Author(s):
Desi Prawita Sari, Jekson Martiar Siahaan, Hendrika Andriana, Reza Yuridian Purwoko, Binarwan Halim
Email(s):
jekson.siahaan.sked@gmail.com
DOI:
10.52711/0974-360X.2023.00934 
Address:
Desi Prawita Sari3, Jekson Martiar Siahaan1,2*, Hendrika Andriana4,5, Reza Yuridian Purwoko4, Binarwan Halim5
1Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia, Medan.
2Department of Molecular Biology, Master Program Biomedical Sciences, Faculty of Medicine, Universitas Methodist Indonesia, Medan.
3Student of Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Methodist Indonesia, Medan.
4Department of Histology, Faculty of Medicine, Universitas Methodist Indonesia, Medan.
5Department of Research Methodology, Master Program Biomedical Sciences, Faculty of Medicine, Universitas Methodist Indonesia, Medan.
*Corresponding Author
Published In:
Volume - 16,
Issue - 12,
Year - 2023
ABSTRACT:
Cisplatin is a potent chemotherapy drug that is associated with several side effects such as myelotoxicity, gastrointestinal toxicity, ototoxicity neurotoxicity, cardiotoxicity, and nephrotoxicity2-5. Cardiotoxic manifestations of cisplatin chemotherapy have been described: heart failure, angina, acute myocardial infarction, thromboembolic events, autonomic cardiovascular dysfunction, both hypertension and hypotension, myocarditis, pericarditis, and severe congestive cardiomyopathy. Oxidative stress that occurs when antioxidant defenses are inadequate can damage lipids, proteins, carbohydrates, and DNA. (Ocimum bacilicum) which belongs to the Lamiaceae family as a rich source of phytochemical compounds that can show countless pharmacological effects. This study aims to determine the cardioprotective activity of extract ethanol of Ociumum bacilicium on rats induced cisplatin. The result show that ethanol extract of Ocimum bacilicum has antioxidant activity. The cardioprotective activity of ethanol extract of Ocimum bacilicum by reducing the level of CK-MB and LDH as cardiac biomarker. Extract dose 300mg/kg BB reduce the level of CK-MB into 1200,427±15,924ng/mL meanwhile the level of LDH into 7,345±0,064 ng/mL. Briefly, it can be concluded that Ociumum bacilicium has cardioprotective effect.
Cite this article:
Desi Prawita Sari, Jekson Martiar Siahaan, Hendrika Andriana, Reza Yuridian Purwoko, Binarwan Halim. Cardioprotective effect of Extract Ethanol Ocimum basilicum on Rat Induced Cisplatin. Research Journal of Pharmacy and Technology. 2023; 16(12):5770-4. doi: 10.52711/0974-360X.2023.00934
Cite(Electronic):
Desi Prawita Sari, Jekson Martiar Siahaan, Hendrika Andriana, Reza Yuridian Purwoko, Binarwan Halim. Cardioprotective effect of Extract Ethanol Ocimum basilicum on Rat Induced Cisplatin. Research Journal of Pharmacy and Technology. 2023; 16(12):5770-4. doi: 10.52711/0974-360X.2023.00934 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-12-35
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