Amol Raj, Manish Kumar Shakya, Talever Singh, Mohit Agrawal, Nishant Singh Katiyar
Amol Raj1*, Manish Kumar Shakya1, Talever Singh1, Mohit Agrawal1, Nishant Singh Katiyar2
1Department of Pharmacology, Rajiv Academy for Pharmacy, NH-2, P.O. Chhatikara, Mathura, (UP), India.
2Faculty of Pharmaceutical Sciences, Rama University, Kanpur, (UP), India.
Volume - 15,
Issue - 2,
Year - 2022
Background: Rheumatoid arthritis is a major auto immune disorder of body and affects the various joints which may lead to physical disability. The leaves of Neolamarckia cadamba (family rubiaceae) have long been used traditionally to treat rheumatoid arthritis. Though, it has not been pharmacologically assessed for rheumatoid arthritis. The current study explores its anti-arthritic mechanism and phytochemical analysis of ethanolic and aqueous extract of leaves of Neolamarckia cadamba. Methods: Anti-arthritic potential was evaluated through Complete Freund’s Adjuvant (CFA) induced arthritis rats model at 200 mg/kg/p.o doses of the ethanolic and aqueous extracts of Neolamarckia cadamba leaves using Diclofenac sodium as a standard drug. Apart from this we have evaluated parameters like paw edema, body weight, loco motor activity, hematological observations, and radiography etc. Results: The results revealed various arthritic protective mechanisms. Similarly plant exhibited dose dependent anti-arthritic effect with maximum activity observed at 200 mg/kg/ b.w/ p.o.. The results of Complete Freund’s Adjuvant (CFA) model depicted better protection against paw edema and body weight alterations. Also Neolamarckia cadamba leaves extracts remarkably altered locomotion of rats, and positive results were seen in hematological parameters and radiography. Additionally plant exhibited remarkable anti-oxidant activity. Moreover phytochemical analysis revealed polyphenols, anti oxidants and flavanoids. Conclusion: By deeply analyzing the obtained results and data our research work supports the traditional use of Neolamarckia cadamba leaves as a potential anti arthritic agent that may be proposed for rheumatoid arthritis treatment.
Cite this article:
Amol Raj, Manish Kumar Shakya, Talever Singh, Mohit Agrawal, Nishant Singh Katiyar. Evaluation of Anti-arthritic Activity of Leaves Extracts of Neolamarckia cadamba. Research Journal of Pharmacy and Technology. 2022; 15(2):873-7. doi: 10.52711/0974-360X.2022.00146
Amol Raj, Manish Kumar Shakya, Talever Singh, Mohit Agrawal, Nishant Singh Katiyar. Evaluation of Anti-arthritic Activity of Leaves Extracts of Neolamarckia cadamba. Research Journal of Pharmacy and Technology. 2022; 15(2):873-7. doi: 10.52711/0974-360X.2022.00146 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-2-66
1. G. Sivakumar, G. Arihara Sivakumar, Rebecca. Evaluation of Anti-arthritic activity of Methanolic extract of Barleria prionitis on CFA induced rats. Asian J. Pharm. Tech. 2019; 9(3): 159-164.
2. Sujata S. Sawant, Sangram S. Patil, Hemant S. Kandle, Manohar D. Kengar, Ganesh B. Vambhurkar, Mangesh A.Bhutkar. Development and characterization of Lornoxicam loaded microsponge gel for Rheumatoid arthritis. Asian J. Pharm. Tech. 2019; 9(3): 173-178.
3. Spandana K, Varun Teja Chary, Shivani M. Rheumatoid Arthritis. Research J. Pharma. Dosage Forms and Tech. 2019; 11(2): 131-133
4. D.K. Sanghi, S.B. Joshi. Efficacy of an Ayurvedic Formulation in Rheumatoid Arthritis. Research J. Pharmacognosy and Phytochemistry. 2010; 2(4): 306-308
5. Suneel Kumar A, Venkatarathanamma. V, Nageswara Rao Tentu, Pavan Kumar Kota, K.Suneel Kumar, A. Vijayalakshmi. Anti-arthritic Activity of Annona Squamosa Leaves Methanolic Extract on Adjuvant Induced Arthritis in Rats. Res.J. Pharmacology & Pharmacodynamics. 2017; 9(2): 46-56.
6. Rahul Kaushik, Jainendra Jain, Pallavi Rai, Yogesh Sharma, Virender Kumar, Akanksha Gupta. Pharmacognostical, Physicochemical and Preliminary Phytochemical studies of Anthocephalus cadamba (Roxb.) Leaves. Research J. Pharm. and Tech. 2018; 11(4): 1391-1397.
7. Rubi V, Fatma C, Amit S. Neolamarckia Cadamba: A Comprehensive Pharmacological. Glob J Pharmaceu Sci. 2018; 6(4): 555691.
8. B. Arirudran, V. Krishnan, US Mahadeva Rao. Preliminary Phytochemical Analysis and Isolation and Identification of active principle components of petroleum ether extract from leaves of Lawsoniainermis L. Research J. Pharm. and Tech. 2019; 12(8): 3629-3636.
9. Balaji Sujitha, Kavasseri Ganesan Kripa. Anti-arthritic and anti-Inflammatory polyphenols from Caryota urens L:A Molecular Docking Analysis. Research J. Pharm. And Tech 2020; 13(9): 4269-4273.
10. Suby Mary Samuel, K Pramod, E N Bijin, K C Ajithkumar, U S Jijith. Herbal Remnedies for Rheumatoid Arthritis. Res. J. Pharmacognosy & Phytochem. 2016; 8(1): 32-36.
11. Chander Hass, Parveen Kumar, Dheeraj Rajak, S.K. Jain, Manish M. Evaluation of Analgesic and Anti-inflammatory Activity of Bark of Neolamarckia cadamba in Rodents. Research J. Pharm. And Tech. 2010; 3(4): 1178-1184.