Author(s):
Sura B. Sharafaldeen, Amoura M. Abou-El-Naga, Saad S. Al-Dujialy, Ahmed Badawy
Email(s):
surabadie113@gmail.com
DOI:
10.52711/0974-360X.2023.00775 
Address:
Sura B. Sharafaldeen1, Amoura M. Abou-El-Naga1, Saad S. Al-Dujialy2, Ahmed Badawy3
1Zoology Department, Mansoura University, Eygpt.
2High Institute for Infertility Diagnosis and ART, Al-Nahrain University, Iraq.
3College of Medicine, Mansoura University, Egypt.
*Corresponding Author
Published In:
Volume - 16,
Issue - 10,
Year - 2023
ABSTRACT:
Several hormones may interact with the implantation process by mobilizing several molecular modulators in a spatiotemporal manner. A total of 31 women were selected intentionally, then divided into (16) with polycystic ovarian syndrome and (15) healthy women with male factor, the blood serum samples were analyzed by real-time quantitativepolymerase chain reaction (RT- qPCR) for measurement of the fold of expression for Progesterone (P4) and Prostaglandin (PGE2) in the day of ova pick up (OPU) and after 14 days of embryo transfer (ET) in pregnant and non-pregnant women for PCOS and Non-PCOS groups. The results showed that there were no statically significant differences encountered between non-PCOS andPCOS groups in the expression of progesterone and prostaglandin genes (P 0.7296) and ( P 0.0530) respectively. Conclusion: 1- P4 and COX-2 expression in women PCOS is less common in healthy women than in menopausal women. 2- COX-2 is one of the indicators to consider in the case of blastocyst adhesion to the uterine wall.3-In both the PCOS and non-PCOS groups, there was a small increase in P4 and PGE2 expression on the day of ova collection and after 14 days after embryo transfer.
Cite this article:
Sura B. Sharafaldeen, Amoura M. Abou-El-Naga, Saad S. Al-Dujialy, Ahmed Badawy. Research Journal of Pharmacy and Technology 2023; 16(10):4781-5. doi: 10.52711/0974-360X.2023.00775
Cite(Electronic):
Sura B. Sharafaldeen, Amoura M. Abou-El-Naga, Saad S. Al-Dujialy, Ahmed Badawy. Research Journal of Pharmacy and Technology 2023; 16(10):4781-5. doi: 10.52711/0974-360X.2023.00775 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-10-45
REFERENCES:
1. UsamaShoukath, UmamaShoukath, Salma Sultana, Mohammed NayeemUddin. Polycystic Ovary Syndrome (PCOS): A Thief of Womenhood. Asian J. Res. Pharm. Sci. 2018; 8(2):68-72.
2. Krushna K. Zambare, Avinash B. Thalkari, Nagesh S. Tour, Kavya V. Reddy. Herbal Remedies for treatment of Polycystic Ovary Syndrome. Asian J. Pharm. Tech. 2019; 9(2):112-114.
3. AkshayGade, RutujaSawant, ShreyaParkar, PrajaktaKegade. Polycystic ovary syndrome: An Overview, Diagnosis and Treatment of PCOS. Asian J. Pharm. Tech. 2020; 10(4):265-272.
4. Dhanalakshmi, S., Dhivya,C. A Perspective Studies on Herbalism for the Preventive of PCOS. Research J. Pharm. and Tech. 2018; 11(12): 5417-5424.
5. VeenaKirthika S, Jibi Paul, SenthilSelvam. P, SathyaPriya. V. Effect of Aerobic exercise and life style intervention among young women with Polycystic Ovary Syndrome. Research J. Pharm. and Tech. 2019; 12(9):4269-4273.
6. Anitharajendrababu, Mini Abraham. Effectiveness of Planned Teaching Programme regarding Polycystic Ovarian Disease among Adolescent Girls. Int. J. Adv. Nur. Management. 2017; 5(2):143-145.
7. NehaParmar, MunshiRuzdaKhanam, Patel Moshmi, PanchalShruti, Goyara Krishna, Christian Brinky, NinamaNidhi. A Study to assess The Effectiveness of Planned Teaching Programme on knowledge regarding Polycystic Ovarian Syndrome among Adolescent Girls in Selected Colleges at Nadiad City, Gujarat State. Int. J. of Advances in Nur. Management. 2019; 7(1):06-08.
8. KhushbooBrar,TarundeepKaur, P. VadivukarrasiRamanadin. Knowledge regarding Poly Cystic Ovarian Syndrome (PCOS) among the Teenage Girls. Int. J. Nur. Edu. and Research. 2016; 4(2):136-140.
9. Asha K Varughese, VeenaGreettaTauro. Effectiveness of Structured Teaching Programme (STP) on Knowledge regarding Polycystic Ovarian Syndrome (PCOS) among Adolescent Girls, Kollam. Int. J. Nur. Edu. and Research. 2018; 6(4):360-362.
10. S. Tamilselvi, S. J Nalini, R. Vijayaraghavan. Effectiveness of Self Help Strategies {SHS} for PCOS among Young Adult Girls at Selected Colleges at Chennai- Pilot study report. Research J. Pharm. and Tech. 2018; 11(7):3145-3148.
11. Huang, Y. et al. Altered amphiregulin expression induced by diverse luteinizing hormone receptor reactivity in granulosa cells affects IVF outcomes. Reproductive Biomedicine Online. 2015; 30: 593–601, doi: 10.1016/j.rbmo. 2015; 03.001
12. Allen VM, Wilson RD, Cheung A.Pregnancy outcomes after assisted reproductive technology. J Obst Gynaecol Can. 2006; 28(3): 220-250
13. Conneely OM, Mulac-Jericevic B, DeMayo F, Lydon JP, O’Malley BW. Reproductive functions of progesterone receptors. Recent Prog Horm Res. 2002; 57:339–355.
14. Conneely OM, Mulac-Jericevic B, Lydon JP. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids. 2003; 68: 771–778.
15. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 1990; 9: 1603–1614.
16. Mulac-Jericevic B, Conneely OM. Reproductive tissue selective actions of progesterone receptors. Reproduction. 2004; 128: 139–146.
17. Mote PA, Balleine RL, McGowan EM, Clarke CL. Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma. Hum Reprod. 2000; 15(Suppl 3): 48–56.
18. Mote PA, Johnston JF, Manninen T, Tuohimaa P, Clarke CL. Detection of progesterone receptor forms A and B by immunohistochemical analysis. J ClinPathol. 2001; 54: 624–630.
19. Vallejo G, Ballare C, Baranao JL, Beato M, Saragueta P. Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells. Mol Endocrinol. 2005; 19: 3023–3037.
20. Mangal RK, Wiehle RD, Poindexter AN 3rd, Weigel NL. Differential expression of uterine progesterone receptor forms A and B during the menstrual cycle. J Steroid Biochem Mol Biol. 2004; 63:195–202.
21. Yu N, Yan W, Wang Y, Yin T, Guo Y, Yang J. Effect of Zhuyun recipe on endometrial pinopode expression in mice with embryonic implantation dysfunction and ovulation stimulation. Exp Ther Med. 2015; 9:488–92
22. Olsson A, Dimberg A, Kreuger J, Welsh L. VEGF receptor signalling in control of vascular function. Nat Rev. 2006; 7: 359–71.
23. Kala M. Role of stress and stress hormones on ovulation and implantation in mice involvement of adrenals. 2017; Shodhganga: http:// hdl.handle.net/10603/188038.
24. Piltonen T, Chen J, Khatun M, Kangasniemi M, Liakka A, Spitzer T, Tran N, Huddlestone H, Irwin JC, Giudice LC. Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro. Hum Reprod. 2015; 30(5):1203–15.