ABSTRACT:
Despite advancements in science and technology and newer innovations in drug delivery, the oral route is still the most popular route for administering the drugs. The tremendous measures are adopted to make it as cost-effective, non-invasive, and self-administrative process for improving patient compliance. It has found acceptance from people of all ages, especially children and old age, as there is difficulty in swallowing the tablet. The longing efforts have made to improve the flavor and taste of orally managed tablets that prompted the advancement of numerous medicines with improved acceptance and palatability. Mouth dissolving tablets (MDTs) have become progressively prominent in recent decades, and this field has turned into a quickly developing territory in the pharmaceutical industries. One of the promising characteristics of MDTs is the quick disintegration in the mouth when mixed with saliva and provides a pleasant and sweet taste for disagreeable medicines. This article surveys the past utilizations and newer techniques adopted by descriptors for taste concealing. It projects the most recent improvements and strategies taken for diminishing the sharpness for oral pharmaceuticals. It further highlights the problems faced by paediatrics and geriatrics patients in the swallowing of tablets and also adopted for the disintegration of the tablet in the mouth to enhance patient compliance and acceptability through ease of administration at an affordable cost. The incorporation of superdisintegrants employed for the development of the MDTs and other formulation aspects promotes the use of MDTs in pharmaceutical industries from a research point of view.
Cite this article:
Jitendra Gupta. Mouth Dissolving Tablets: An Insight into Challenges and Future Prospects of Technologies in Pharmaceutical Industries. Research Journal of Pharmacy and Technology. 2022; 15(11):5068-7. doi: 10.52711/0974-360X.2022.00852
Cite(Electronic):
Jitendra Gupta. Mouth Dissolving Tablets: An Insight into Challenges and Future Prospects of Technologies in Pharmaceutical Industries. Research Journal of Pharmacy and Technology. 2022; 15(11):5068-7. doi: 10.52711/0974-360X.2022.00852 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-11-37
REFERENCES:
1. Gupta K and Singhvi I. Formulation, characterization and optimization of mouth dissolving tablets of diacerein: β-cyclodextrin solid dispersion. Asian Journal of Pharmaceutical Research and Development. 2015; 3(5): 1-16.
2. Cheng R, Guo X, Burusid B. and Couch R. A review of fast dissolving tablets. Pharmaceutical Technology. 2000; June: 52-58.
3. Bi Y, Sunada H, Yonezawa Y, Dayo K, Otsuka A. and Iida K. Preparation and evaluation of compressed tablet rapidly disintegrating in oral cavity. Chemical and Pharmaceutical Bulletin. 1996; 44(11): 2121-2127.
4. Quick dissolving tablets. http:/www.biospace.com. (Accessed on Feb 6, 2020).
5. Kuccherkar BS, Badhan AC. and Mahajan HS. Mouth dissolving tablets: A novel drug delivery system. Pharm Times. 2003; 35: 3-10.
6. Fu Y, Yang S, Jeong SH, Kimura S. and Park K. Orally fast disintegrating tablets: Developments, technologies, taste-masking and clinical studies. Critical Reviews in Therapeutic Drug Carrier Systems. 2004; 21(6): 433-476.
7. Bandari S, Mittapalli RJ, Gannu R. and Rao YM. Orodispersible tablets: An overview. Asian Journal of Pharmaceutics. 2008; 2(1): 1-11.
8. Indurwade NH, Rajyaguru TH. and Nakhat PD. Novel approach: Fast dissolving tablets. Indian Drugs. 2002; 39(8): 405‐41.
9. Bradoo R, Shahani S, Poojary S, Deewan B. and Sudarshan S. Fast Dissolving Drug Delivery Systems. JAMA India. 2011; 4(10): 27-31.
10. Masih A, Kumar A, Singh S. and Tiwari AK. Fast dissolving tablets: A review. International Journal of Current Pharmaceutical Research. 2017; 9(2): 8-18.
11. Gohel M, Patel M, Amin A, Agrawal R. and Dave R, Bariya N. Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique. AAPS PharmSci Tech. 2004; 5(3):10-15.
12. Wilson CG, Washington N, Peach J, Murray GR. and Kennerley J. The behavior of a fast dissolving dosage form (Expidet) followed by γ-scintigraphy. International Journal of Pharmaceutics. 1987; 40(1-2): 119-123.
13. Fix JA. Advances in quick-dissolving tablets technology employing Wowtab. Paper Presented at: IIR Conference on Drug Delivery Systems, Oct.; Washington DC, USA, 1998.
14. Virely P. and Yarwood R. Zydis - A novel, fast dissolving dosage form. Manufacturing Chemist. 1990; 61: 36–37.
15. Reddy LH, Ghosh B. and Rajneesh. Fast dissolving drug delivery system: A review of literature. Indian Journal of Pharmaceutical Sciences. 2002; 64(4): 331‐336.
16. Habib W, Khankari R. and Hontz J. Fast‐dissolving drug delivery systems. Critical Reviews in Therapeutic Drug Carrier Systems. 2002; 17(1): 61‐72.
17. Nand P, Vashist N, Anand A. and Drabu S. Mouth dissolving tablets- A novel drug delivery system. International Journal of Applied Biology and Pharmaceutical Technology. 2010; 1(3): 20.
18. Behnke K, Sogaard J, Martin S, Bauml J, Ravindran AV, Agren H. and Vester-Blokland ED. Mirtazapine orally disintegrating tablet versus sertraline: A prospective onset of action study. Journal of Clinical Psychopharmacology. 2003; 23(4): 358-364.
19. Kumar S. and Garg SK. Fast dissolving tablets (FDTS): Current status, new market opportunities, recent advances in manufacturing technologies and future prospects. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6(7): 22-35.
20. Shrivastava P. and Sethi V. A review article on: Superdisintegrants. International Journal of Drug Research and Technology. 2013; 3(4): 76-87.
21. Gauri S. and Kumar G. Fast dissolving drug delivery and its technologies. The Pharma Innovation. 2012; 1(2): 34-39.
22. Badgujar BP. and Mundada AS. The technologies used for developing orally disintegrating tablets: A review. Acta Pharmaceutica. 2011; 61(2): 117–139.
23. Bhaskaran S. and Narmada GV. Rapid dissolving tablet: A novel dosage form. Indian Pharmacist. 2002; 1(6): 9-12.
24. Saroha K, Mathur P, Verma S, Syan N. and Kumar A. Mouth dissolving tablets: An overview on future compaction in oral formulation technologies. Der Pharmacia Sinica. 2010; 1(1): 179-187.
25. Bess WS, Kulkarni N, Ambike SH. and Ramsay MP. Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1. US Patent 7067116, Jun 27, 2006.
26. Hughes Medical Corporation. Fast Dissolving Films. http://www.hughes-medical.com/products/fast-dissolving-film.htm (Accessed on March 26, 2020)
27. Bagul U, Gujar K, Patel N, Aphale S. and Dhat S. Formulation and evaluation of sublimed fast melt tablets of levocetirizine dihydrochloride. International Journal of Pharmaceutical Sciences. 2010; 2(2): 76-80.
28. Kalia A, Khurana S. and Bedi N. Formulation and evaluation of mouth dissolving tablets of oxcarbazepine. International Journal of Pharmacy and Pharmaceutical Sciences. 2009; 1(1): 12-23.
29. Rishi RK. A review on fast dissolving tablets techniques. Pharma Review. 2004; 2: 32.
30. Kuchekar SB, Badhan CA. and Mahajan SH. Mouth dissolving tablets: A novel drug delivery system. Pharma Times. 2003; 35: 7-9.
31. Abdelbary G, Prinderre P, Eouani C, Joachim J, Reynier JP. and Piccerelle P. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. International Journal of Pharmaceutics. 2004; 278(2): 423-433.
32. Siddiqui MN, Garg G. and Sharma PK. Fast dissolving tablets: Preparation, characterization and evaluation: An overview. International Journal of Pharmaceutical Sciences Review and Research. 2010; 4(2): 87-96.
33. Koizumi K, Watanabe Y, Morita K, Utoguchi N. and Matsumoto M. New method of preparing high-porosity rapidly saliva soluble compressed tablets using mannitol with camphor: A subliming material. International Journal of Pharmaceutics. 1997; 152(1): 127-131.
34. Kaushik D, Dureja H. and Saini TR. Orally disintegrating tablets: An overview of meltin mouth tablet technologies and techniques. Tablets and Capsules. 2004; 2(4): 30-36.
35. Sreenivas SA, Dandagi PM, Gadad AP, Godbloe AM, Hiremath SP. and Mastiholimath VS. Orodispersible tablets: New-fangled drug delivery systems-A review. Indian Journal of Pharmaceutical Education and Research. 2005; 39(4): 177-181.
36. Kumar D, Sharma I. and Sharma V. A comprehensive review on fast dissolving tablet technology. Journal of Applied Pharmaceutical Science. 2011; 1(5): 50-58.
37. Wehling F. and Schuehle S. Base coated acid particles and effervescent formulation incorporating same. US Patent 5, 503, 846; April 2, 1996.
38. Wehling F, Schuehle S. and Madamala N. Effervescent dosage form with microparticles. US Patent 5,178,878; Jan 12, 1993.
39. Amborn J. and Tiger V. Apparatus for handling and packaging friable tablets. US Patent 6, 311,462, 2001.
40. Seager H. Drug-delivery products and the Zydis fast-dissolving dosage form. Journal of Pharmacy and Pharmacology. 1998; 50(4): 375-382.
41. Gregory GK. and Ho DS. Pharmaceutical dosage form packages. US Patent 4, 305, 502; Dec 15, 1981.
42. Yarwood R, Kearnery P. and Thompson A. Process for preparing solid pharmaceutical dosage form. US Patent 5,738,875; April 14, 1998.
43. Manivannan R. Oral disintegrating tablets: A future compaction. Drug Invention Today. 2009; 1(1): 61-65.
44. Velmurugan S. and Vinushitha S. Oral Disintegrating tablets: An overview. International Journal of Chemistry and Pharmaceutical Sciences. 2010; 1(2): 1-12.
45. Patel ZK, Patel RR, Patel KR. and Patel MR. A review: Formulation of fast dissolving tablet. PharmaTutor. 2014; 2(3): 30-46.
46. Nagar P, Singh K, Chauhan I, Verma M, Yasir M, Khan A, et al. Orally disintegrating tablets: Formulation, preparation techniques and evaluation. Journal of Applied Pharmaceutical Science. 2011; 1(04): 35-45.
47. Comoglu T. and Dilek-Ozyilmaz E. Orally disintegrating tablets and orally disintegrating mini tablets-novel dosage forms for pediatric use. Pharmaceutical Development and Technology. 2019; 24(7): 902–914.
48. Rasheed HS, Arief M, Gajavalli SR, Vani PS, Rao KS, Kumar SLVVSNKS, et al. A Comparison of different superdisintegrants in designing of fast dissolving tablets of salbutamol sulphate. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2011; 2(2): 155-163.
49. Ratnaparkhi MP, Mohanta GP. and Upadhyay L. Review on: Fast dissolving tablet. Journal of Pharmacy Research. 2009; 2(1): 5-12.
50. Savale SK. Pharmaceutical solid dosage forms: in process quality control tests. Asian Journal of Phytomedicine and Clinical Research. 2018; 6(1): 44-54.
51. Patil BS, Kulkarni U, Bhavik P, Soodam SR. and Korwar PG. Formulation and evaluation of mouth dissolving tablets of nimesulide by new coprocessed technique. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2010; 1(4): 587-92.
52. Singh SK, Mishra DN, Jassal R. and Soni P. Fast disintegrating combination tablets of omeprazole and domperidone. Asian Journal of Pharmaceutical and Clinical Research. 2009; 2(3): 1-9.
53. Prajapati BG. and Patel SN. Formulation, evaluation and optimization of orally disintegrating tablet of cinnarizine. e- Journal of Science & Technology. 2010; 5(5): 9-21.
54. Kuchekar BS, Mahajan S. and Bandhan AC. Mouth dissolve tablets of sumatriptan. Indian drugs. 2004; 41(10): 592-98.
55. Lalla JK. and Mamania HM. Fast dissolving rofecoxib tablets. Indian Journal of Pharmaceutical Sciences. 2004; 59(4): 23-26.
56. Mohanachandran PS, Krishnamohan PR, Saju F, Bini KB, Babu B. and Shalina KK. Formulation and evaluation of mouth dispersible tablets of amlodipine besylate. International Journal of Applied Pharmaceutics. 2010; 2(3): 1-6.
57. Bhagat BV, Hapse SA, Jadhav AP, Gawand RB. Mouth dissolving tablet: A formulation approach. Research Journal of Pharmacy and Technology. 2017; 10(1): 355-361. Doi. 10.5958/0974-360X.2017.00072.5
58. Bhagwat A, Kakade SM, Naval CV, Tilker M, Walture RM, SAdichwal SA, et al. Formulation and evaluation of mouth dissolving tablets of domperidone. Research Journal of Pharmacy and Technology. 2010: 3(3): 821-824.
59. Sravanthi N, Alekhya I and Reddy V. Formulation and evaluation of mouth dissolving tablets of clozapine by direct compression method. Research Journal of Pharmacy and Technology. 2017; 10(8): 2543-2550.
60. Nandare DS, Mandlik SK, Khiste SK and Mohite YD. Formulation and optimization of mouth dissolving tablets of olanzapine by using 32 factorial design. Research Journal of Pharmacy and Technology. 2011; 4(8): 1265-1268.
61. Ahad HA, Kumar CS, Reddy KK, Kumar A, Sekhar C, Sushma K, Sairam T. and Sivaji S. A novel technique in formulation and evaluation of mouth dissolving nimesulide tablets. Journal of Advanced Pharmaceutical Research. 2010; 1(2): 101-107.
62. Dholakiya RB, Akbari BV, Shiyani BG, Patel GF, Ramani GK and Vekariya NR. The effect of various superdisintegrating agents on mouth dissolving tablet of ranitidine HCl. Research Journal of Pharmacy and Technology. 2010; 3(1): 175-178.
63. Bhanja S, Deepthi KL, Sudhakar M and Panigrahi BB. Design, optimisation and in-vitro evaluation of mouth dissolving tablets of venlafaxine hydrochloride. Research Journal of Pharmacy and Technology. 2014; 7(5): 502-512.
64. Venkatalakshmi R, Sasikala C and Silambarasan SP. Formulation and evaluation of loperamide hydrochloride mouth dissolving tablet by using super disintegrants. Research Journal of Pharmacy and Technology. 2010; 3(2): 530-534.
65. Venkatalakshmi R, Ho NJ, Sheshala R and Chinnappan S. Formulation and characterization of mouth dissolving tablets of dexamethasone using synthetic superdisintegrants. Research Journal of Pharmacy and Technology. 2018; 11(4): 1429-1435.)
66. Degwy MAAEAAE, Tayel S, Nabarawi MAE. and Rehem RTAE. The effect of using two NSAIDs with different solubility on freeze drying technology. Current Trends in Biotechnology and Pharmacy. 2013; 7(4): 890-903.
67. Sreeja V, Prajapati J, Thakkar V, Gandhi T. and Darji VK. Effect of excipients on disintegration, viability and activity of fast disintegrating tablets containing probiotic and starter cultures. Current Trends in Biotechnology and Pharmacy. 2016; 10(2): 108-117.
68. Balusu H. and Veerareddy PR. Formulation and evaluation of fast disintegrating zolmitriptan sublingual tablets. Current Trends in Biotechnology and Pharmacy. 2012; 6(1): 84-98.
69. Gupta J, Mohan G, Prabakaran L and Gupta R. Effects of formulation and process variables on aceclofenac loaded ethyl cellulose microspheres. International Journal of Drug Development & Research. 2013; 6(1): 293-302.
70. Akhter MH, Gupta J, Faisal MS and Mohiuddin M. A Comprehensive review on buccal drug delivery systems. International Journal of Pharmaceutical Research and Development. 2012; 3(11): 59-77.
71. Swamivelmanickam M, Venkatesan P and Sangeetha G. Preparation and evaluation of mouth dissolving tablets of loratadine by direct compression method. Research Journal of Pharmacy and Technology. 2020; 13(6): 2629-2633.
72. Deshmukh KR, Pandey A, Pandey A, Patel V, Verma S, Dewangan P, et al. Deshmukh G. Design and development of loratadine containing mouth dissolving tablets. Research Journal of Pharmacy and Technology. 2011; 4(11): 1676-1681.