Author(s): Roaa Hatem Al Gburi, Raid D. Hashim, Hayder Ahmed Kadhim, Şevki Adam, Haider Abdulkareem Almashhadani

Email(s): ,

DOI: 10.52711/0974-360X.2022.00580   

Address: Roaa Hatem Al Gburi1, Raid D. Hashim2, Hayder Ahmed Kadhim3, Şevki Adam4, Haider Abdulkareem Almashhadani5,6
1Department of Health in Baghdad Rusafa, Kamal Al-Samarrai Hospital, Baghdad, Iraq.
2Department of Pharmacy, Al-Rasheed University College, Baghdad, Iraq.
3Medical Laboratory Techniques Department, Al-Rasheed University College, Baghdad, Iraq.
4Department of Chemistry, Faculty of Science, Cankiri Karatekin University, 18100 Cankiri, Turkey.
5Department of Dentistry, Al-Rasheed University College, Baghdad, Iraq.
6College of Technical Engineering, The Islamic University, Najaf, Iraq.
*Corresponding Author

Published In:   Volume - 15,      Issue - 8,     Year - 2022

The Growth Differentiation Factor -15 (GDF-15) is a member of the transforming growth factor ß superfamily. It represents an example of the stress response cytokines. It's mostly found in cardiac myocytes, adipocytes, macrophages, endothelial cells, and vascular endothelial cells, whether they're generated normally or not. GDF-15 levels have increased and are associated with cardiovascular risk. Aim of the study: To investigate the correlation between angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) with the level of plasma GDF-15 in a group of hypertensive patients. Materials and methods: A case-control study involved 90 individuals, 60 hypertensive patients (36 on ACE inhibitors and 24 on ARBs) and 30 healthy individuals. Serum GDF-15 was measured and compared statistically between the two groups. Results: serum GDF-15 was significantly higher in both groups of hypertensive patients compared to the control group. In addition, there was no significant difference in mean serum GDF-15 concentration between patients treated with ACE inhibitors with those treated with angiotensin II receptor blockers. Conclusion: GDF-15 increases in hypertensive patients and might be a reasonable marker of cardiovascular disease. Both ACE inhibitors and ARBs are not powerful enough to decrease GDF-15 concentration to that of the control group.

Cite this article:
Roaa Hatem Al Gburi, Raid D. Hashim, Hayder Ahmed Kadhim, Şevki Adam, Haider Abdulkareem Almashhadani. Correlation of Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with serum GDF-15 in a group of hypertensive Iraqi patients. Research Journal of Pharmacy and Technology. 2022; 15(8):3466-0. doi: 10.52711/0974-360X.2022.00580

Roaa Hatem Al Gburi, Raid D. Hashim, Hayder Ahmed Kadhim, Şevki Adam, Haider Abdulkareem Almashhadani. Correlation of Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with serum GDF-15 in a group of hypertensive Iraqi patients. Research Journal of Pharmacy and Technology. 2022; 15(8):3466-0. doi: 10.52711/0974-360X.2022.00580   Available on:

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