Author(s):
Dhruva Bhat, Mukunda N, Lokesh L V
Email(s):
drmukundagm@gmail.com
DOI:
10.52711/0974-360X.2022.00430 
Address:
Dhruva Bhat1, Mukunda N1*, Lokesh L V2
1Department of Pharmacology, M S Ramaiah Medical College, Bengaluru – 560054, Karnataka, India.
2Department of Gastroenterology, M S Ramaiah Medical College, Bengaluru – 560054, Karnataka, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 6,
Year - 2022
ABSTRACT:
Aim: The aim of this study was to assess the effect of acotiamide and esomeprazole combination therapy in improving Functional Dyspepsia (FD) - related symptoms in comparison with acotiamide or esomeprazole monotherapy. Materials and Methods: This was a prospective observational study conducted in patients attending outpatient department of Gastroenterology, M S Ramaiah Hospitals and diagnosed to have functional dyspepsia based on Rome IV criteria. Group 1 received acotiamide, group 2 received esomeprazole and group 3 received acotiamide plus esomeprazole combination therapy for a period of 6 weeks. The efficacy of treatment was assessed using symptom assessment scale. We also assessed the responder rate, resolution rate and treatment emergent adverse events. Results: In this study a total of 52 patients completed the study in each group. There was a statistically significant improvement in symptom assessment scale - Epigastric pain syndrome (EPS), Postprandial distress syndrome (PDS), Total Abdominal Symptom (TAS) scores from baseline to 6 weeks in all the 3 treatment groups (p <0.001). Combination therapy (group 3) showed maximum reduction from baseline to week 6 (mean differences of 11.07, 3.53 and 5.65 in TAS, EPS, PDS scores respectively). The common adverse events reported were fever, headache, diarrhoea and nasopharyngitis. Conclusion: Combination therapy of acotiamide with esomeprazole was effective in reducing symptom scores at the end of 6 weeks in patients with FD as compared to monotherapy with either of the drugs.
Cite this article:
Dhruva Bhat, Mukunda N, Lokesh L V. Effect of Acotiamide and Esomeprazole combination therapy on Functional Dyspepsia symptoms in comparison with Acotiamide or Esomeprazole Monotherapy: A Prospective Observational Study. Research Journal of Pharmacy and Technology. 2022; 15(6):2571-6. doi: 10.52711/0974-360X.2022.00430
Cite(Electronic):
Dhruva Bhat, Mukunda N, Lokesh L V. Effect of Acotiamide and Esomeprazole combination therapy on Functional Dyspepsia symptoms in comparison with Acotiamide or Esomeprazole Monotherapy: A Prospective Observational Study. Research Journal of Pharmacy and Technology. 2022; 15(6):2571-6. doi: 10.52711/0974-360X.2022.00430 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-6-34
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