Author(s): Rina Maskare, Shital Thakre, Vithika Gupta, Manisha Basantwani, Ayush Kshirsagar, Triveni Bahekar, Akash Jaiswal

Email(s): rinamaskare@yahoo.co.in

DOI: 10.52711/0974-360X.2022.00124   

Address: Rina Maskare*, Shital Thakre, Vithika Gupta, Manisha Basantwani, Ayush Kshirsagar, Triveni Bahekar, Akash Jaiswal
Manoharbhai Patel Institute of B-Pharmacy, Kudwa, Gondia-441614, Maharashtra.
*Corresponding Author

Published In:   Volume - 15,      Issue - 2,     Year - 2022


ABSTRACT:
An emulgel formulation was developed for a topical non-steroidal anti-inflammatory agent using carbopol as the gelling agent. The effect of concentrations of oil, surfactant and gelling agent on the in-vitro drug release pattern was investigated using 23 factorial design. The optimized emulgel formulations were characterized for appearance, color, pH, homogeneity, viscosity and spreadability. The in-vitro release profile drug from the emulgel formulation was strongly affected by the concentration of gelling agent, surfactants and oil. Stability studies were conducted at different temperatures and humidity conditions that indicated the formulations to be stable under accelerated conditions. No erythema or irritation was observed during the skin irritation studies on rabbits. Optimized formulation showed comparable analgesic and anti-inflammatory activity when they compared with marketed Nurofen gel. So, it can be concluded that topical emulgel of dexibuprofen posses an effective anti-inflammatory and analgesic activity.


Cite this article:
Rina Maskare, Shital Thakre, Vithika Gupta, Manisha Basantwani, Ayush Kshirsagar, Triveni Bahekar, Akash Jaiswal. Formulation and Evaluation of Emulgel for Topical Delivery of Dexibuprofen. Research Journal of Pharmacy and Technology. 2022; 15(2):745-0. doi: 10.52711/0974-360X.2022.00124

Cite(Electronic):
Rina Maskare, Shital Thakre, Vithika Gupta, Manisha Basantwani, Ayush Kshirsagar, Triveni Bahekar, Akash Jaiswal. Formulation and Evaluation of Emulgel for Topical Delivery of Dexibuprofen. Research Journal of Pharmacy and Technology. 2022; 15(2):745-0. doi: 10.52711/0974-360X.2022.00124   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-2-44


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