Author(s): Aashish Kumar, Ravinder Verma, Kunwar Pal, Deepika Purohit, Parijat Pandey, Vineet Mittal, Deepak Kaushik


DOI: 10.52711/0974-360X.2022.00547   

Address: Aashish Kumar1, Ravinder Verma2, Kunwar Pal3, Deepika Purohit3, Parijat Pandey4, Vineet Mittal1, Deepak Kaushik1*
1Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak – 124001, Haryana, India.
2Department of Pharmacy, School of Medical and Allied Sciences (SoMAS), G. D. Goenka University, Sohna Road, Gurugram – 122103.
3Department of Pharmaceutical Sciences, Indira Gandhi University, Meerpur, Rewari, Haryana - 123401, India.
4Department of Pharmaceutical Sciences, Gurugram University, Gurugram – 122018, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 7,     Year - 2022

Topical route of drug administration is more effective therapy for improving patient compliance and bioavailability. The topical administration of analgesics allows effective and painless deliverance of medicament with least side-effects. This investigation was aimed to develop and evaluate Diclofenac emulgel for topical drug delivery with enhanced anti-inflammatory and analgesic potential. Diclofenac is used as a first-line drug for acute and chronic pain and inflammation from a variety of causes. When applied topically the advantage of the drug is the avoidance of the first-pass metabolism, better patient compliance and site-specific for their action. Emulgel was prepared by using HPMC K4M as a gelling agent, light liquid paraffin as the oil base, Kollicream 3C and Kolliphor CS20 as emulsifiers via the QbD method. The emulgel formulation of diclofenac was optimized by central composite design and determines the effect of excipients on in vitro release. Emulgel formulation was evaluated for pH, drug content, viscosity, in vitro drug release and stability study. Optimized formulation showed pH, drug content and viscosity in an acceptable range. Based on the results of this investigation, it was summarized that diclofenac emulgel has a promising potential as an alternative to the conventional marketed dosage form.

Cite this article:
Aashish Kumar, Ravinder Verma, Kunwar Pal, Deepika Purohit, Parijat Pandey, Vineet Mittal, Deepak Kaushik. Quality by design approach for developing Emulgel of Diclofenac with central composite Design and Evaluation using in vitro release testing. Research Journal of Pharmacy and Technology. 2022; 15(7):3260-6. doi: 10.52711/0974-360X.2022.00547

Aashish Kumar, Ravinder Verma, Kunwar Pal, Deepika Purohit, Parijat Pandey, Vineet Mittal, Deepak Kaushik. Quality by design approach for developing Emulgel of Diclofenac with central composite Design and Evaluation using in vitro release testing. Research Journal of Pharmacy and Technology. 2022; 15(7):3260-6. doi: 10.52711/0974-360X.2022.00547   Available on:

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