Author(s): Tasneem Khandekar, Nirmal Kumar Pradhan

Email(s): tkhandekar144@gmail.com , pradhan.nirmal12@gmail.com

DOI: 10.52711/0974-360X.2023.00809   

Address: Tasneem Khandekar1, Nirmal Kumar Pradhan2
1Dept. of Physiology, Hooghly Mohsin College, The University of Burdwan, Chinsurah, Hooghly, 712101, West Bengal, India.
2Dept. of Physiology, Hooghly Mohsin College, The University of Burdwan, Chinsurah, Hooghly, 712101, West Bengal, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 11,     Year - 2023


ABSTRACT:
In diabetic rats, the hypoglycemic potential of an aqueous extract of Jussiaea repens (50mg/100gm body weight) was examined. The herbal extract's impact on a number of hematological indicators was also studied. Eighteen albino rats, each contain 6 rats, were placed into three groups: vehicle control, diabetes control, and supplemented group. To develop diabetes, a single i.p injection of STZ (80mg/kg body weight) was given. Hematological markers include hemoglobin (Hb), red blood cell (RBC) count, white blood cell (WBC) count, packed cell volume (PCV), lymphocytes, and neutrophils, as well as blood glucose levels and HbA1c were assessed. STZ-induced diabetic rats fed the extract had lower fasting blood glucose levels, which was statistically significant (p<0.05). The HbA1c level in the diabetic control group increased drastically, but the level in the extract-treated supplemented group reduced significantly. Hb, PCV, RBC, and WBC as well as their differentials, were significantly reduced in diabetic control rats, whereas the supplemented group recovered significantly.. These findings imply that the aqueous extract of Jussiaea repens has hypoglycemic action and overcomes the abnormalities in STZ-induced diabetic rats' blood parameters.


Cite this article:
Tasneem Khandekar, Nirmal Kumar Pradhan. The impact of Jussiaea repens aqueous extract on Hyperglycemic and Hematological markers in Diabetic male rat induced by Streptozotocin. Research Journal of Pharmacy and Technology 2023; 16(11):4999-4. doi: 10.52711/0974-360X.2023.00809

Cite(Electronic):
Tasneem Khandekar, Nirmal Kumar Pradhan. The impact of Jussiaea repens aqueous extract on Hyperglycemic and Hematological markers in Diabetic male rat induced by Streptozotocin. Research Journal of Pharmacy and Technology 2023; 16(11):4999-4. doi: 10.52711/0974-360X.2023.00809   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-11-3


REFERENCES:
1.    Lolok N, Mashar HM, Annah I, Ahmed S, Yuliastri WO, Muhammad I. Antidiabetic effect of the combination of garlic peel extract (Allium sativum) and onion peel (Allium cepa) in rats with oral glucose tolerance method. Research J. Pharm. and Tech. 2019; 12(5): 2153-2156. Doi:10.5958/0974-360X.2019.00357.3
2.    Kushwaha SP, Rawat SK, Kumar P, Abhishek, Tripathi K. Coupling antioxidant and antidiabetic assets of 2,4-thiazolidinedione derivatives. Asian J. Pharm. Ana. 2011; 1(4): 71-73.
3.    Salim B. Diabetes mellitus and its treatment: a review. International Journal of Diabetes and Metabolism. 2005; 13: 111-134.
4.    Oyedemi SO, Adewusi EA, Aiyegoro OA, Akinpelu, DA. Antidiabetic and Haematological Effect of Aqueous Extract of Stem Bark of Afzelia africana (Smith) on Streptozotocin-Induced Diabetic Wistar Rats. Asian Pac.J.Trop. Biomed. 2011; 1(5): 353-58.
5.    Ponnanikajamideen M, Rajeshkumar S, Annadurai G. In vivo antidiabetic and in vitro antioxidant and antimicrobial activity of aqueous leaves extract of Chamaecostus cuspidatus. Research J. Pharm. And Tech. 2016; 9(8): 1204-1210. Doi: 10.5958/0974-360X.2016.00230.4
6.    Sandokar SD, Sahare AY, Bodhankar SS, Akare SC, Wanjari AD. Formulation and evaluation of herbal ointment of Angeissus latifolia bark extract. Res. J. Pharma. Dosage Forms and Tech. 2019; 11(3): 149-151. Doi:10.5958/0975-4377.2019.00025.9
7.    Pandeya SN, Kumar R, Kumar A, Pathak AK. Antidiabetics review on natural products. Research J. Pharm. and Tech. 2010; 3(2): 300-318.
8.    Saifi A, Chauhan R, Dwivedi J. Development of a polyherbal formulation FMST and evaluation for antidiabetic activity in alloxan induced diabetic rats. Asian J. Pharm. Res. 2017; 7(1): 1-7. Doi: 10.5958/2231-5691.2017.00001.6
9.    Chouhan R, Patel C, Panigrahi J. Greener approach for copper nanoparticles synthesis from Catharanthus roseus and Azadirachta indica leaf extract and their antibacterial and antioxidant activities. Asian J. Res. Pharm. Sci. 2018; 8(2): 81-90. Doi: 10.5958/2231-5659.2018.00016.4
10.    Jadhav ST, Gaikwad NA, Mane IV, Kengar MD, Pujari AS, Devkar SB. Formulation and evaluation of ointment and liniment using Moringa oleifera seed extract. Research Journal of Pharmacognosy and Phytochemistry. 2019; 11(2): 45-48.
11.    Naskar K. Medicinal Plants of Indian Sundarban. Pub. RKM Narendrapur, Kolkata; 2007
12.    Dassanayake DM. A revised hand book to the flora of Ceylon Vol IV. Amerind Pub. Co. New Delhi. 1983; 341.
13.    Sunyapridakul L, Sae CT, Kitti R , Sakchai P. Chinese Medicinal Plants in northern Thailand. Chiang Mai Medical Bulletin. 1983; 137-157.
14.    Roy T, Paul S, Chowdhury VR, Das A et al. Antihyperglycemic activity of Ficus carica leaves extracts on streptozotocin induced diabetic rats. Research J. Pharm and Tech. 2021; 14(8): 4151-6. Doi: 10.52711/0974-360X.2021.00718
15.    Mathur JN. National Centre for Laboratory Animal Sciences (NCLAS) – A profile, The Indian Council of Medical Research. ICMR Bulletin. 2004; 34(4):21-28.
16.    Nayak SS, Pattabiraman TN. A new colorimetric method for the estimation of glycosylated haemoglobin. Clin Chim Acta. 1981; 109:267-74.
17.    Cheesbrough, M. District Laboratory Practice in Tropical Countries part 2. Cambridge University Press. 2004; pp 249-258.
18.    Muhammad NO, Adeyina AO,  Peters OM. Nutritional evaluation of fungi trerated cocoa bean shell. Nigerian J. Pure Appl. Sci. 2000; 5: 1059-64.
19.    Ashafa OT, Yakubu MT, Grierson DS, Afolayan AJ. Toxicological evaluation of the aqueous extract of Felicia muricata Thunb. leaves in Wistar rats. African Journal of Biotechnology. 2009; 8:949-54.
20.    Muhammad NO, Oloyede OB. Haematological parameters of broiler chicks fed Aspergillus niger-fermented Terminalia catappa seed meal-based diet. Global J.Biotechnol Biochem. 2009; 4: 179 – 183.
21.    Yakubu MT, Akanji MA,Oladiji AT. Haematological evaluation in male albino rats following chronic consumption of aqueous extract of Fadogia agrestis stem. Pharmacol Manag. 2007; 3:34 – 38.
22.    Mohammed RK, Ibrahim S, Atawodi SE, Eze ED, Suleiman JB. Anti-diabetic and Haematological Effects of n-butanol fraction of Alchornea cordifolia Leaf Extract in Streptozotocin-induced Diabetic Wistar Rats. Global Journal of Medicinal Plant Research. 2012; 1(1): 14-21.
23.    Qi LW, Liu EH, Chu C, Peng YB, Cai HX, Li P. Anti Diabetic  agents from natural products- an update from 2004-2009. Current Topics in Medicinal Chemistry. 2010; 10(4): 434-457.
24.    Khandekar T, Roy A, Pradhan N. Aqueous extract of Jussiaea repens L. ameliorates diabetes associated complications in STZ induced diabetic male rats. International Journal of Bio-pharma Research. 2020; 9(8): 2683-2690. http://doi.org/ 10.21746/ijbpr.2020.9.8.1.
25.    Consesus committee. Consensus statement on the the worldwide standardization of hemoglobin A1c measurement : the American Diabetes Association, European Association for the study of diabetes, International Federation of Clinical Chemistry and Laboratory Medicine, and the International Diabetes Federation. Diabetes Care. 2007; 30:2399-400.
26.    Pattabiraman K, Muthukumaran P. Antidiabetic and antioxidant activity of  Morinda tinctoria roxb fruits extract in streptozotocin induced diabetic rats. Asian J. Pharm. Tech. 2011; 1(2): 34-39
27.    Mohammed A, Adelaiye AB, Bakari AG, Mabrouk MA. Anti-diabetic and some haematological effects of ethylacetate and n-butanol fractions of Ganoderma lucidum aqueous extract in alloxan-induced diabetic wistar rats. Internationl Journal of Medicine and Medicinal Sciences. 2009; 1(12): 530-535.
28.    Baynes JW,Thorpe SR. Role of oxidative stress in diabetic complications: A new perspective on an old paradigm. Diabetes. 1999; 48: 1-9.
29.    Arun GS, Ramesh KG. Improvement of insulin sensitivity by perindopril in spontaneously hypertensive and streptozotocin diabetic rats. Indian Journal of Pharmacology. 2002; 34: 156-164.
30.    Ooh KF, Ong HC, Wong FC et al. High performance liquid chromatography profiling of health-promoting phytochemicals and evaluation of antioxidant, antilipoxygenase, iron chelating and anti-glucosidase activities of wetland macrophytes. Pharmacogn Mag. 2014; 10(3):S445-S445. http://doi.org/ 10.4103/0973-1296.139767.
31.    Ohlsson A, Aher SM. Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2014; 26(4):CD004863. doi: 10.1002/14651858.CD004863.pub4
32.    Oyedemi SO, Yakubu MT, Afolayan AJ. Effect of aqueous extract of Leonotis leonurus (L) R. Br leaves in male Wistar rats. Human Experimental Toxicology. 2010; 29: 377-384.
33.    Swenson MJ, Reece OW. Duke’s Physiology of Domestic Animals. Comstock Publishing Associates, Ithaca. 1993; pp: 312-315
34.    Adedapo AA, Adegbayibi AY, Emikpe BO. Some clinicopathological changes associated with the aqueous extract of the leaves of Phyllanthus amarus in rats. Phytotherapy Research. 2005; 19: 971-976.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available