Many infectious diseases in ancient times have been treated using herbal drugs. Today efforts are made for the discovery of the herbal components from plants possessing antimicrobial properties. Herbal drugs are widely used for treatment of various diseases, and they play an important role in health care considerations. Rhizome of Inchnocarpus frustescens were extracted, phytochemically investigated and were subjected to antibacterial as well as antifungal screening by Disk Diffusion Method. The Minimum Inhibitory Concentration (MIC) was also performed by two-fold tube dilution method. Three compounds were isolated and identified as n-nonadecanyl benzoate (1), benzocosanyl arachidate (2), and Quercetin (3). The result of phytochemical investigation showed that compound (3) is new isolated the first time from rhizomes; and compounds (1)and (2) are isolated from genus Ichnocarpus frutescens form other morphological parts earlier. Further antimicrobial tests indicated that the ethanolic extract inhibited the growth of all microorganisms and most extracts showed promising degree of antimicrobial activity. The results were compared with standard antimicrobial agents (Erythromycin and Fluconazole), Thus providing evidence for the potential use of these crude extract in the treatment of bacterial and fungal infections.
Cite this article:
Gauri Pai Angle, Saumya Vernekar. Phytochemical Investigation and Antimicrobial Activity of Inchnocarpus frustescens Rhizome. Research Journal of Pharmacy and Technology. 2022; 15(2):512-6. doi: 10.52711/0974-360X.2022.00082
Gauri Pai Angle, Saumya Vernekar. Phytochemical Investigation and Antimicrobial Activity of Inchnocarpus frustescens Rhizome. Research Journal of Pharmacy and Technology. 2022; 15(2):512-6. doi: 10.52711/0974-360X.2022.00082 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-2-2
1. Muthukumaran P, Padmapriya P , Salomi S, Umamaheshwari R, Kalaiarasan P, Malarvizhi C. In Vitro Anti Microbial Activity of Leaf Powder. Asian J. Pharm. Res. 2011;1(4): 108-110.
2. Satyapal U , Mahajan D , Tatke P, Naharwar V. Phytochemical Investigation and Assessment of Antioxidant and Antimicrobial Potential of Bark of Mimusops elengi. Research J. Pharm. and Tech. 2014; 7(11): 1226-30.
3. Srinivasan D, Nathan S, Suresh T, Perumalsamy O.Antimicrobial activity of certain Indian medicinal plants used in folkloric medicine. J Ethnopharmacol 74: 217-220.
4. Tiwari P. Antimicrobial Activity of Amritarishta Prepared by Traditional and Modern Methods. Asian J. Pharm. Res. 2014; 4(2): 114-116.
5. Singh N, Mani T, Prakash D, Singh P. A Review on Medicinal Properties of Ichnocarpous frutescens. Indian J of Novel Drug Delivery. 2012; 4(1): 24-27.
6. Dash DK, Nayak SS, Samanta S, Ghosh T, Jha T, Maiti BC et al. Antitumor activity and Antioxidant Role ofIchnocarpus frutescens Against Ehrlich Ascites Sarcinoma in Swiss Albino Mice. Natural Product Sciences. 2007; 13(1): 54-60.
7. Srujana M, Lakshmidevi N. Phytochemical Screening And Mic Determination of Different Extracts of Ichnocarpus Frutescens. Int J Pharm Bio Sci. 2016;7(4): 949-953.
8. Anonymous. The wealth of India-A dictionary of Indian raw materials and industrial products. Raw materials, New Delhi, CSIR, 1959, 62-163.
9. Kirtikar KR, Basu BD. Indian Medicinal Plants,Allahabad, Lalit Mohan Basu Publications, 1982, 1590-1592.
10. Kumar.S G, Noorjahan, G. Reddy S, Syed KM, Ashwini T, Chary VM. Extraction, Phytochemical Studies and In–Vitro Screening of the Leaves and Flowers of Crossandra infundibuliformis against Mycobacterium tuberculosis. Asian J. Res. Pharm. Sci. 2018; 8(4): 247-252
11. Mohite SA, Shah RR, Patel NR. Antimicrobial Activity of Leaves extracts of Jatropha curcas. Asian J. Pharm. Res. 2018; 8(1): 17-20.
12. Rajisha K, Fernanades J. Pharmacognostic and Preliminary Phytochemical Investigation of Exacum bicolor Roxb. Research J. Pharm. and Tech. 2020; 13(4): 1752-1756.
13. Sardessai Y, Pai Angle G, Joshi A, Carvalho S, Bhobe M.Antimicrobial activity of methanolic extract of therhizomes of costus igneus.J Pharm Chem Biol Sci. 2014;2(3):176-185.
14. Shrivastava K, Sahu S, Skand K. Kantishree De. In vitro Antimicrobial Activity and Phytochemical Screening of Syzygium aromaticum. Asian J. Res. Pharm. Sci.Jan.-Mar. 2014;4(1):12-15.
15. Thilagavathi T, Kathiravan G. Phytochemical Analysis and Antimicrobial Activity of Ethonolic Leaf Extract of Ficus racemosa Linn. Research J. Pharm. and Tech. 2017; 10(2): 537-540.
16. Kumar S, Kamraj M. Antimicrobial activity of Cucumis anguria L. By agar well diffusion method. Botany Research International, 2011; 4(2): 41-42.
17. Farrukh, R, Zargar MA, Akhtar A, Tasduq SA. Antibacterial and Antifungal activity of Thymus sepeyllum. Botany Research International, 2012; 5(2): 36-39.
18. Tyagi R, Shukla A, Shukla RK. Phytochemical screening and pharmacological evaluation of different extracts of plantcasearia tomentosa leaves. Int J Pharm Pharm Sci 2017;9:166-71.
19. Pai Angle G, Sardessai Y. Antimicrobial activity of the roots of Ichnocarpus frutescens. International Journal of Herbal Medicine 2017; 5(5): 221-224.
20. Byahatti VV, Khan AM , Patil SH Choudhury A. Preliminary Phytochemical Investigation and In-vitro Antioxidant Activity of Bergenia ciliata Leaves. Research J. Pharm. and Tech. 2010; 3(2):399-401.
21. Naidu ST, Emmanuel S, Sheeba Rani M. A Phytopharmacological review on Ichnocarpus frutescens. Research J. Pharm. and Tech. 2013; 6(6): 607-9
22. Bhimanwar R, Kothapalli L, Khawshi A . Quercetin as Natural Bioavailability Modulator: An Overview. Research J. Pharm. and Tech 2020; 13(4):2043-2050.
23. Shekhaar H B, Rajiniraja M. Favorable binding of Quercetin to α-Synuclein as potential target in Parkinson disease: An Insilico approach. Research J. Pharm. and Tech. 2018; 11(1): 203-206
24. Shanaida M, Pryshlyak A, Olena Golembiovska. Determination of Triterpenoids in Some Lamiaceae Species. Research J. Pharm. and Tech 2018; 11(7): 3113-3118.