Author(s): Pankaj Kumar, Abhishek Kumar, Jean Sandra Pinto, Sachin A. Kumbar, Nanditha Bhat, Prashant Nayak

Email(s): abhi12bunty@gmail.com

DOI: 10.52711/0974-360X.2022.00304   

Address: Pankaj Kumar1, Abhishek Kumar1*, Jean Sandra Pinto1, Sachin A. Kumbar1, Nanditha Bhat1, Prashant Nayak2
1Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangaluru, Karnataka, India.
2Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangaluru, Karnataka, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 4,     Year - 2022


ABSTRACT:
The a,ß unsaturated ketone 3-(2,4-dimethyl-1H-pyrrol-3-yl)-1-phenylprop-2-en-1-onederivatives were treated with benzene-1,2-diamine to obtain 2-(2,4-dimethyl-1H-pyrrol-3-yl)-4-phenyl-2,3-dihydro-1H-benzo[b][1,4]diazepine derivatives. These synthesized compound were characterized by IR, 1H NMR, and mass spectroscopy. These synthesized molecules were evaluated for invitro antimicrobial activity. All The synthesized compounds, showed potent anti-microbial activity as compare to reference drug. In these study the synthesized were docked with Type IIA topoisomerases 2XCT using glide dock program and binding affinity were predicted for the synthesized compounds. The compound AP8 and AP9 have shown more active as per binding energy.


Cite this article:
Pankaj Kumar, Abhishek Kumar, Jean Sandra Pinto, Sachin A. Kumbar, Nanditha Bhat, Prashant Nayak. Synthesis and antimicrobial evaluation of some novel 1,5 benzodiazepine derivatives derived from pyrrolyl chalcones. Research Journal of Pharmacy and Technology. 2022; 15(4):1811-4. doi: 10.52711/0974-360X.2022.00304

Cite(Electronic):
Pankaj Kumar, Abhishek Kumar, Jean Sandra Pinto, Sachin A. Kumbar, Nanditha Bhat, Prashant Nayak. Synthesis and antimicrobial evaluation of some novel 1,5 benzodiazepine derivatives derived from pyrrolyl chalcones. Research Journal of Pharmacy and Technology. 2022; 15(4):1811-4. doi: 10.52711/0974-360X.2022.00304   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-4-70


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