Author(s): Hassan Jaddi, Ahmed Moussaif, Laila. Benbacer, Mohammed Attaleb, Mohamed Ellouz, Nada Kheira Sebbar


DOI: 10.52711/0974-360X.2022.00879   

Address: Hassan Jaddi1,2*, Ahmed Moussaif1, Laila. Benbacer1, Mohammed Attaleb1, Mohamed Ellouz2, Nada Kheira Sebbar2, Abdelkarim Filali Maltouf2, El Mokhtar Essassi2, Mohammed El Mzibri1
1Life Science Division, National Center for Energy, Sciences and Nuclear Techniques. Rabat. Morocco.
2Faculty of Sciences, Mohammed V University. Rabat. Morocco.
*Corresponding Author

Published In:   Volume - 15,      Issue - 11,     Year - 2022

A new benzothiazine: 4-(oxiran-2-ylmethyl)-1,4-benzothiazin-3-one was synthesized by a liquid-solid phase transfer catalysis reaction. The new compound was well characterized by FT-IR spectroscopy, the nuclear resonance of proton and carbon 13, and mass spectrometry. The genotoxicity of the new benzothiazine derivative was assessed using the micronucleus assay on Chinese Hamster Ovary cells (CHO cells), as compared to its cytotoxicity against CHO cells. Accordingly, the chromosomal damages were detected with micronucleus frequency (MN) and cytotoxicity was assessed with cyto-blocking proliferation index (CBPI). The newly synthesized benzothiazine derivative was not cytotoxic and don't exhibit, in absence of metabolic activation, any genotoxic effect, making it a potential chemical for further biological explorations and an interesting scaffold for new derivatives.

Cite this article:
Hassan Jaddi, Ahmed Moussaif, Laila. Benbacer, Mohammed Attaleb, Mohamed Ellouz, Nada Kheira Sebbar. Synthesis and genotoxic evaluation of a 4-(Oxiran-2-ylmethyl)-1,4-benzothiazin-3-one. Research Journal of Pharmacy and Technology. 2022; 15(11):5217-4. doi: 10.52711/0974-360X.2022.00879

Hassan Jaddi, Ahmed Moussaif, Laila. Benbacer, Mohammed Attaleb, Mohamed Ellouz, Nada Kheira Sebbar. Synthesis and genotoxic evaluation of a 4-(Oxiran-2-ylmethyl)-1,4-benzothiazin-3-one. Research Journal of Pharmacy and Technology. 2022; 15(11):5217-4. doi: 10.52711/0974-360X.2022.00879   Available on:

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