Prabhulingayya S. Bhixavatimath, Akram Naikawadi, Yasmeen A. Maniyar, Mallappa Shalavadi, Gurudatta Maher, Vijayakumar Daroj
Prabhulingayya S. Bhixavatimath1*, Akram Naikawadi2, Yasmeen A. Maniyar3, Mallappa Shalavadi4, Gurudatta Maher1, Vijayakumar Daroj5
1Research Scholar, Dept of Pharmacology, BLDE (Deemed To Be) University, Vijayapura, Karnataka.
2Prof and Head, Dept of Pharmacology, Shri B. M. Patil Medical College, BLDE (Deemed To Be) University Vijayapur - 586103 Karnataka.
3Prof and Head, Dept of Pharmacology, S. N. Medical College and HSK Hospital and Research Center,
Bagalkot - 587102 Karnataka.
4Assist Prof, Dept of Pharmacology, HSK College of Pharmacy, Bagalkot - 587101, Karnataka.
5Prof and Principal, Cauvery College of Pharmacy, Devegouda Circle, Mysore - 570028, Karnataka.
Volume - 15,
Issue - 9,
Year - 2022
Background: The study of free radicals nowadays have become more attention as these are evoked continuously due to hazardous environmental conditions and food habits. Endogenously free radicals are introduced in our body due to exposure to different physiochemical conditions or some pathological states by various mechanisms. Oxidative stress occurs due to exposure of excess free radicals to body. Antioxidants act as a major defence against the free radical-mediated injury by scavenging them. Majority of the flavonoids found in plant products are known as antioxidants as they selectively scavenge the free radicals. Methods: Synthetic flavones (VMF41, VMF 43, VMF 45 and VMF 46) having different side chains on the: 3-hydroxy-2- (5-methyl, 7-methyl, 6-methyl, and 7--methoxy) 2- thiophen-4H-chromen-4-one structure were examined for free radical scavenging potential over nitric oxide, hydroxyl, and superoxide anion radicals by using appropriate in-vitro assay methods. Results and Discussion: Overall, with few exceptions, all the synthetic flavonoids (SFs) exhibited moderate free radical scavenging activity as compared to the standard drug. The test samples in the study showed dose dependant activity of scavenging activity. In nitric oxide radial scavenging activity, test flavonoids VMF 45 and VMF 46 exhibited significant scavenging activity at 50- 100µg/ml concentrations. The SFs VMF 43 and VMF 46 showed a good scavenging activity for hydroxyl, nitric oxide radicals and compounds VMF41, and VMF 43 showed significant scavenging activity at 50 µg/ml to 100µg/ml concentrations for superoxide radicals. However all the SFs at 10µg/ml concentration showed the low or poor radical scavenging activity. Conclusion: It is clear that these synthetic flavonoids (SFs) can be considered as potential antioxidant agents, however needs to be further tested at in vivo experiment to consider them as a lead antioxidant drug candidates.
Cite this article:
Prabhulingayya S. Bhixavatimath, Akram Naikawadi, Yasmeen A. Maniyar, Mallappa Shalavadi, Gurudatta Maher, Vijayakumar Daroj. An In vitro Evaluation of Potential Free Radical Scavenging Antioxidant activity of selected Novel Synthetic Flavones. Research Journal of Pharmacy and Technology. 2022; 15(9):3947-1. doi: 10.52711/0974-360X.2022.00661
Prabhulingayya S. Bhixavatimath, Akram Naikawadi, Yasmeen A. Maniyar, Mallappa Shalavadi, Gurudatta Maher, Vijayakumar Daroj. An In vitro Evaluation of Potential Free Radical Scavenging Antioxidant activity of selected Novel Synthetic Flavones. Research Journal of Pharmacy and Technology. 2022; 15(9):3947-1. doi: 10.52711/0974-360X.2022.00661 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-9-21
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