K. Naveen Kumar, Sreelaxmi Abbireddy, M. Chinna Eshwaraiah
K. Naveen Kumar1*, Sreelaxmi Abbireddy1, M. Chinna Eshwaraiah2
1Department of Pharmaceutical Chemistry, Anurag Pharmacy College, Kodad, Suryapet, Telangana, India – 508206.
2Department of Pharmacognosy, Anurag Pharmacy College, Kodad, Suryapet, Telangana, India – 508206.
Volume - 15,
Issue - 6,
Year - 2022
Abrus precatorius a successor member of Fabaceae family commonly known as Rosemary pea or Jacqueline. The thorough literature survey reveals that A. precatorious is found to have many pharmacological activities like Anti-bacterial, Anti-fungal, Anti-tumor, Analgesic, Anti-inflammatory, Antispasmodic, Anti-diabetic, Anti-serotonergic, Anti-migraine. Traditionally A. precatorius is used as one of the Principle anti diabetic plants in the multi-component herbal recipes. And the Anti- Diabetic activity of A. precatorious is yet to be explored in a more-wide view, in spite of the extensive work reported. In continuation of such investigations the shade dried leaf and seed extracts of A. precatorious were subjected to successive solvent extraction using Soxhlation using Benzene and Chloroform. Varying concentrations of the extracts were pre-incubated each with a-glucosidase and a-amylase followed by the addition of p-nitrophenyl glucopyranoside. The Benzene extract has shown highest anti-diabetic activity with a % inhibition in the range of 65.28 - 73.88 comparable with standard values. All the plant extracts were tested for phytochemical screening and anti-diabetic activity by inhibition of a-glucosidase enzyme, all the plant extracts were evaluated for anti-diabetic activity, the results of the extracts has been compared with the standard Voglibose. Leaf extract showed a positive result which is rich in chemotherapeutic constituents that could be potentially useful for the development of hypoglycemic drugs in the near future.
Cite this article:
K. Naveen Kumar, Sreelaxmi Abbireddy, M. Chinna Eshwaraiah. Phytochemical Screening and Pharmacological Evaluation of Anti Diabetic Activity of Abrus precatorius Plant Extracts. Research Journal of Pharmacy and Technology. 2022; 15(6):2688-0. doi: 10.52711/0974-360X.2022.00449
K. Naveen Kumar, Sreelaxmi Abbireddy, M. Chinna Eshwaraiah. Phytochemical Screening and Pharmacological Evaluation of Anti Diabetic Activity of Abrus precatorius Plant Extracts. Research Journal of Pharmacy and Technology. 2022; 15(6):2688-0. doi: 10.52711/0974-360X.2022.00449 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-6-53
1. Keerthana G, Kalaivani MK, Sumathy A: In-vitro alpha amylase inhibitory and antioxidant activities of ethanolic leaf extract of Croton bonplandianum. Asian J Pharm Res, 2013;6(4):32-36.
2. Narendra Garaniya, Atul Bapodra : Ethnobotanical and Phytopharmacology potenial of Abrus precatorius (L) A Review. Asian Pac J Trop Biomedicine, 2014, May 4(Suppl) S27-S34.
3. Anamika Das, Vernika Jain, Amarnath Mishra: A brief Review on a traditional herb Abrus precatorius (L). IP International Journal of Forensic Medicine and Toxicological sciences, Vol-I, Issue-I.
4. Monago C.C, Alumanah EO: Antidiabetic effect of Chloroform-Methanol extract of Abrus Precatorius Linn seed in Alloxan Diabetic Rabbit. J. Appl. Sci. Environment. Mgt 2005, Vol.9(1), 85-88.
5. Wakawa Henry Yusufu, Oluwayemisi Tanimowa, Sa adatu Aliyu Abubakar and Fasihuddin Badruddin Ahmed: Effects of Aqueous extracts of leaves of Abrus precatorius (Linn) on some Biochemical parameters in normal and alloxan induced Diabetic Rats. Asian journal of Biochemistry, 2017, vol-12, 44-48.
6. Ojo Joseph Sunday, Shola Kola Babatunde, Adeyinka Elizabeth Ajiboye, Racheal Majekodunmi Adedayo, Mufutau Adeyemi Ajao, Busayo Isreal Ajuwon: Evaluation of Phytochemical properties and invitro Antibacterial activity of the aqueous extracts of leaf, seed, and root of Abrus precatorius against Salmonella and Shigella. Asian Pacific Journal of Tropical Biomedicine, September 2016, Vol-6, Issue-9.
7. Anindita Banerjee, Bithin Maji, Sandip Mukherjee, Kausik Chaudhuri, Tapan Seal: Invitro Antidiabetic and Antioxidant activity of Methanol Extract of Tinospora Sinensis. Journal of Applied Biology and Biotechnology, Vol-5(03), pp 61-67, May-June 2017.