Author(s): Omar Yahya Alshargi, Samah Mukhlef Alzaid, Zainab ibrahim Albahouth, Ammar Ali Jaber, Bodoor Saud Al-Dosari

Email(s): omar.alshargi2@gmail.com , smalzaid@moh.gov.sa , ph.zozo@windowslive.com , ammarali20142015@gmail.com , bsaldosari@kau.edu.sa

DOI: 10.52711/0974-360X.2022.00163   

Address: Omar Yahya Alshargi1*, Samah Mukhlef Alzaid2, Zainab ibrahim Albahouth3, Ammar Ali Jaber4, Bodoor Saud Al-Dosari5
1College of Pharmacy, Riyadh Elm University, Riyadh 11681, Saudi Arabia.
2Clinical Pharmacy Department, Gurayat General Hospital, Gurayat – Husydah - 3407, 77455, Saudi Arabia.
3Clinical Pharmacy Department, Ministry of Health, Asalam, Riyadh, Saudi Arabia.
4Department of Clinical Pharmacy and Pharmacotherapeutics, Dubai Pharmacy College for Girls, Dubai, United Arab Emirates.
5Pharmacy Department, King Abdulaziz University Hospital, Jeddah 21589, Kingdom of Saudi Arabia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 3,     Year - 2022


ABSTRACT:
Background: Pharmacometabonomics is a new approach developed in the delivery of personalized medicine to improve optimal drug efficacy and safety to patients. We summarized the literature regarding the application of pharmacometabonomics in neurology. Methods: We conducted a systematic search of the literature using Medline via PubMed, from the inception of the database to April 2020. Other articles were searched from the manual search of the included articles. Other information was retrieved from Google Scholar. Data from the included articles were reviewed and summarized based on neurological disorder/drug, experiment employed and clinical application. Results: The search of the literature generated 258 articles, of which 10 were included for review based on the selection criteria. The review of the literature demonstrates that pharmacometabonomics has been used in the prediction of drug efficacy, adverse drug events, and metabolisms in neurological toxicity, schizophrenia, multiple sclerosis, major depressive and bipolar disorders. The commonly employed pharmacometabonomics methods were liquid chromatography coupled with electrochemical coulometric, mass spectrometry, nuclear magnetic resonance, and gas chromatography. Conclusion: Earlier evidence has demonstrated that pharmacometabonomics has the potential of improving drug safety in neurology, through the delivery of personalized medicine. Therefore, more studies are needed to explore its clinical applications in other areas of neurology for optimal outcomes.


Cite this article:
Omar Yahya Alshargi, Samah Mukhlef Alzaid, Zainab ibrahim Albahouth, Ammar Ali Jaber, Bodoor Saud Al-Dosari. Clinical Applications of Pharmacometabonomics in Neurology: Current Status, Future Perspectives and Challenges. Research Journal of Pharmacy and Technology. 2022; 15(3):976-0. doi: 10.52711/0974-360X.2022.00163

Cite(Electronic):
Omar Yahya Alshargi, Samah Mukhlef Alzaid, Zainab ibrahim Albahouth, Ammar Ali Jaber, Bodoor Saud Al-Dosari. Clinical Applications of Pharmacometabonomics in Neurology: Current Status, Future Perspectives and Challenges. Research Journal of Pharmacy and Technology. 2022; 15(3):976-0. doi: 10.52711/0974-360X.2022.00163   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-3-6


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