi: 10.52711/0974-360X.2022.00851 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-11-36
REFERENCES:
1. Saha D. Paul S. Pharmacognostic Studies of Aerial Part of Methanolic Extract of Alpinia conchigera Griff. Asian Journal of Pharmaceutical Analysis. 2012; 2(2):46-48.
2. Balaji VE. Selvan. TA. Srinivasan. A. Nandhini. S. Punica granatum root (s): Phytocompounds analysis, Anti-oxidant and Anti-microbial activity. Asian Journal of Pharmaceutical Analysis. 2019; 9(3):123-127. DOI: 10.5958/2231-5675.2019.00023.1
3. Saha D. Paul S. Pharmacognostic Studies of Aerial Part of Methanolic Extract of Vernonia patula. Asian Journal of Pharmaceutical Research. 2012; 2(3): 94-96.
4. Saha D. Paul S. Pharmacognostic Studies of Aerial Part of Methanolic Extract of Plumbago indica L. Asian Journal of Research in Pharmaceutical Sciences. 2012; 2(3): 88-90.
5. Saha D. Paul S. Pharmacognostic Studies of Aerial Part of Methanolic Extract of Tridax procumbens. Asian Journal of Pharmacy and Technology. 2012 2(3): 107-109.
6. Patel DS. Shah PB. Managoli N. B. Evaluation of In-vitro Anti-oxidant and Free Radical Scavenging activities of Withania somnifera and Aloe vera. Asian Journal of Pharmacy and Technology. 2012 2(4): 143-147.
7. Shankar R. Rawat MS. Conservation and cultivation of threatened and high valued medicinal plants in North East India. International Journal of Biodiversity and Conservation. 2013;5:584-591.
8. Lalzarzovi ST. Lalramnghinglova H. Traditional use of medicinal plants found within Aizawl city in Mizoram, India. Pleione. 2016;10:269 - 277. DOI: 10.5897/IJBC12.113
9. Athokpam R. Bawari M, Choudhury MD. A review on medicinal plants of manipur with special reference to hepatoprotection. International Journal of Advances in Pharmaceutical Research. 2014;5:182 – 191.
10. Vanwyk BE. Wink M. Medicinal Plant of the World. Briz Publication, South Africa. Edition I. 2009;7:43.
11. “Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines”, World Health
1. Organization, Regional office for the Western Pacific, Manila. 1993:1-2.
12. Rajpal VB. Kohli DPS. Herbal Drug Industry. Business Horizons, New Delhi. Edition II. 2009: 100- 101.
13. Kirtikar KR. Basu BD. Indian Medicinal Plants. International Book Distributors, Dehradun (Uttranchal). Edition IV: 2444-2447.
14. Ram P. Rastogi, BN. Malhotra. Compendium of Indian Medicinal Plant. CDRI, & National Institute of Science Communication and Information. New Delhi, IV:6-37.
15. Chopra RN. Nayar SL &. Chopra IC. Glossary of Indian Medicinal Plant. NISCAIR Press, New Delhi. Edition VII. 2006:16.
16. The Review of Natural Product. Fact and Comparison 111 West Port Plaza, Missouri. Edition II. 2002: 29-30.
17. Nadkarni KM. The Indian Materia Medica. Bombay Popular Prakashan. Edition III. 2009: 77-79.
18. Verma RK. Mishra G. Singh P. Jha KK & Khosa RL. Alpinia galanga – An Important Medicinal Plant: A review. Der Pharmacia Sinica. 2011; 2: 142-154.
19. Singh BK. Ramakrishna Y. Ngachan SV. Spiny coriander (Eryngium foetidum L.): a commonly used, neglected spicing-culinary herb of Mizoram, India. Genetic Resources and Crop Evolution. 2014;61:1085– 1090. DOI:10.1007/s10722-014-0130-5
20. Bhadwaj S. Gakhar SK. Ethnomedicinal plants used by the tribal of Mizoram to cure cuts and wounds. Indian Journal of Traditional Knowledge. 2005;4: 75-80. http://nopr.niscair.res.in/handle/123456789/8497
21. Lokendrajit N. Devi SI. Swapana N. Singh CB. Ethno-medicinal plants of Manipur used in the treatment of blood pressure. An International Journal of Environment and Biodiversity. 2012; 3: 39-41.
22. Kumar Rai PK. Lalramnghinglova H. Ethnomedicinal Plant Resources of Mizoram, India: Implication of Traditional Knowledge in Health Care System. Ethnobotanical Leaflets. 2010;14:274-305.
23. Baqar SR. Text Book of Economic Botany. Ferozsons (PVT) Ltd, Rawalpindi, Lahore, Karachi. 2001: 23-100.
24. Sharma HK. Chhangte L. Dolui AK. Traditional medicinal plants in Mizoram, India. Fitoterapia 2001; 72: 146-161. https://doi.org/10.1016/S0367-326X(00)00278-1
25. Geneva: WHO; Quality Assurance Pharmaceuticals: A Compendium of Guidelines and Related Materials, Good Manufacturing Practices and Inspection. 1996: pp. 2.
26. WHO Technical Report Series. Geneva: WHO. Guidelines for the Assessment of Herbal Medicines. 1996: pp. 863.
27. Ahmad M. Khan MA. Zafar M. Arshad M. Sultana S. Abbasi BH et al. Use of chemotaxonomic markers for misidentified medicinal plants used in traditional medicines. Journal of Medicinal Plant and Research. 2010; 4: 1244–52.
28. Dhanukar SA. Kulkarni RA. Rege NN. Pharmacology of medicinal plants and natural products. Indian Journal of Pharmacology. 2000; 32: S81-S118.
29. Kumar S. Kumar VV. Prakash O. Microscopic evaluation and physiochemical analysis of Dillenia indica leaf. Asian Pacific Journal of Tropical Biomedicine. 2011: 337-340. DOI:10.1016/S2221-1691(11)60076-2
30. Evans WC. Trease and Evans’ Pharmacognosy, 16th Edition, Edinburg. Saunders Elsevier. 2009: pp.541- 570.
31. Wallis TE. Textbook of Pharmacognosy. 5th edition. 2004: pp.572-582.
32. Kokate CK. Purohit AP. Gokhale SB. Pharmacognosy (Volume I & II), Nirali Prakashan, Pune (India), (2012) pp.6.3-6.25(Vol-I);pp. A.1-A.6(Vol-II).
33. Khandelwal KR. Practical Pharmacognosy, Nirali Prakashan, Pune. 2008;52-70,134, 123-127,155-156.
34. Khadabadi SS. Deore SL. Baviskar BA. Experimental Phytopharmacognosy, Nirali Prakashan, Pune. 2011;3:1-3.8., 4.2-4.38, A2.1-A2.2.
35. World Health Organization. Quality control methods for medicinal plant materials,WHO/PHARM/92.559. 1998;4-46.
36. Malsawmtuangi C. Thanzami K. Lalhlenmawia H. Selvan V. Palanisamy S. Kandasamy R. Pachuau L et al. Physicochemical characteristics and antioxidant activity of Prunus cerasoides D. Don gum exudates. International Journal of Biological Macromolecules. 2014; 69: 192-199. DOI:10.1016/j.ijbiomac.2014.05.050
37. Kar B. SureshKumar SRB. Karmakar I. Dola N. Bala A. Mazumder UK. Pallab Khadar P. et al. Antioxidant and in-vitro anti-inflammatory Activities of Mimusops Elengi Leaves. Asian Pacific Journal of Tropical Biomedicine. 2012: S976-S980. DOI:10.1016/S2221-1691(12)60346-3
38. Singh S. Machawal L. Chauhan MG. Pharmacognostic study of male leaves of Trichosanthes dioica Roxb. with special emphasis on microscopic technique. Journal of Pharmacognosy and Phytotherapy. 2010; 2: 71-75.
39. Nayak BS. Patel KN. Pharmacognostic studies of the Jatropha curcas leaves. International Journal of Pharm Tech Research. 2002; 2:140-143.
40. Thomas S, Patil DA. Patil AG. Chandra N. Pharmacognostic evaluation and physicochemical analysis of
2. Averrhoa carambola L. fruit. Journal of Herbal Medicine and Toxicology. 2008; 2(2) :51-54.
41. Das NP. Pereira TA. Effect of flavonoids on thermal auto-oxidation of palm oil: structure Activity relationship. Journal of American Oil Chemists Society. 1990; 67(44):255-258. DOI:10.1007/BF02540652
42. Parr A. Bolwell GP. Phenols in the plant and in man: The potential for possible nutritional enhancement of the diet by modifying the phenols content or profile. Journal of the Science of Food and Agriculture. 2000;80: 985-1012. DOI:10.1002/(SICI)1097-0010(20000515)80:7<985::AID-JSFA572>3.3.CO;2-Z
43. Kondragunta. KV. Karuppuraj. V. Perumal. K. Antioxidant activity and Folic acid content in indigenous isolates of Ganoderma lucidum. Asian Journal of Pharmaceutical Analysis. 2016; 6(4): 213-215. DOI:10.5958/2231-5675.2016.00032.6
44. Elayarani M. Shanmuganathan P. Muthukumaran P. In Vitro Anti-Oxidant Activity of the Various Extracts of Cassia auriculata L. Flower by UV Spectrophotometer. Asian Journal of Pharmacy and Technology. 2011; 1(3): 70-72.
45. Mohamed STK. Azeem AK. Dilip C. Sankar C. Prasanth NV. Duraisami R. et al. Anti- inflammatory activity of the leaf extacts of Gendarussa vulgaris Nees. Asian Pacific Journal of Tropical Biomedicine. 2011; 1: 147-149. DOI:10.1016/S2221-1691(11)60014-2
46. Anbarasi A. Vidhya R. Evaluation of In Vitro Anti- Inflammatory Activity of Tephrosia purpurea (Seed). Asian Journal of Pharmaceutical Research. 2015; 5(2): 83-89. DOI:10.5958/2231-5691.2015.00012.X
47. Gorla US. Savithri M. Rao GSNK. Niharika Y. Sathya PDS. Harika V. Evaluation of anti-inflammatory activity of Hydroalcoholic extract of Ananas cosmosus fruit peel by HRBC membrane stabilisation. Asian Journal of Pharmaceutical Research. 2018; 8(1):33-35. DOI:10.5958/2231-5691.2018.00006.0