Author(s): Dileep Singh Baghel, Saurabh Singh, Narendra Kumar Pandey, Bimlesh Kumar, Amit Mittal, Anand Kumar Chaudhary, Anu Mittal, Amrik Singh

Email(s): bimlesh.12474@lpu.co.in , dileep.15210@lpu.co.in , amit.13145@lpu.co.in

DOI: 10.52711/0974-360X.2022.00334   

Address: Dileep Singh Baghel1, Saurabh Singh1, Narendra Kumar Pandey1, Bimlesh Kumar1, Amit Mittal1*, Anand Kumar Chaudhary2, Anu Mittal3, Amrik Singh4
1School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India.
2Department of Rasa Shastra and Bhaishjya Kalpana (Ayurvedic Pharmaceutics), Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India.
3Department of Chemistry, Guru Nanak Dev University Collage, Patti, Tran Taran, Punjab, India.
4School of Hotel Management and Tourism, Lovely Professional University, Punjab, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 5,     Year - 2022


ABSTRACT:
Background: Urolithiasis (Mutrakricchra) is an age-old disorder which has multi-factorial etiological as well as associated with re-occurrence. It is standout among the most troubling disorders related to urinary tract. Acharya Sushruta, a pioneer in the art of surgery, described the root causes and management of urolithiasis (Mutrakricchra). In present day restorative practice, a lot of the management/treatment choices are available which begins from the utilization of uresis-elevating specialist to dietary or nourishing enhancement consumption. Amalgamating the Ayurvedic principle/concept with current medicinal practice is a promising methodology used for the management of urolithiasis (Mutrakricchra) now a days. Objective: To prepare apamarg kshar and evaluate its potential against Urolithiasis (Mutrakrichra) by In-vitro technique. Materials and Methods: Apamarg kshar were prepared as per the methodology mentioned in Rasatarangni and the prepared Kshar is compressed in tablet dosage form. Various parameters of apmarg kshar tablets were evaluated. Results: Physicochemical and stability studies have not shown any remarkable variations with prepared tablet dosage form. In-vitro studies shows that 82 % of crystal inhibition at 550 µg/ml. Conclusion: The prepared tablet dosage form of Apamarg Kshar does not have remarkable variation during physicochemical and stability studies. The developed dosage form produces promising result in vitro against Urolithiasis (Mutrakrichra).


Cite this article:
Dileep Singh Baghel, Saurabh Singh, Narendra Kumar Pandey, Bimlesh Kumar, Amit Mittal, Anand Kumar Chaudhary, Anu Mittal, Amrik Singh. Preparation of Apamarg Kshar Tablet and Assessment of In Vitro Potential against Urolithiasis (Mutrakrichra). Research Journal of Pharmacy and Technology. 2022; 15(5):2017-7. doi: 10.52711/0974-360X.2022.00334

Cite(Electronic):
Dileep Singh Baghel, Saurabh Singh, Narendra Kumar Pandey, Bimlesh Kumar, Amit Mittal, Anand Kumar Chaudhary, Anu Mittal, Amrik Singh. Preparation of Apamarg Kshar Tablet and Assessment of In Vitro Potential against Urolithiasis (Mutrakrichra). Research Journal of Pharmacy and Technology. 2022; 15(5):2017-7. doi: 10.52711/0974-360X.2022.00334   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-5-16


REFERENCE:
1.    Dileep Singh Baghel, Saurabh Singh, Amit Bhatia, Tamilvanan S, Amalgamation of Ayurvedic concept with modern medical practice to manage kideny stone (Urolithasis): An abbreviated review. Indian Drugs, 2018. 55 (11): p. 7-18.
2.    Sastri, K., Charak Samhita by Agnivesa. Chaukhambha Bharti Academy, Varansi, 2013.
3.    Yadavji, A.T., Sushruta Samhita by Sushruta. Krishnada Academy, Varanasi, 1980.
4.    Shanmugapriya, J. and S. Kumar, A prospective study on quality of life in patients with urinary calculi. Asian Journal of Pharmaceutical and Clinical Research, 2017: p. 191-193.
5.    Chunekar, K.C. and G. Pandey, Bhavprakash nighantu. Chukhamba bharti academy, Varanasi, 2004.
6.    Shubhashree M. N., D.S.H., Giri S.K., Triveni D.P., Sulochana Bhat, Ayurvedic Management of Paediatric Urolithiasis (Mutrashmari): A Case Report. Research Journal of Pharmacy and Technology, 2017. 8(1): p. 77-80.
7.    Tripathi, K., Essentials of medical pharmacology . JP Medical Ltd. London. 2013.
8.    Satoskar, R.S., N. Rege, and S. Bhandarkar, Pharmacology and Pharmacotherapeutics-E-Book . Elsevier Health Sciences. 2015.
9.    Stamatelou, Kiriaki K, Francis, Mildred E Jones, Camille A Nyberg Jr, Leroy M Curhan, Gary C, Time trends in reported prevalence of kidney stones in the United States: 1976–1994. Kidney international, 2003. 63(5): p. 1817-1823.
10.    Asplin, J Parks, J Lingeman, J Kahnoski, R Mardis, H Lacey, S Goldfarb, D Grasso, M Coe, F, Supersaturation and stone composition in a network of dispersed treatment sites. The Journal of urology, 1998. 159(6): p. 1821-1825.
11.    Dutta, Koushik Nandan Chetia, Purbajit Lahkar, Sunita Das, Sumit, Herbal plants used as diuretics: a comprehensive review. Journal of Pharmaceutical, Chemical and Biological Sciences, 2014. 2(1): p. 27-32.
12.    Manjula, K Pazhanichami, K Rajendran, K Kumaran, S Eevera, T, Herbal remedy for urinary stones: Vegetables and human health. Scientific publishers, 2015: p. 454-468.
13.    Sakshi Sabharwal, Nitika Anand, Simranjeet Kaur, Vibhu Khanna, Dileep Singh Baghel, Saurabh Singh, Amit Mittal, An Overview On: Apamarga Kshara. International Journal of Emerging Technologies and Innovative Research 2018. 5(10): p. 301-307.
14.    Gupta, SS Verma, SCL Ram, AK Tripathi, RM, Diuretic effect of the saponin of Achyranthes aspera (Apamarga). Indian Journal of Pharmacology, 1972. 4(4): p. 208.
15.    Prasad, P. and P. Subhaktha, Apamarga (Achyranthes aspera Linn.) A Medico-Historical Review. Bull. Ind. Hist. Med, 2001. 31: p. 11-24.
16.    Sharma, S., Rasatarangini. 11th ed., Motilal Banarsidas, Delhi, India, 2006.
17.    Vidyanath, R., A Hand Book of Astanga Sangraha. Chaukhamba Surbharati Prahashan, Varanasi, India, 2006.
18.    Sharma, P., Shodhala Nighantu. Chaukamba Orientalia, Varnasi, 1978.
19.    Shaligrama, S., Shaligrama nighantu. Khemaraj Shri Krishna das Prakashan, Mumbbi, 2002.
20.    Kamat, S., Dhanvantari nighantu. Chaukhambha Sanskrit Pratisthan, Delhi, 2002.
21.    Pandey, G., Madanpal Nighantu. Varanasi: Chowkhambha orientalia, 2012.
22.    Bapalal, V., Nighantu Adarsh Chaukhambha Bharati Academy, Varanasi, 1999.
23.    Sharma, P.V. and G.P. Sharma, Kaiyadeva nighantu. Chaukhambha Orientalia, Varanasi, 1979.
24.    Tripathi, I. and V. Dwivedi, Raj Nighantu. Chaukhamba Krishnadas Academy, Varanasi, 2006.
25.    Sharma, P., Hrdaya Dipaka Nighantu and Siddhamantra. Chaukhambha Amarabharati Prakashan, Varanasi, 1977.
26.    PV Sharma, Priya nighantu. Chaukhamba Surabharati Prakashana, Varanasi, 2004.
27.    Kashiraj Sharma, N.T., Saushrut Nighantu. Mahendra Sanskrit University, Nepal, 2001.
28.    Anonymous, Ashtanga Nighantu, e Nighantu. Collection of Ayurvedic Lexicons, CCRAS, New Delhi, 2012.
29.    Anonymous, Madanadi Nighantu, e Nighantu. Collection of Ayurvedic Lexicons, CCRAS, New Delhi, 2012.
30.    Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Anand Kumar Chaudhary, Amit Bhatia, Shruti Chopra, Formulation, Evaluation and Assessment of In Vitro Potential of Gokshur Ghan Tablet against Urolithiasis (Mutrakrichra). Research Journal of Pharmacy and Technology, 2021. 14(4): p. 1945-1952. https://www.doi.org/10.52711/0974-360X.2021.00344
31.    Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Rajesh Kumar, Anand Kumar Chaudhary, Amit Bhatia, Formulation and Evaluation of In vitro Potential of Punarnava ghan Tablet against Urolithiasis (Mutrakrichra). Research Journal of Pharmacy and Technology, 2021. 14(3): p. 1469-1476. https://www.doi.org/10.5958/0974-360X.2021.00261.4
32.    Aman Sharma, Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Standardization and Comparative Study of Guduchi Churna, Guduchi Ghan Vati and Guduchi Satwa. Think India Journal, 2019. 22(17): p. 509-519.
33.    Rohit Thakkar, Dileep Singh Baghel, and Saurabh Singh, Physicochemical screening of Godanti Bhasma: An effort to pharmaceutical standardisation. J Pharm Res, 2017. 11: p. 887-94.
34.    Shiv Kumar, Shruti Chopra, Amit Mittal. Saurabh Singh, Jaswinder Kaur, Dileep Singh Baghel, Amit Bhatia, Comprehensive Review on Tablet Processing and Evaluation. Journal of Emerging Technologies and Innovative Research 2018. 5(12): p. 719-732.
35.    Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Anand Kumar Chaudhary, Amit Bhatia, Shruti Chopra, IN-Vitro Potential of Sphatika Tablet in the Management of Urolithiasis (Mutrakrichra). Plant Archives, 2020. 20(2): p. 1210-1216.
36.    Swati Sharma, Dileep Singh Baghel, Saurabh Singh, Sachin Kumar Singh, Dosage form development and preliminary physicochemical characterization of Trikantakadi Kvatha. Asian Journal of Pharmaceutical and Clinical Research, 2017(Special Issue (September)): p. 52-56. http://dx.doi.org/10.22159/ajpcr.2017.v10s3.21336
37.    DL Pavia, G.L., GS Kriz, JA Vyvyan, Introduction to spectroscopy. 2014: Nelson Education.
38.    Anamika Gautam, Saurabh Singh, Dileep Singh Baghel, Gurmeet Singh, Bimlesh Kumar, Sachin Kumar Singh, Monica Gulati, Narendra Kumar Pandey, Protective effect of Polyherbal syrup and tablet against Ethylene glycol induced Urolithiasis in rats. Research Journal of Pharmacy and Technology, 2021. 14(1): p. 249-253. https://www.doi.org/10.5958/0974-360X.2021.00044.5
39.    Swati Sharma, Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Bimlesh Kumar, Pranav Kumar Prabhakar, Anand Kumar Chaudhary, Polyherbal Formulation Development and Assessment of its Potential against Urolithiasis (Mutrakricchra) by In-Vitro Technique. Research Journal of Pharmacy and Technology, 2021. 14(4): p. 1982-1988. https://www.doi.org/10.52711/0974-360X.2021.00351
40.    Chhaya Kumari, Dileep Singh Baghel, Bimlesh Kumar, Saurabh Singh, Formulation of Hajral yahud pishti and its in vitro antiurolithiatic effect. Asian Journal of Pharmaceutical and Clinical Research, 2018. 11(2): p. 370-378. http://dx.doi.org/10.22159/ajpcr.2018.v11i2.23385

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