Author(s): Shafira Kurnia, Chiquita Prahasanti, Onge Victoria Hendro, Yokthan Ofier Siki, Wibi Riawan, Lambang Bargowo


DOI: 10.52711/0974-360X.2022.00442   

Address: Shafira Kurnia1, Chiquita Prahasanti1*, Onge Victoria Hendro2, Yokthan Ofier Siki2, Wibi Riawan3, Lambang Bargowo1
1Lecturer, Department of Periodontology, Faculty of Dental Medicine, Airlangga University, Surabaya – Indonesia.
2Resident, Graduate Program in Periodontology, Faculty of Dental Medicine, Airlangga University, Surabaya – Indonesia.
3Department of Biomolecular Biochemistry, Faculty of Medicine, Brawijaya University, Malang – Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022

Background and Aim: The current goal of periodontal therapy is to achieve periodontal regeneration. Important factor for periodontal regeneration is to promote bone formation, nowadays used bone replacement. The used of xenograft materials as gold standard for periodontal tissue regeneration using type I collagen bone graft has been widely developed. The main organic component in fish scales is type I fibril collagen, which are same as with component in bones. Specific markers of bone formation are the expression of osteoblast, osteoclast, osteoprotegerin (OPG), and receptor activator of nuclear factor ?B ligands (RANKL). The purpose of this study is to assess the expression of OPG and RANKL after application of extract collagen from gourami (Osphronemus gouramy) scales. Materials and Methods: Thirty-two experimental 3-month-old male Wistar albino rats (150g and 200g) were randomly divided into four groups: 7-day control group, 7-day fish collagen group, 14-day control group and 14-day fish collagen group. The sockets were filled with blood (control group), whereas 10 mg to 30 mg extract collagen was added until the sockets were fully occupied (treatment group). Results: The ANOVA test showed a significance level of 0.000 (p <0.05). Conclusion: Expression of OPG enhanced and expression of RANKL lowered after application of type I collagen from gourami scales, accelerating osteogenesis.

Cite this article:
Shafira Kurnia, Chiquita Prahasanti, Onge Victoria Hendro, Yokthan Ofier Siki, Wibi Riawan, Lambang Bargowo. OPG and RANKL Signal Transduction in Osteoblast Regulation Post Application Extract Collagen in Osteogenesis. Research Journal of Pharmacy and Technology. 2022; 15(6):2645-9. doi: 10.52711/0974-360X.2022.00442

Shafira Kurnia, Chiquita Prahasanti, Onge Victoria Hendro, Yokthan Ofier Siki, Wibi Riawan, Lambang Bargowo. OPG and RANKL Signal Transduction in Osteoblast Regulation Post Application Extract Collagen in Osteogenesis. Research Journal of Pharmacy and Technology. 2022; 15(6):2645-9. doi: 10.52711/0974-360X.2022.00442   Available on:

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