Aim: The fundamental objective and goal of the current research is to determine the effectiveness of Cassia tora in the treatment of gastric ulcers in order to produce an anti-ulcer medication of natural origin. Method: The plant material was successively extracted by the Soxhlet extraction technique with chloroform, methanol, butanol and water. The antioxidant activity of the plant extracts and the standard drugs were based on consideration of the radical scavenging influence of the stable "1,1-diphenyl-2-picrylhydrazyl" (DPPH) free radical action and hydrogen peroxide process. Two models, and non-steroidal anti-inflammatory induced ulcer and pyloric ligation, were analysed for methanolic extract of Cassia tora for its antiulcer activity. Results: Among all the extract, the percent of DPPH inhibition at 200 µg mL-1 for MECT extracts (Cassia tora methanolic extract) was 58.67±1.95. The overall scavenging potential for the H2O2 process was 68.23±0.19 at 200 µg mL-1 by MECT extract. Hence MECT extract was undertaken for the antiulcer property. Compared with control, there was a significant (p<0.05) decrease in free acidity, gastric volume, and total acidity in the extract-treated classes and ranitidine (standard). The Cassia tora methanolic extract demonstrated significant (p<0.05) inhibition activity, i.e. 59.42 and 69.59 percent at 500 mg mL-1 with the PL (Pylorus ligation) and NSAID (Non-steroidal anti-inflammatory drugs) process respectively. Conclusion: The findings of present study provide the scientific evidence to Cassia tora as a strong antiulcer and antioxidant agent.
Cite this article:
Lalchand D. Devhare, Niharika Gokhale. Antioxidant and Antiulcer property of different solvent extracts of Cassia tora Linn. Research Journal of Pharmacy and Technology. 2022; 15(3):1109-3. doi: 10.52711/0974-360X.2022.00185
Lalchand D. Devhare, Niharika Gokhale. Antioxidant and Antiulcer property of different solvent extracts of Cassia tora Linn. Research Journal of Pharmacy and Technology. 2022; 15(3):1109-3. doi: 10.52711/0974-360X.2022.00185 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-3-28
1. Kuna L, Jakab J, Smolic R, Raguz-Lucic N, Vcev A, Smolic M. Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options. J Clin Med. 2019; 8(2): 179.
2. Højgaard L, Mertz Nielsen A, Rune SJ. Peptic ulcer pathophysiology: acid, bicarbonate, and mucosal function. Scand J Gastroenterol Suppl. 1996; 216: 10-5.
3. Sairam K, Priyambada S, Aryya NC, Goel RK. Gastroduodenal ulcer protective activity of Asparagus racemosus: An experimental, biochemical and histological study. Ethnopharmacol. 2003; 86: 1–10.
4. Anoop A, Jegadeesan M. Biochemical studies on the antiulcerogenic potential of Hemidesmus indicus R. Br. Var. J Ethnopharmacol 2003; 84: 149–156.
5. Sharifi-Rad M, Fokou PVT, Sharopov F, et al. Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion. Molecules. 2018; 23(7): 1751.
6. Ingle AM, Ladke AV, Ranaware PS, Rao SH, Damle MC. Evaluation of the Antibacterial Activity of Methanolic and Aqueous Extract for the Seeds of Cassia tora. Research J. Pharmacognosy and Phytochemistry. 2012; 4(5): 240-243.
7. Mohite S, Shah R, Patel N. Antimicrobial Activity of Leaves extracts of Cassia tora. Res. J. Pharma. Dosage Forms and Tech. 2018; 10(1): 10-12.
8. Kumar RS, Narasingappa RB, Joshi CG, Girish TK, Prasada Rao UJ, Danagoudar A. Evaluation of Cassia tora Linn. against Oxidative Stress-induced DNA and Cell Membrane Damage. J Pharm Bioallied Sci. 2017; 9(1): 33-43.
9. Sahu J, Koley KM, Sahu BD. Attribution of antibacterial and antioxidant activity of Cassia tora extract toward its growth promoting effect in broiler birds. Vet World. 2017; 10(2): 221-226.
10. Muthukumaran P, Shanmuganathan P, Malathi C. In Vitro Antioxidant Evaluation of Mimosa pudica. Asian J Pharm Res. 2011; 1(2): 44-46.
11. Valli G, Jeyalakshmi M. Preliminary Phytochemical and Antioxidant Study of Odina woodier Leaf Extract. Asian J Pharm Res. 2012; 2(4): 153-155.
12. Roy SP, Niranjan CM, Jyothi TM, Shankrayya MM, Vishawanath KM et al. Antiulcer and anti-inflammatory activity of aerial parts Enicostemma littorale blume. Pharmacology. 2010; 2: 369-373.
13. Manikandan A, Victor Arokia Doss D. Antiulcer Activity of 50% Hydroethanolic Leaf Extract of Ruellia tuberosa l. and Dipteracanthus patulus (Jaca) On Pylorus Ligated Gastric Ulcer Model. Research J. Pharmacognosy and Phytochemistry. 2009; 1(3): 198-200.
14. Manimekalai P, Maheshwari P, Velmurugan R, Gurumoorthy M, Hansraj Kumar S, Vijayakumar G. Gastro Protective effect of Standardized Ethanolic leaf extract of Indigofera tinctoriao on experimental Gastric Ulcers in Rats. Research J Pharm and Tech. 2018; 11(2):527-531.
15. Panda PK, Patro VJ, Mohanty PK, Panda SK, Jaliwalla YA. Antiulcer Activity of Cassia mimosoides Bark Extract and Its Comparison with Ranitidine in Shay Rat. Research J. Pharmacognosy and Phytochemistry. 2011; 3(4): 166-168.
16. Desai JK, Goyal RK, Parmar NS. Gastric and duodenal anti-ulcer activity of SKF 38393, a dopamine D1- receptor agonist in rats. J. Pharm. Pharmacol. 1995; 47: 734-738.
17. Takagi, K., S. Okabe and R. Saziki. A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. Jpn. J. Pharmacol. 1969; 19: 418-426.
18. Antonisamy P, Dhanasekaran M, Kim HR, Jo SG, Agastian P, Kwon KB. Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models. Saudi J Biol Sci. 2017; 24(8): 1933-1938.
19. Wu CH, Yen GC. Antigenotoxic properties of Cassia tea (Cassia tora L.): mechanism of action and the influence of roasting process. Life Sci. 2004; 76(1): 85-101.
20. Kumar V, Singh R, Mahdi F, Mahdi AA, Singh RK. Experimental Validation of Antidiabetic and Antioxidant Potential of Cassia tora (L.): An Indigenous Medicinal Plant. Indian J Clin Biochem. 2017; 32(3): 323-328.
21. Dighe NS, Pattan SR, Nirmal SA, Dhasade VV, Dake SG, Shelar MU et al. A Review on Phytochemical and Pharmacological Profile of Cassia tora Linn. Research J. Pharmacognosy and Phytochemistry. 2009; 1(3): 173-176.
22. Chavan RT, Kalane VJ, Deshmukh VL. In vitro antimicrobial activity of Cassia tora L. stem. Curr. Bot. 2011; 2: 8-9.
23. Malathi R, Ahamed John S, Cholarajan A. Antioxidant Activity of Extract from the Leaves of Tylophora asthmatica. Asian J Res Pharm Sci. 2012; 2(2): 80-82.
24. Yuan Y, Padol IT, Hunt RH. Peptic ulcer disease today. Gastroenterol Hepatol. 2006; 3: 80–89.
25. Galunska B, Marazova K, Yankova T. Effects of paracetamol and propacetamol on gastric mucosal damage and gastric lipid peroxidation caused by acetyl salicylic acid (ASA) in rats. Pharamcol Res. 2002; 46: 141–148.
26. Rathnakumar K, Jaikumar S, Sengottuvelu S. Antiulcer Activity of Euphorbia hirta against Experimentally Induced Ulcer in Rats. Asian J Pharm Res. 2013; 3(3): 122-124.
27. Demir SM, Yilmaz M, Koseoglu N, Aslan AD, Aydin A. Role of free radicals in peptic ulcer and gastritis. Turk J Gastroenterol. 2003; 14: 39-43.