Shunmugaram S, Muthu Kumar N J, Mahalakshmi V, Mahadevan M V, Periyasami D, Samundeeswari P
Shunmugaram S1*, Muthu Kumar N J2, Mahalakshmi V3, Mahadevan M V4, Periyasami D5, Samundeeswari P6
1Research Officer (S), Siddha Regional Research Institute, Central Council for Research in Siddha, Puducherry.
2HOD, Dept. of Sirappu Maruthuvam, National Institute of Siddha, Tambaram Sanatorium, Chennai.
3Associate Professor, Dept of Sirappu Maruthuvam, National Institute of Siddha, Chennai.
4,5,6Lecturers, Dept of Sirappu Maruthuvam, National Institute of Siddha, Chennai.
Volume - 15,
Issue - 2,
Year - 2022
An open clinical trial conducted to access the safety and efficacy of Pachai Karpoora Vadagam (PKV) and Vaeppa Ennai (VE) in the management of Azhal Keel Vayu (AKV) is one among 10 types of Keel Vayu diseases particularly occurring in joints. The trial was conducted at OPD/IPD of Ayothidoss Pandithar Hospital, in accordance with the standard study protocol duly approved by the Institutional Ethics Committee (IEC) of National Institute of Siddha. The clinical study is registered in Clinical Trials Registry – India. Duly signed informed consent was obtained from every patient before trial enrollment. Among 40 subjects, 20 subjects were treated on OPD basis and remaining 20 subjects were admitted in IPD for 48 days. Trial subjects were screened and documented by the standard screening proforma. Universal pain assessment scale was used to assess the trial outcome. Clinical assessment was done on every 7th day and prognosis was noted in the prescribed proforma, daily in IPD subjects. Paired‘t’ test was used to test the significance of treatment. The study revealed statistical significance of pain score before and after treatment of Pachai Karpoora Vadagam (PKV) and Vaeppa Ennai (VE) (p <0.001). There are no significant statistical changes of safety parameters such as Liver Function Test and Renal Function Test before and after treatment. Hence it is concluded that the drugs are safe and effective in the management of AKV (Osteoarthritis).
Cite this article:
Shunmugaram S, Muthu Kumar N J, Mahalakshmi V, Mahadevan M V, Periyasami D, Samundeeswari P. A Clinical Study to Evaluate the Safety and efficacy of Pachai Karpoora Vadagam (Internal Medicine) and Vaeppa Ennai (External Medicine) on Azhal Keel Vayu (Osteoarthritis). Research Journal of Pharmacy and Technology. 2022; 15(2):611-4. doi: 10.52711/0974-360X.2022.00100
Shunmugaram S, Muthu Kumar N J, Mahalakshmi V, Mahadevan M V, Periyasami D, Samundeeswari P. A Clinical Study to Evaluate the Safety and efficacy of Pachai Karpoora Vadagam (Internal Medicine) and Vaeppa Ennai (External Medicine) on Azhal Keel Vayu (Osteoarthritis). Research Journal of Pharmacy and Technology. 2022; 15(2):611-4. doi: 10.52711/0974-360X.2022.00100 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-2-20
1. Kandaswamy Pillai N, History of Siddha Medicine, Published by Government of Tamilnadu, 1979.
2. Siddha Maruthuvam Pothu, Ka. Na Kuppusamymuthaliyar.; 7th edition; Page no: 626-627; Pub: Deparment of Indian medicine and Homeopathy, Chennai – 600106.
3. Rachel Wittenauer et al., Priority Medicines for Europe and the World . A Public Health Approach to Innovation", Background Paper 6.12, Osteoarthritis, January 28th 2013.
4. Behzad Heidari. Knee osteoarthritis prevalence, risk factors, pathogenesis and features: Part I, Caspian J Intern Med. 2011; 2(2): 205-212.
5. Anna Litwic, et al., Epidemiology and Burden of Osteoarthritis, The MRC Lifecourse Epidemiology Unit, (University of Southampton), Southampton General Hospital, Southampton SO16 6YD, UK. 7. 2013 July 20.
6. Kanchan R Pagar, Sarika V Khandbahale, Poonam M Kasar. Osteoarthritis: Pathophysiology and Current Treatment Modalities. Asian J. Pharm. Res. 2019; 9(4):289-298.
7. Dr.Chandraprakash pal et al., Epidemiology of knee osteoarthritis in India and related factors, Indian J Orthop. 2016; 50(5): 518–522.
8. Sarumathy S., CH Haripriya, Muddala Vara Prasanna Rao, Gayathri K., CH Bala Sudhakar, Divya M., Shanmugasundaram P. Clinical Comparison of the Efficacy and Safety of Intra-Articular Injections of Sodium Hyaluronate and Methyl Prednisolone in the Treatment of Osteoarthritis of Knee. Research J. Pharm. and Tech. 2015; 8(11): 1526-1528
9. Gopinathan NR, Sen RK, Behera P, Aggarwal S, Khandelwal N, Sen M. Awareness of osteoporosis in postmenopausal Indian women: An evaluation of Osteoporosis Health Belief Scale. J Mid-life Health 2016; 7:180-4.
10. Instruments, Pain Intensity. "0–10 Numeric Rating Scale (page." (2003).
11. Sniekers, Y.H., Weinans, H., van Osch, G.J. et al. Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis. Arthritis Res Ther. 12, R182 (2010). https://doi.org/10.1186/ar3148
12. Soane K.M. Chaves, Chistiane M. Feitosa and Lidiane da S. Araújo, Alkaloids Pharmacological Activities - Prospects for the Development of Phyto pharmaceuticals for Neurodegenerative Diseases. Current Pharmaceutical Biotechnology. 2016; 17 (7): 629-635.
13. Kumar, Rakesh, Anjum, Nishat and Tripathi, Yogesh. Phytochemistry and Pharmacology of Santalum album L.: A Review. World Journal of Pharmaceutical Research. 2015; 4: 1842-1876.
14. Kumar, Sanjay, et al. Analgesic effect of neem (Azadirachta indica) seed oil on albino rats. Pain 7 (1946).
15. Naik, Manas Ranjan, et al. Study of anti-inflammatory effect of neem seed oil (Azadirachta indica) on infected albino rats. Journal of Health Research and Reviews. 2014; 1.3: 66.
16. Shunmugaram, S. Physiochemical and Acute Toxicity Analysis of a Siddha Herbo-Mineral Formulation-Pachai Karpoora Vadagam (PKV). Research Journal of Pharmacy and Technology. 2019; 12.1: 227-230.