Author(s):
Christofori M.R.R. Nastiti, Rini Dwiastuti, Florentinus D.O. Riswanto
Email(s):
dikaocta@usd.ac.id
DOI:
10.52711/0974-360X.2023.00070 
Address:
Christofori M.R.R. Nastiti1, Rini Dwiastuti1, Florentinus D.O. Riswanto2*
1Division of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sanata Dharma, Yogyakarta 55282 Indonesia.
2Division of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Sanata Dharma, Yogyakarta 55282 Indonesia.
*Corresponding Author
Published In:
Volume - 16,
Issue - 1,
Year - 2023
ABSTRACT:
Resveratrol, a strong antioxidant and anti-inflammatory phytoalexin is potential to relieve impaired diabetic wound healing. Self-assembly nanoemulsions were developed to formulate good quality of resveratrol topical preparation. The surfactant system consisted of Kolliphor® RH 40 and Transcutol® were further optimized in terms of viscosity, pH and the percentage of transmittance. A central composite design combined with the response surface methodology successfully resulted in surface responses with the desirability value for viscosity, pH, and transmittance percentage were 0.99742, 0.60598, and 0.37137, respectively. These results contributed to the composite desirability of 0.6077. The optimal condition was obtained at a composition 5.70 g and 2.30 g of Kolliphor® RH 40 and Transcutol®, correspondingly.
Cite this article:
Christofori M.R.R. Nastiti, Rini Dwiastuti, Florentinus D.O. Riswanto. Response Surface Methodology Assisted Surfactant Optimization on the Novel Resveratrol Self-assembly Nanoemulsions. Research Journal of Pharmacy and Technology 2023; 16(1):411-7. doi: 10.52711/0974-360X.2023.00070
Cite(Electronic):
Christofori M.R.R. Nastiti, Rini Dwiastuti, Florentinus D.O. Riswanto. Response Surface Methodology Assisted Surfactant Optimization on the Novel Resveratrol Self-assembly Nanoemulsions. Research Journal of Pharmacy and Technology 2023; 16(1):411-7. doi: 10.52711/0974-360X.2023.00070 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-1-70
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