Author(s):
Dalpreet Singh, Ramandeep Kaur, Suman Lata
Email(s):
sumanlata.2722005@gmail.mail.com
DOI:
10.52711/0974-360X.2023.00806 
Address:
Dalpreet Singh, Ramandeep Kaur, Suman Lata*
Department of Pharmaceutical Chemistry, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, BELA, ROPAR, 140111, I. K. G. Punjab Technical University, Kapurthala, Jalandhar, Punjab, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 10,
Year - 2023
ABSTRACT:
The most important five-membered hetrocyclic molecules with a wide range of biological action are thiazoles. Sulphur atoms are found at position 1 while nitrogen atoms are found at position 3. The goal of this research is to compile a list of activities and innovative methodologies for the synthesis of thiazole derivatives. The entire review discusses thiazole's numerous properties, including antibiotics, antimalarials, antidiabetics, anticancer, anti-inflammatory, diuretics, antimycobactreial, and methods for thiazole synthesis.
Cite this article:
Dalpreet Singh, Ramandeep Kaur, Suman Lata. Thiazole Ring: A Pharmacological Active Scaffold. Research Journal of Pharmacy and Technology 2023; 16(10):4981-6. doi: 10.52711/0974-360X.2023.00806
Cite(Electronic):
Dalpreet Singh, Ramandeep Kaur, Suman Lata. Thiazole Ring: A Pharmacological Active Scaffold. Research Journal of Pharmacy and Technology 2023; 16(10):4981-6. doi: 10.52711/0974-360X.2023.00806 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-10-76
REFERENCES:
1. Joule AJ. Mills K. Heterocyclic chemistry. John Wiley and Sons. 2010; 25(5): 461.
2. Mukhtyar. S. Saini, A. Kumar, J. Dwivedi, R. Singh. A Review: Biological significances of heterocyclic compounds Int J Pharm Sci Rev Res. 2013; 4(3): 66-77.
3. Gupta V. Kant V. A review on biological activity of imidazole and thiazole moieties and their derivatives. SciInt.2013;1(7): 253-260.
4. Kouhkan M. Souldozi A. Talebi R. In vitro antimicrobial activity of new substituted phenylthiazole derivatives. Iranian J Toxicol. 2018; 12(1): 33-37.
5. Kumar P. Study of synthesis and biological importance of thiazole (heterocyclic compound). Orient J Chemistry. 2013; 29(3): 1225-1231.
6. Das D. Sikdar P. Bairagi M. Recent developments of 2-aminothiazoles in medicinal chemistry. Eur J Med Chem. 2016; 109: 89-98.
7. Singh N. Sharma US. Sutar N. Kumar S. Sharma UK. Synthesis and antimicrobial activity of some novel 2-amino thiazole derivatives. J Chem Pharm Res. 2010; 2(3): 691-698.
8. Alsryfy A.H. Mosaa Z.A. Alrazzak N. Synthesis and characterization of new schiff base derived from 1,2-Di (indol-2-yl)-2-hydroxyethanon. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2015; 6(2): 798-802.
9. Behzad G. Hamid B. Hadi H. Study of Antibacterial Effect of Novel Thiazole, Imidazole, and Tetrahydropyrimidine Derivatives against Listeria Monocytogenes. AMHSR.2015;13: 103-107.
10. Al-Shamkhani ZAN. Al-Hazam HA. Microwave assisted synthesis, characterizations and antibacterial activity of some of thiazole derivatives. Res J Pharm Biol Chem Sci. 2015; 6(2): 718-725.
11. Böttcher, C. Chapman A. Fellermeier F. Choudhary M. Scheel D. Glawischnig E. The biosynthetic pathway of indole-3-carbaldehyde and indole-3carboxylicacid derivatives in Arabidopsis. Plant Physiol. 2014; 165: 841–853.
12. Vrushali N. Patil, Ameya G.Yadav, A.S.Bobade S.V.Athlekar, L.SPatil, Abhay Chowdhary. Synthesis and Evaluation of New Benzothiazole Derivatives as Potential Antimicrobial Agents. Research J. Pharm. and Tech. 2010; 3 (4): 1044-1046.
13. Derek J.M. Thiazoles and Thiazolidinones as COX/LOX Inhibitors. Molecules. 2018; 33(3): 685.DOI. 10.3390/molecules23030685.
14. Darji, N. D.; Pasha, T.Y.; Bhandri, A.; Molvi, K. I.; Desai, S. A.; Makwana, M. V. Synthesis of some novel 2, 4, 5-trisubstituted thiazoles as possible antifungal agents. J. Pharm. Res. 2011; 4: 4465-4466.
15. Nour E.A. Abdel-Sattar. Abeer M. El-Naggar M.S. Abdel-Mottaleb. Novel Thiazoles Derivatives of Medicinal Potential : Synthesis and Modeling J. Chem. 2017; 410. DOI.org/10.1155/2017/4102796.
16. Alrazzak N.A. Synthesis, characterization and study some of physical properties of novel 1,3,4-oxadiazole derivatives IOP Conference Series. Materials Science and Engineering. 2018; 454(1), art.no.012096.
17. Rodislav V.K. Vladimir P. Isothiazoles (1,2Thiazoles): Synthesis, Properties and Applications. Russian Chem. Rev. 2002; 71(8): 673-694.
18. Sammes P.G. Comprehensive Organic Chemistry. Vol. 4, Heterocyclic Compounds. 1979; 20(1): 976;
19. Shelly P. Ravindra K.R. Green synthetic strategies toward thiazoles: a sustainable approach. Chem. of Heterocyclic Compounds. 2020; 56: 445–454. DOI:10.1016/S0223-5234(99)00215-9.
20. Kumaraswamy Gullapelli, Ravichandar Maroju, Ramchander Merugu. Synthesis, In-vitro and In-silico Anti-inflammatory activity of new Thiazole derivatives. Research Journal of Pharmacy and Technology. 2021; 14(8): 4253-0. doi: 10.52711/0974-360X.2021.00738
21. Niraimathi V, Jerad Suresh A, Kokil A.R. Evaluation of (In-Vitro) Anti-Inflammatory Activity of Azomethines of Aryl Thiazoles. Research J. Pharm. and Tech. 2011; 4(6):942-943.
22. Kumaraswamy Gullapelli, Ravichandar Maroju, Ramchander Merugu. Synthesis, In-vitro and In-silico Anti-inflammatory activity of new Thiazole derivatives. Research Journal of Pharmacy and Technology. 2021; 14(8): 4253-0. doi: 10.52711/0974-360X.2021.00738
23. Reddy G.M. Garcia J.R. Reddy V.H. Andrade A.M. Camilo A. Ribeiro R.A. Lazaro S.R. Synthesis, antimicrobial activity and advances in structure-activity relationships (SARs) of novel trisubstituted thiazole derivatives. Eur. J. Med. Chem. 2016; 123: 508–513. DOI.10.1016/j.ejmech.2016.07.062
24. Robinson, R. A new synthesis of oxazole derivatives. J. Chem. Soc.1909; 95: 2167– 2174. DOI.10.1039/ct9099502167.
25. D. S. Bele, I. Singhvi. Synthesis and Analgesic Activity of Some Mannich Bases of 6-Substituted-2-Aminobenzothiazole.. Research J. Pharm. and Tech. 2008; 1(1):22-24.
26. Khalifa M.E. Recent developments and biological activities of 2-aminothiazole derivatives. Journal of The Slovenian Chemical. 2018; 65: 1-22
27. Bele D.S. Singhvi I. Synthesis of Some Mannich Bases of 6-Substituted-2-Aminobenzothiazole as Analgesic. Research J. Pharm. and Tech. 2014;7(3):316-321.
28. Suresh Kumar, Renu Saharan, Randhir Singh. Synthesis, Characterization and Biological Evaluation of some Novel 2-Substituted Aminothiazoles. Research Journal of Pharmacy and Technology. 2021; 14(6): 3104-0. doi: 10.52711/0974-360X.2021.00542
29. Varsha A D, Rohini R P. Synthesis of some Sulphur and Nitrogen containing Heterocyclic Compounds. Asian J. Pharm. Res. 2017; 7(1): 21-24.