Mya Mya Thwin, Pyae Phyo Maung, Htet Htet Oo, Mar Mar Lwin, KhinThan Yee, Ma Saung Oo, Min Swe Zaw, Minn Han, Soe Minn Htway
Mya Mya Thwin2*, Pyae Phyo Maung1, Htet Htet Oo1, Mar Mar Lwin4, KhinThan Yee4, Ma Saung Oo2, Min Swe Zaw2, Minn Han3, Soe Minn Htway1
1Department of Physiology, University of Medicine, Magway, Myanmar.
2Medical Faculty, University Sultan Zainal Abidin, Kuala Terengganu, Malaysia.
3Dental Association, Myanmar.
4Faculty of Medicine and Health Sciences, University Malaysia Sarawak.
Volume - 15,
Issue - 2,
Year - 2022
Introduction: The menstrual cycle involves a sequence of structural, functional, and hormonal changes in the reproductive system. This is linked and controlled by cyclical fluctuations in the levels of FSH, LH, estrogen, and progesterone. Because of these cyclical fluctuations, there might also be associated cyclical changes of magnesium and systemic arterial blood pressures during the menstrual cycle. Purpose: To assess the changes in serum magnesium level and systemic arterial blood pressures during the menstrual cycle in young reproductive women. Methodology: the sample population is 40 apparently healthy young reproductive-aged 18- 25years female students from the University of Medicine, Magway participated in this study. Systemic arterial blood pressures were measured by indirect method. The serum magnesium level was measured by spectrophotometry. These measurements were done in the early follicular phase (EF), the peri-ovulatory phase (PO), and the mid-luteal phase (ML) of the menstrual cycle. The serum magnesium levels were significantly (p <0.001) lower, and the systolic blood pressures were significantly higher (p <0.05) in the PO than the EF and the ML. In the EF, there was a significant negative correlation between serum magnesium level and diastolic blood pressure (r= -0.374, p <0.05) and mean arterial pressure (r = -0.354, p < 0.05) but no significant correlation with systolic blood pressure. In the PO, there was no significant correlation between serum magnesium level and systemic arterial blood pressures. In the ML, there was significant negative correlation between serum magnesium level and systolic blood pressure (r = -0.651, p <0.001), diastolic blood pressure (r = -0.607, p <0.001), and mean arterial pressure (r = -0.661, p <0.001). Conclusion: The study concludes that serum magnesium level has a negative effect on blood pressure changes and the blood pressure-lowering effect of magnesium. These changes are related to the fluctuation of estrogen levels during the menstrual cycle.
Cite this article:
Mya Mya Thwin, Pyae Phyo Maung, Htet Htet Oo, Mar Mar Lwin, KhinThan Yee, Ma Saung Oo, Min Swe Zaw, Minn Han, Soe Minn Htway. Fluctuations in Serum magnesium and Systemic Arterial Blood Pressures during the Menstrual Cycle in young reproductive women. Research Journal of Pharmacy and Technology. 2022; 15(2):751-6. doi: 10.52711/0974-360X.2022.00125
Mya Mya Thwin, Pyae Phyo Maung, Htet Htet Oo, Mar Mar Lwin, KhinThan Yee, Ma Saung Oo, Min Swe Zaw, Minn Han, Soe Minn Htway. Fluctuations in Serum magnesium and Systemic Arterial Blood Pressures during the Menstrual Cycle in young reproductive women. Research Journal of Pharmacy and Technology. 2022; 15(2):751-6. doi: 10.52711/0974-360X.2022.00125 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-2-45
1. Bayer SR, DeCherney AH. Clinical manifestations and treatment of dysfunctional uterine bleeding. JAMA. 1993 Apr 14; 269(14):1823-8.
2. Ganong WF (2010). The Gonads: Development and function of the reproductive system, Chapter 25, Review of Medical Physiology. 23rd ed., Singapore: McGraw Hill: 411-422.
3. Olayaki LA, Salman TM, Ayinla MT, Soladoye AO. Plasma magnesium and cardiovascular changes during menstrual cycle in young Nigerian women. Tropical Journal of Health Sciences. 2008 Oct 23; 15(2):24-8.
4. Seelig MS. Interrelationship of magnesium and estrogen in cardiovascular and bone disorders, eclampsia, migraine and premenstrual syndrome. Journal of the American College of Nutrition. 1993 Aug 1; 12(4):442-58.
5. Artraga E, Rojas A, Villaseca P, Bianchi M. The effect of 17beta-estradiol and alpha-tocopherol on the oxidation of LDL cholesterol from postmenopausal women and the minor effect of gamma-tocopherol and melatonin. Menopause (New York, NY). 2000 Mar 1; 7(2):112-6.
6. Dincer Y, Ozen E, Kadioglu P, Hatemi H, Akçay T. Effect of sex hormones on lipid peroxidation in women with polycystic ovary syndrome, healthy women, and men. Endocrine Research. 2001 Jan 1; 27(3):309-16.
7. Ha EJ, Smith AM. Plasma selenium and plasma and erythrocyte glutathione peroxidase activity increase with estrogen during the menstrual cycle. Journal of the American College of Nutrition. 2003 Feb 1; 22(1):43-51.
8. Seelig M. Cardiovascular consequences of magnesium deficiency and loss: pathogenesis, prevalence and manifestations—magnesium and chloride loss in refractory potassium repletion. The American Journal of Cardiology. 1989 Apr 18; 63(14):G4-21.
9. Rardon DP and Fisch C (1990). Electrolytes and the Heart. In The Heart, 7 th edition (Ed. Hurst JW). McGraw-Hill Book Co., New York: 1567.
10. Arsenian MA. Magnesium and cardiovascular disease. Progress in Cardiovascular Diseases. 1993 Jan 1; 35(4):271-310.
11. Dunne FP, Barry DG, Ferriss JB, Grealy G, Murphy D. Changes in blood pressure during the normal menstrual cycle. Clinical Science. 1991 Oct; 81(s25):515-8.
12. Dullo P, Vedi N. Changes in serum calcium, magnesium and inorganic phosphorus levels during different phases of the menstrual cycle. Journal of Human Reproductive Sciences. 2008 Jul; 1(2):77.
13. Htet-Htet-Oo (2010). Serum calcium, magnesium and calcium magnesium ratio in women with premenstrual syndrome. M.Med.Sc (Physiology) thesis, University of Medicine (2), Yangon.
14. Lanje MA, Bhutey AK, Dhawle UP and Sande AS). Serum electrolytes during different phases of menstrual cycle. International Journal of Pharmacological Sciences and Research 2010; 1(10): 435-437.
15. Luepker RV, Evans A, McKeigue P, Reddy KS. Cardiovascular survey methods. World Health Organization; 2004.
16. Rosenstein DL, Elin RJ, Hosseini JM, Grover G, Rubinow DR. Magnesium measures across the menstrual cycle in premenstrual syndrome. Biological Psychiatry. 1994 Apr 15; 35(8):557-61.
17. Nishtha V (2012). Blood pressure and heart rate variability as function of ovarian cycle in young women. Ph.D thesis. School of Life Sciences, Pt. Ravishankar Shukla University, Raipur, India
18. Northcott CA, Watts SW. Low [Mg2+] e enhances arterial spontaneous tone via phosphatidylinositol 3-kinase in DOCA-salt hypertension. Hypertension. 2004 Jan 1; 43(1):125-9.
19. Khayam-Bashi H, Liu TZ, Walter V. Measurement of serum magnesium with a centrifugal analyzer. Clinical Chemistry. 1977 Feb 1; 23(2):289-9.