Author(s):
Vaibhavi Patel, Priya Mehta, Kunjan Kikani, Girish K. Goswami
Email(s):
vaibhavipatel1521@gmail.com , priyamehta3989@gmail.com , kunjankikani@gmail.com , girishkgoswami@gmail.com
DOI:
10.52711/0974-360X.2022.00330 
Address:
Vaibhavi Patel¹, Priya Mehta2, Kunjan Kikani3, Girish K. Goswami4
1Dept. of Microbiology and Biotechnology, C U Shah Institute of Life Sciences, Wadhwan City, Surendranagar, Gujarat, India.
2Dept. of PGDMLT, Mehsana Urban Institute of Sciences, Ganpat University, Mehsana, Gujarat, India.
3Professor, Microbiology Department, C. U. Shah Medical College, Surendranagar, Gujarat, India.
4Project Director, GUJCOST, DST, Gujarat, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 5,
Year - 2022
ABSTRACT:
Klebsiella, a gram-negative, rod-shaped bacteria that can cause different types of infections like enteritis, meningitis, urinary tract infections, bacteraemia, septicaemia etc. In humans Klebsiella pneumoniae is among the foremost common bacteria combatted by medical practitioners worldwide which are often resistant to several antibiotics and doesn’t get cured easily. To study the antibiotic resistance among patients, total 856 clinical isolates were collected from different clinical specimens of patients admitted in different wards of C. U. Shah Hospital, Surendranagar, Gujarat, India for a period of 3 years (2016 to 2018). The specimens were processed at Department of Microbiology, C. U. Shah Hospital, Surendranagar, with an objective to study the antibiotic resistance pattern of the Klebsiella Species. Antimicrobial resistance not only increases the healthcare costs, but it is also linked with the severity and death rates from certain infections.
Cite this article:
Vaibhavi Patel, Priya Mehta, Kunjan Kikani, Girish K. Goswami. Antibiotic Sensitivity Pattern of Clinically Isolated Klebsiella Species in C. U. Shah Hospital, Surendranagar. Research Journal of Pharmacy and Technology. 2022; 15(5):1989-4. doi: 10.52711/0974-360X.2022.00330
Cite(Electronic):
Vaibhavi Patel, Priya Mehta, Kunjan Kikani, Girish K. Goswami. Antibiotic Sensitivity Pattern of Clinically Isolated Klebsiella Species in C. U. Shah Hospital, Surendranagar. Research Journal of Pharmacy and Technology. 2022; 15(5):1989-4. doi: 10.52711/0974-360X.2022.00330 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-5-12
REFERENCES:
1. Pathak S, Ingole K, Gawande R. (2018) Antibiotic sensitivity pattern of Klebsiella species isolated from various clinical samples, International Journal of Scientific Research. 7(1):21-22 doi: 10.36106/IJSR
2. Babakhani S, Shokri S, Reza M, Kazem M. (2014) Comparison frequency and Determination antibiotic resistance pattern of Klebsiella SPP. isolated from Nosocomial infection in Khorramabad Shohadaye Ashayer hospital. Bull. Env. Pharmacol. Life Sci.3:149-154
3. Akram M, Shahid M, Khan A. (2007) Etiology and antibiotic resistance patterns of community acquired urinary tract infections in JNMC Hospital, Aligarh, India. Annals of Clinical Microbiology and Antimicrobials. 6:4 doi.org/10.1186/1476-0711-6-4
4. Sreeja. M.K, Gowrishankar N.L, Adisha. S, Divya. K.C. Antibiotic Resistance-Reasons and the Most Common Resistant Pathogens – A Review. Research J. Pharm. and Tech. 2017; 10(6): 1886-1890. doi: 10.5958/0974-360X.2017.00331.6
5. Sikarwar A, Batra H. (2011) Prevalence of antimicrobial drug resistance of Klebsiella pneumonia in India. International Journal of Bioscience, Biochemistry and Bioinformatics. 1(3):211-215 doi: 10.7763/IJBBB. 2011.V1.38
6. Chakraborty S, Kaniz M, Sarker P, Zahangir M, Ismail M, Abu S. (2016) Prevalence, antibiotic susceptibility profiles and ESBL production in Klebsiella pneumoniae and Klebsiella oxytoca among hospitalized patients. Periodicum Biologorum. 118(1):53-58. doi: 10.18054/pb.2016.118.1.3160
7. Sara H. Mohamed, Mary S. Khalil, Mona I. Mabrouk, Mahmoud S.M. Mohamed. Prevalence of antibiotic resistance and biofilm formation in Klebsiella pneumoniae carrying fimbrial genes in Egypt. Research J. Pharm. and Tech. 2020; 13(7): 3051-3058. doi: 10.5958/0974-360X.2020.00542.9
8. Kishnani Khushboo, Bhandari Saloni, Rathore Kamal Singh. A Briefing of a Global Crisis: Antibiotic Resistance. Asian J. Res. Pharm. Sci. 2020; 10(4):264-272. doi: 10.5958/2231-5659.2020.00047.8
9. Bezlon G., Shanmugha Sundhar D., Rinu Edwin R.E. Design and Stabilization of Natural Antibacterial Compound Allicin against Methicillin-Resistant Staphylococcus Aureus for Treatment as a Novel Antibiotic. Research J. Engineering and Tech. 4(4): Oct.-Dec., 2013 page 179-181.
10. CLSI Performance standards for antimicrobial susceptibility testing. 28th ed. CLSI supplement M100. Wayne, PA: Clinical and Laboratory Standards Institute. (2018)
11. Chi square- Mathbeans Project. David, Jim Ryan. National Science Foundation DUE-9950473.
12. Step-by-step approach for development and implementation of hospital antibiotic policy and standard treatment guidelines- World Health Organization, Regional Office for South-East Asia, Indraprastha Estate, Mahatma Gandhi Marg, New Delhi-110 002, India
13. Sachin H. Rohane, Ashlesha G. Makwana. A Review on Hydrazone, the fascinating field of investigation in medicinal chemistry. Asian J. Research Chem. 2017; 10(4):417-430. doi: 10.5958/0974-4150.2017.00070.0
14. Saha A. (2019) Pattern of antimicrobial susceptibility of Klebsiella pneumoniae isolated from urinary samples in urinary track infection in a Tertiary Care Hospital, Kishanganj, and Bihar. MGM Medical College and LSK Hospital, Bihar, India. IJCMR. 6(12): L25-L28. doi.org/10.21276/ijcmr.2019.6.12.42
15. Wani R, Ahmed N, Irshad M, Ashraf M, Bashir A. (2019) Clinicobacteriological profile, antibiotic sensitivity patterns and mortality of neonatal sepsis in a tertiary care hospital in Kashmir, Jammu and Kashmir, India. 6(3):917-921 doi:10.18203/2349-3291.ijcp20191994
16. Dr. Bhupendra Kumar. (2019) Detection and antibiogram of extended spectrum beta lactamase (esbl) producing klebsiella pneumoniae in south–east Rajasthan, Government Medical College, Kota (Rajasthan). Wipmr. 5(9):130-137
17. Rizwan M, Akhtar M, Kalam A, Singh K, Hakim A. (2018) Escherichia coli and Klebsiella pneumoniae sensitivity/resistance pattern towards antimicrobial agents in primary and simple urinary tract infection patients visiting university hospital of jamia hamdard New Delhi, India. Epub . 68(7):415-420. doi: 10.1055/a-0576-0079
18. Aishwarya J. Ramalingam. History of Antibiotics and Evolution of Resistance. Research J. Pharm. and Tech. 8(12): Dec., 2015; Page 1719-1724. doi: 10.5958/0974-360X.2015.00309.1
19. Ashish Vyas, Karamjeet Singh, Gaurav Kumar. Prevalence and drug resistance among bacteria of urinary tract infections in females in Punjab, India. Research J. Pharm. and Tech. 2017; 10(2): 575-578. doi: 10.5958/0974-360X.2017.00114.7
20. Nanda Anima, Dhamodharan S, Nayak B. K. Antibiotic Resistance Pattern Exhibited by Esbl (Extended Spectrum β-Lactamases) in Multidrug Resistant Strains, Escherichia coli. Research J. Pharm. and Tech 2017; 10(11): 3705-3708. doi: 10.5958/0974-360X.2017.00672.2
21. Srinivasan S, Saldanha S, Abhyankar S, Modi N, Patil A, Vartak A. (2017) Antibiotic sensitivity pattern of Klebsiella species in burn wounds at Bai Jerbai Wadia hospital for children, Mumbai, India-a 21year study. Int J Burn Trauma. 7(5):64-71.
22. Rajesh KS, Honey VS, Ullas Prakash D’souza, Ragava Sharma, Bharath Raj KC. Study of Antibiotic resistance pattern in uropathogens at a Tertiary Care Hospital. Research J. Pharm. and Tech 2020; 13(3): 1253-1256. doi: 10.5958/0974-360X.2020.00231.0
23. Woldu M. (2016) Klebsiella pneumoniae and Its Growing Concern in Healthcare Settings. Addis Ababa University. Clin Exp Pharmacol. 5(6). doi: 10.4172/2161-1459.1000199
24. Niveditha, Srikanth, Rathai Rajagopalan, Shivamurthy M.C. A Retrospective Evaluation of Compliance in Various Surgical Departments with Respect to Surgical Antibiotic Prophylaxis in a Tertiary Care Hospital. Research J. Pharm. and Tech 6(7): July 2013; Page 749-752.